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Are you considering taking a weight loss drug like Ozempic? Here are some potential risks and benefits

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When weight loss drugs like Ozempic appeared available on the market, celebrities and social media influencers quickly began reaping their benefits, resulting in a rapid increase of their use. In the last three months of 2022, doctors within the United States alone wrote over nine million prescriptions for these drugs.

As their popularity has increased, we have also heard more about their potential unwanted effects, from common gastrointestinal complaints to more serious mental health issues.

But what does the science say about how well Ozempic and Wegovy (each brand names of the drug semaglutide) work for weight loss? What are the potential unwanted effects? Here’s what to contemplate if you or a loved one is fascinated with taking the drug.



Possible profits

1) It will probably help you lose weight

The largest, well run Research work semaglutide originated within the UK in 2021. About 1,961 people classified as “overweight” or “obese” were randomly assigned to receive semaglutide or placebo and were followed for 68 weeks (about 1.3 years). All participants also had free access to advice on healthy eating and physical activity.

The study showed that individuals taking semaglutide lost weight – significantly greater than those taking placebo (-14.9% of body weight compared with -2.4% of body weight).

In one other test within the United States, one medical practice administered weekly injections of semaglutide to 408 people. During the primary three months, the people included in the ultimate evaluation (175 people) lost a mean of 6.7 kg. They lost a mean of 12.3 kg in the primary six months.

Significant weight loss was observed in additional people recent trial semaglutide, suggesting that weight loss is a very likely consequence of continued use of the drug.

On average, people taking semaglutide within the study lost just below 15% of their body weight, compared with 2.4% for those taking placebo.
John Hanson Pye/Shutterstock

2) It can reduce risk aspects for chronic diseases

When chubby or obese people lose weight at the least 5% body weight, physiological changes often transcend changes in body weight or shape. This may include lowered levels of cholesterol, lowered blood pressure and lowered blood glucose levels, which reduces the chance of chronic diseases.

In one in all semaglutide trialsmost individuals (87.3%) lost at the least 5% of their body weight. Although most large studies of semaglutide excluded individuals with metabolic diseases comparable to type 2 diabetes, the metabolic health benefits were noticedincluding decreased blood pressure, blood glucose and fasting blood lipids (fats).

IN UK test as of 2021, people taking semaglutide saw greater improvements in physical performance and risk aspects for heart disease and diabetes, including reductions in waist circumference, reductions in markers of inflammation, blood pressure and blood glucose levels.

3) It can improve your quality of life, emotional well-being, or sense of accomplishment

The original study of semaglutide didn’t deal with this bundle of benefits, but follow-up studies have shown additional benefits related to the drug. Compared to placebo, people taking semaglutide saw significant improvement improvements of their physical functioning and of their perception of their overall health, social functioning and mental health.

Anecdotally (not based on scientific research), people using semaglutide, e.g Oprah Winfreyreport a moment of recovery or a turning point in your life, social situation and body image.

Oprah Winfrey at a recent awards ceremony
Oprah says Ozempic quieted her “food noise.”
Chris Pizzello/AAP

What concerning the risks?

1) Gastrointestinal symptoms may occur

In Clinical trial within the USAalmost half (48.6%) of individuals taking semaglutide reported unwanted effects. The commonest symptoms were nausea and vomiting (36.6%), followed by diarrhea (8.6%), fatigue (6.3%), and constipation (5.7%).

Nausea and diarrhea were also commonly reported within the UK study.

IN next try, many participants (74.2%) using semaglutide reported gastrointestinal symptoms. However, almost half (47.9%) of placebo users also reported gastrointestinal symptoms, indicating that symptoms could also be just like those experienced during normal, on a regular basis life.

Most gastrointestinal symptoms were mild to moderate in severity and resolved without discontinuation in most subjects.

2) You may feel drained

Fatigue was the second commonest side effect amongst US participants clinical examinationaffecting 6.3% of participants.

A person holds an Ozempic injection
The commonest symptoms are gastrointestinal symptoms, followed by fatigue.
fcm82/Shutterstock

3) You could also be within the minority who cannot tolerate the drug

The Australian Therapeutic Goods Agency (TGA) yes approved Ozempic as protected for treating type 2 diabetes, but not yet approved to be used for weight loss. TGA has it too approved Wegovy (higher dose semagtlutide) for weight loss, nevertheless it is just not yet available in Australia.

