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WHO Declares MPOX a Global Health Threat. What’s Next?

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World Health Organization (WHO) he declared MPOX constitutes a public health emergency of international concern as a consequence of the increasing variety of cases within the Democratic Republic of the Congo and the potential risk of further spread of the disease.

This is now prompting a coordinated international response to a unprecedented event and resource mobilizationresembling vaccines and diagnostic tests to stop the spread of this infectious disease.

But the WHO has declared mpox a pandemic. Instead, the measures it has triggered are designed to forestall it from becoming a pandemic.

What caused the most recent alert?

Mpox, once generally known as monkeypox, is a viral infection closely related to smallpox. Initial symptoms include fever, headache, swollen lymph nodes, and muscle pain. Then a typical rash appears, mainly on the face, hands, and feet.

The spread of MPox in some African countries has prompted the African Centers for Disease Control and Prevention to declare Earlier this week, mpox declared a public health emergency for mainland security. It is the primary time the organization has issued such an alert since its founding in 2017.

The situation within the Democratic Republic of Congo, in Central Africa, has been particularly worrying for over a 12 months.

There are two types or clades of mpox. Clade II, which originated in West Africa, is less serious. It has a mortality rate of as much as 1% (in other words, about one in 100 persons are expected to die from it). But clade I, originating in Central Africa, has a mortality rate of as much as 10% (up to 1 in ten people die). This is comparable to 0.7% mortality rate for the Omicron variant of the SARS-CoV-2 virus that causes COVID. The Democratic Republic of the Congo is witnessing large outbreaks of the more deadly clade I mpox.

Mpox is endemic in parts of central and western Africa, where the virus occurs in animals and may spread to humans. Outbreaks They grewwith greater spread of disease from individual to individual since 2017

This is partly due to very low level of immunity to the mpox virus, which is said to the virus that causes smallpox. Mass vaccination against smallpox ceased worldwide greater than 40 years ago, leading to minimal population immunity to mpox.

The WHO designation announced this week refers to clade I. Not only does it have a higher mortality rate, but it surely also has recent mutations that increase human-to-human spread. These changes, and a global lack of immunity to mpox, are making the world’s population sensitive to the virus.

There are two different epidemics

In 2022, an outbreak of MPox swept through non-endemic countries, including outside Africa. It was a clade II variant originating in Nigeria, called clade IIb. It was sexually transmitted, affected mostly men who’ve sex with men, and had a low mortality rate.

The epidemic peaked in 2022 when vaccines were made available to at-risk people in high-income countries, but cases surged in 2024.

During the identical period, large clade I epidemics occurred within the Democratic Republic of the Congo, but they attracted much less attention.

There were no vaccines there, even in 2023when there have been 14,626 cases and 654 deaths. The mortality rate was 4.5% and was higher in children.

In fact, most cases and deaths occur within the Democratic Republic of Congo. we were childrenThis means that almost all of the transmissions are non-sexual in nature and are It is probable that it took place through close contact or respiratory aerosols.

The virus mutates, becoming more contagious.
Dotted Yeti/Shutterstock

However, in 2023 The outbreak within the non-endemic a part of the country, South Kivu within the east, was almost definitely sexually transmitted, suggesting a couple of epidemic and different modes of transmission within the Democratic Republic of the Congo.

By mid-2024 it was already more cases more within the country than in the entire of 2023 – over 15,600 cases and 537 deaths.

Testing capability within the Democratic Republic of the Congo is restricted, most cases will not be confirmed by laboratory testing, and the info we’ve got come from a small sample of genomic sequences from the Kamituga region in South Kivu.

The clade I virus has been shown to mutate around September 2023 into a variant termed clade Ib, which is more easily contagious between people. We haven’t got much data to match these viruses with the viruses causing cases in the remainder of the country.

Mpox is expanding internationally

Last month the virus It has spread to countries that share a border with the Democratic Republic of Congo – Rwanda and Burundi. It has also spread to other East African countries resembling Kenya and Uganda. Neither of those countries has previously reported cases of mpox.

In a connected, mobile world, cases can spread to other continents, similar to mpox did in 2018. from Nigeria to UK and other countries.

Several travel-related cases that occurred in 2018–2019 could have led to a widespread, multi-country clade IIb outbreak in 2022.

We have vaccines, but not where they’re needed

Because mpoxvirus and poxviruses are related (each are orthopoxviruses), variola vaccines offer protection against mpox. These vaccines were used to manage the 2022 clade IIb epidemic.

However, a lot of the world has never been vaccinated and has no immunity to MPox.

Newer vaccine (called Jynneos in some countries and Imvamune or Imvanex in others) is effective. However, supplies are limited and vaccines are scarce within the Democratic Republic of Congo.

WHO’s declaration of mpox as a public health emergency of international concern will help mobilize vaccines where they’re needed. The African Centers for Disease Control have already begun negotiations to secure 200,000 doses of vaccine, a fraction of what is required to manage the epidemic within the Democratic Republic of Congo.

A healthcare worker wearing blue gloves draws the MPox vaccine into a syringe.
There are vaccines against MPox, but most individuals have never been vaccinated.
Jeenah Moon/AP/AAP

What will occur now?

Ultimately, a serious outbreak anywhere on this planet is a concern for all of us because it will probably spread globally through travel, as happened with the COVID pandemic.

The best approach is source control, and the most recent WHO statement will help mobilise the needed resources.

Surveillance of the spread of this more serious version of mpox can also be essential, on condition that many countries lack widespread testing capability. We will due to this fact need to depend on “suspected cases,” based on a clinical definition, to trace the epidemic.

Open source software epidemiological interview – resembling using AI to watch trends in rashes and fevers – is also used as an early warning system in countries with weak health systems or delayed reporting of cases.

An additional complication is that 20-30% of individuals with mpox may concurrently have chickenpox, an unrelated infection that also causes a rash. So a preliminary diagnosis of chickenpox (which is less complicated to check for) doesn’t rule out mpox.

Effective communication and addressing resistance to public health measures and misinformation are also key. We saw how vital this was in the course of the COVID pandemic.

Now, WHO will coordinate the worldwide response to the pandemic, with a give attention to equity in disease prevention and access to diagnostics and vaccines. It is as much as individual countries to do what they’ll to follow the International Health Regulations and protocols on how one can manage such a global emergency.


This article was originally published on : theconversation.com
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Health and Wellness

US communities phase out fluoride use in public drinking water

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fluoride, water


There is a battle raging in American cities over whether to proceed using fluoride in water.

This is a process generally known as fluoridation that began around 1945. According to to the American Cancer Society became popular across the country after scientists noticed that individuals living in water with higher concentrations of fluoride had less tooth decay.

In 1962, the U.S. Public Health Service (PHS) advisable adding fluoride to public drinking water supplies to forestall tooth decay. The American Cancer Society estimates that fluoride is currently used in public drinking water supplied to roughly three in 4 Americans.

However, opponents have been warning for years that fluoride in drinking water is unsafe to devour. One of the organizations leading this initiative is Fluoride Action Network (FAN). The organization, whose mission is to lift awareness of what it claims is the “toxicity of fluoride compounds,” says many of the world’s developed countries don’t use fluoride in drinking water at the identical levels as America, or in any respect.

The organization says yes it helped over 500 communities successfully reject fluoridation, and there could also be more.

Federal leaders have gotten increasingly vocal in their support for ending the use of fluoride

While FAN says communities have rejected fluoridation for the past few a long time and the method has stalled in consequence, the fight has been thrust into the highlight over the past few months.

First, the National Toxicology Program, a federal agency throughout the Department of Health and Human Services, reported with “moderate certainty” that there may be an association between communities with higher levels of fluoride exposure and lower IQ in children. According to the Associated Press, these communities use greater than twice the advisable limit.

A month later, a federal judge apparently ordered the U.S. Environmental Protection Agency (EPA) to further regulate fluoride in drinking water because higher levels could affect children.