In United States clinical examinationNo unexpected issues of safety were reported. However, five patients (2.9%) needed to stop taking the drug because they might not tolerate the unwanted effects. Fifteen (8.6%) needed to either reduce their dose or stay on the identical dose to avoid unwanted effects.

IN other researchsome patients discontinued the study because their gastrointestinal symptoms were so severe that they might not tolerate further treatment.

More serious safety concerns have been reported in studies include gallbladder-related disease (mainly cholelithiasis, also often called gallstones) in 34 patients (2.6%) and mild acute pancreatitis in three patients (0.2%). All subjects recovered through the trial period.

European 2024 test analyzed psychiatric opposed events related to the usage of semaglutide, liraglutide, and tirzepatide (which act in a similar strategy to semaglutide). In the period from January 2021 to May 2023, 481 psychiatric events (roughly 1.2% of all reported) related to those drugs were registered within the drug database. About half of those events were reported as depression, followed by anxiety (39%) and suicidal ideation (19.6%). Nine deaths and 11 life-threatening cases were reported through the study period.

Due to the seriousness and dire consequences of some of those reports, US Food and Drug Administration further studies were carried out, but no evidence was found that the usage of these drugs causes suicidal thoughts or actions.

4) Access could also be difficult

Despite being considered protected, the TGA is warned significant barriers to access to Ozempic feedstock are more likely to remain throughout 2024.

To address shortages, pharmacists should give preference to individuals with type 2 diabetes searching for the drug.

5) You cannot at all times get clear information from special interests

Given the recognition of Ozempic and Wegova, health organizations comparable to the World Obesity Federation have expressed this apprehension about drug marketing, PR and power presence on social media.

Some journalists are like that raised concerns about conflict of interest on the connection between some obesity researchers and the manufacturers of Novo Nordrisk, Ozempic and Wegovy. There is concern that the connection with Novo Nordrisk could influence researchers to provide trial results that are more favorable to the drugs.

Conclusion

Ozempic is a medicine that ought to be used together with your doctor. Remember, nevertheless, that weight is simply one aspect of your health and well-being. It’s vital to have a look at your health holistically and prioritize eating well, exercising more, and getting enough sleep.


This article was originally published on : theconversation.com
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Health and Wellness

Heart of the City: Go-Go Museum and Café Honor DC’s Musical Legacy – Essence

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WASHINGTON, DC – FEBRUARY 19: Janet Purnell waits in line at a community event to sign laws recognizing Go-Go music as the official music of DC at Culture House in Washington, DC, Wednesday, Feb. 19, 2020. DC Council Member Kenyon McDuffie, Ward 5, wrote the laws, which calls for a program to support, preserve and archive Go-Go music and its history. “I’ve been here for 30 years and I loved it when I first heard it,” Purnell said. “I love Chuck Brown.” (Photo by Jahi Chikwendiu/The Washington Post via Getty Images)

The heart of Washington beats to its own rhythm – go-go music. Now, for the first time, that sound has a everlasting home in the recent Go-Go Museum and Cafe in Anacostia, ensuring that DC’s most iconic cultural product is revered for generations to come back.

Go-go, a novel combination of funk, rhythm and drums, born in the streets and clubs Washington in the Seventieshas been a driving force in the city for a long time. Now it has a everlasting home where its legacy will proceed to encourage generations to come back.

The team behind the highly anticipated Go-Go Museum & Cafe is about to carry a ribbon-cutting ceremony in Washington’s historic Anacostia District on November 18, marking the opening of the first institution dedicated to celebrating and preserving go-go—the syncopated, drum-driven funk that has change into the heart of D.C.’s cultural identity.

Heart of the City: Go-Go Museum and Café Pays Tribute to DC's Musical Heritage

Go-go music is greater than only a genre—it’s a culture, a movement, and an undeniable source of pride for DC, especially the black community. Rooted in its syncopated rhythms and live performances, go-go has been the soundtrack to countless DC street parties, political protests, and neighborhood gatherings. It’s change into official city music in 2019cementing its cultural significance not just for Washingtonians but for the world. And now, with the opening of the Go-Go Museum, the genre’s influence will be preserved and celebrated.