Robert F. Kennedy, nominated by President-elect Donald Trump to direct the Department of Health and Human Services, announced an end to fluoridation.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

WATCH: Cynthia Erivo on the importance of being a sister – Essence

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“; } }); // Drag and scroll functionality const playlistContainer = document.getElementById(‘playlist’); let isDown = false; let startY; let scrollTop; playlistContainer.addEventListener(‘mousedown’, (e) => { isDown = true; playlistContainer.classList.add(‘active’); playlistContainer.offsetTop; scrollTop = playlistContainer.scrollTop; }); playlistContainer.addEventListener(‘mouseleave’, () => { isDown = false; playlistContainer.classList.remove(‘active’); }); ‘, () => { isDown = false; playlistContainer.classList.remove(‘active’); playlistContainer.addEventListener(‘mousemove’, (e) => { if (!isDown) return; e.preventDefault(); const y = e.pageY -List Container playlist.offsetTop; const walk = (y – startY) * 3; // quick playlistContainer.scrollTop = scrollTop – walk; }); } } if (” !== ‘efoc24’) { // Check DoubleVerify Quality Targeting signals before rendering the player if ( ‘undefined’ !== PQ type ) { PQ.cmd.push(function () { // If DVQT signals are not available after 500 ms, render the player anyway. const timeout_id = setTimeout( jwPlayerRender, 500 ); // Get “Authentic Direct” signals. PQ.getTargeting({ signals: [‘abs’] }, function(error, targetingData) { clearTimeout(timeout_id); jwPlayerRender(error? undefined: targetingData); }); }); } else { jwPlayerRender(); } function jwPlayerRender( dvqt_signals=”” ) { let jw_ad_tag ​​= {“client”:”googima”,”adscheduleid”:”G7hR9pQ2″,”schedule”:[{“tag”:”https://pubads.g.doubleclick.net/gampad/ads?correlator=&iu=/21698916284/ess/VideoNews&env=vp&gdfp_req=1&output=vast&sz=400×300%7C640x480%7C1000x1%7C1920x1080&description_url=__page-url__&tfcd=0&npa=0&vpmute=1&vpa=auto&vad_type=linear&url=__page-url__&vpos=preroll&unviewed_position_start=1&v=4QHYeDGA&pmnd=0&pmxd=60000&ad_rule=1&cust_params=ttid%3D4QHYeDGA%26frnch%3D__item-franchise__%26environment%3Dproduction%26kwblock%3DAbb%2CCapOne%2CLincoln%2CUPS%2CVG%2CATTCric%2CDisney”,”offset”:”pre”},{“tag”:”https://vid.springserve.com/vast/670880?url=https://www.essence.com/news/watch-cynthia-erivo-on-importance-of-sisterhood/h=450&w=800&cb=1535″,”offset”:”50%”}]”offers”:{“bidders”:[{“id”:”jw-video-4QHYeDGA”,”name”:”jwdemand”,”publisherId”:”evcxFIDZ”,”siteId”:”WT5iFegj”,”placementId”:”24399785″},{“id”:”jw-video-4QHYeDGA”,”name”:”connatix”,”siteId”:”WT5iFegj”,”placementId”:”23419a80-fc77-4fd5-bd0c-2a4807a66a6c”}]”settings”:{“disableConsentManagementOnNoCmp”:true,”mediationLayerAdServer”:”dfp”,”floorPriceCents”:200,”floorPriceCurrency”:”usd”,”buckets”:[{“increment”:0.1,”max”:30,”min”:0},{“increment”:0.5,”max”:50,”min”:30}]}}}; // Configure ad tag on the fly… let additional_params = {}; // Input DVQT signals. if ( dvqt_signals && dvqt_signals.ABS.length > 0 ) { additional_params.ABS = dvqt_signals.ABS.join(“,”); } // Create a string of additional_parameters. let extra_params_str=””; for (enter additional_parameters) { let value = additional_parameters[key]; additional_params_str += `${key}=${value}`; if ( key !== Object.keys( additional_params .pop() ) { additional_params_str += ‘&’; } } // Update ad tag cust_params (must be URL encoded). if ( Object.keys( additional_parameters ). length > 0 ) { let ad_schedule = jw_ad_tag.schedule; if ( ‘undefined’ !== schedule type ads ) { for (let i = 0; i < ad_schedule.length; i++) { let ad_url = new url(jw_ad_tag.schedule[i].label); let query_params = new URLSearchParams(ad_url.search); query_params.set("cust_params", query_params.get("cust_params") + `&${additional_params_str}`); ad_url.search = query_params.toString(); jw_ad_tag.schedule[i].tag = ad_url.toString(); } } } let playerId; if ("undefined" !== type jwplayerQueue) { playerId = 'jw-video-4QHYeDGA'; jwplayerQueue.push({ 'instanceId': 'playerInstance_4QHYeDGA', 'playerId': playerId, 'config': { pid: 't6KP9zcV', playlist: "https://cdn.jwplayer.com/v2/media/4QHYeDGA", autostart: !jw_ad_tag, repeat: true, mute: true, aspect ratio: '16:9', share: {sites: ["facebook", "twitter", "email", "linkedin"]}, cast: {}, float: {disibility: true}, autoPause: {viewability: true}, displaytitle: true, displaydescription: true, controls: true, related: {displayMode: 'shelfWidget'}, interactive: {} , ad: jw_ad_tag ​​​​} }); } // Load video. jQuery(window).trigger("jw:loadplayers"); function waitForJWPlayer(callback) { if (type jwplayer !== 'undefined') { callback(); } else { setTimeout(function() { waitForJWPlayer(callback); }, 500); } } waitForJWPlayer(function() { jwplayer(playerId).on('adsManager', function (adsManagerLoaded) { let adsManager = adsManagerLoaded.adsManager; let videoElement = document.getElementById(playerId ); let config = { anId: '929481' , camp ID: '640x360', ias_xps: "autoplay", // autoplay status ias_xbp: "2", // video destination type ias_xar: "1" // autoplay status }; // Start IAS integration googleImaVansAdapter.init(google, adsManager, videoElement , configuration });

This article was originally published on : www.essence.com
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Health and Wellness

Phenergan is no longer recommended for children under 6 years of age due to the risk of hallucinations. Here’s what you can use instead

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The Australian Drugs Regulatory Authority has issued an order safety warning over Phenergan and related products containing the antihistamine promethazine.

The Therapeutic Goods Administration has stated that over-the-counter products shouldn’t be given to children under six years of age due to concerns about serious unwanted side effects akin to hyperactivity, aggression and hallucinations. Breathing may turn into slow or shallow, which can be fatal.

When high doses are administered to young children, difficulties in learning and understanding, including reversible cognitive deficit and mental disability, may occur. – said the TGA.

The latest warning follows international and Australian concerns about the drug in young children, which is commonly used to treat conditions akin to hay fever and allergies, motion sickness and for short-term sedative effects.

What is promethazine?

Promethazine is a “first generation” antihistamine that has been sold over the counter in Australian pharmacies for a long time for a spread of conditions.

Unlike many other drugs, first-generation antihistamines can cross the blood-brain barrier. This means they affect your brain chemistry, making you feel drowsy and sedated.

In adults, this will likely be useful for sleep. However, in children, these drugs can cause serious unwanted side effects on the nervous system, including those mentioned on this week’s safety alert.

We’ve known about this for a while

We have known about the serious unwanted side effects of promethazine in young children for a while.

Advice regarding 20 years ago In the United States, the drug was not recommended for use in children under two years of age. In 2022, an Australian Medicines Advisory Committee made its own suggestion to increase the age to six. New Zealand released similar warnings and advice in May this 12 months.

Over the last ten years, there have been 235 cases of serious unwanted side effects from promethazine in each children and adults reported to the TGA. Of the 77 deaths reported, one was a toddler under six years of age.

Reported unwanted side effects in each adults and children included:

  • 13 cases of accidental overdose (leading to 11 deaths)
  • eight cases of hallucinations
  • seven cases of slow or shallow respiration (leading to 4 deaths)
  • six cases of decreased consciousness (leading to five deaths).

TGA security alert comes after an internal investigation by the manufacturer of Phenergan, Sanofi-Aventis Healthcare. This investigation was initiated in 2022 advice from the Medicines Advisory Committee. The company has now updated its information for consumers and healthcare professionals.

What can you use instead?

If you have allergies or hay fever in young children, non-sedating antihistamines akin to Claratine (loratadine) or Zyrtec (cetirizine) are preferred. They provide relief without the risk of sedation and other disturbing unwanted side effects of promethazine.

If symptoms of a chilly or cough occur, parents must be reassured that these symptoms will normally subside with time, fluid intake, and rest.

Saline nasal sprays, adequate hydration, a humidifier or elevating the child’s head can relieve the congestion related to hay fever. Oral products containing phenylephrine marketed for nasal congestion must be avoided because evidence shows that this is the case This article was originally published on : theconversation.com

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