The Go-Go Museum and Café is the brainchild of community organizer and go-go promoter Ron Moten, who helped lead #DontMuteDC Movement—a watershed moment in 2019 that defended the city’s musical identity from erasure. What began as a protest against the continued performance of go-go music in public spaces has blossomed right into a broader effort to guard and preserve DC’s unique cultural heritage. Moten, together with co-founder and museum curator Dr. Natalie Hopkinson, has made that vision a reality, giving go-go music the attention it has long deserved.

Located at 1920 Martin Luther King Jr. Blvd SE in the heart of historic Anacostia, the museum will feature interactive exhibits, live performances and artifacts that tell the story of go-go’s rise from an area sound to global recognition. Visitors can look forward to finding memorabilia like DJ Kool’s concert jacket, a Chuck Brown promotional cutout and a rare bomber jacket from iconic band Rare Essence. The space may also be equipped with cutting-edge technology, including holograms of go-go legends like Anwan Glover of the Backyard Band.

For the D.C. community, the museum is greater than just an area—it’s a testament to the enduring power of go-go music and its role in shaping the city’s identity. “We wanted to create a space where the community could come together to celebrate and experience go-go in all its glory,” Moten explained. With a recording studio, outdoor stage, and coffee shop, the Go-Go Museum is about to change into a vibrant cultural hub, ensuring that the infectious rhythm of go-go continues to thrive.

As the museum prepares for its official opening in January and special events are planned in November to have a good time Go-Go Heritage Preservation Week, one thing is obvious: the rhythms of DC’s go-go won’t ever again be silent.


This article was originally published on : www.essence.com
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Health and Wellness

Halle Berry Wants to Improve Intimacy for Menopausal Women with New Products

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Douglas Evans

Halle Berry takes her passion for women’s health and wellness to the subsequent level.

The star actress, producer and director has been refreshingly honest about her harrowing personal experience with severe perimenopause symptoms and her desire to break down the stigma and taboo surrounding the midlife experience for women. Now, she’s reshaping her wellness platform, ANSWERto give attention to making a community of support and resources, including products, for women going through “the transition” and people who want to be prepared for what lies ahead.

“I know it’s my responsibility to use my voice and my platform to talk about these issues,” Berry tells ESSENCE exclusively. “It’s important that I create a safe community space for women to share, learn, and empower themselves.”

“That, along with cutting-edge products for women, is exactly the kind of support I want,” she continues. “Products that are backed by science and created by experts—that’s what makes all the difference.”

Exclusive: Halle Berry aims to improve intimacy for menopausal women with groundbreaking new products
Douglas Evans

Berry’s first foray into support products comes as a part of her platform’s recently announced partnership with Joy, a worldwide leader in intimate wellness. RESPIN and Joylux have entered right into a multi-faceted partnership to serve menopausal and perimenopausal/postmenopausal women affected by common intimate health issues. Their first collaboration comes via two revolutionary products – a brand new intimate gel and a special, award-winning edition of the vFit+ device.

“What excites me most is the opportunity to really change the conversation around menopause and midlife health. It’s been a topic that’s been overlooked for too long,” she says. “The opportunity to work with a company like Joylux to create products that really work and help women regain their confidence.”

RESPIN Partnership with Joylux was built organically because Berry turned to the brand at a time of need. Struck by vaginal dryness that resulted in painful intercourse as a side effect of perimenopause—initially misdiagnosed as herpes—the Oscar winner sought answers and shortly found solutions designed by Joylux obstetricians and gynecologists. Her experience was so positive that she decided to spend money on and ultimately partner with Joylux through its RESPIN platform to collaborate on products that enhance intimacy during this incredibly vital time in a lady’s life.

Exclusive: Halle Berry aims to improve intimacy for menopausal women with groundbreaking new products
Douglas Evans

This LET’S SPIN intimate gel offers unparalleled hydration, comfort and pleasure. Packaged in an elegantly designed, recyclable glass bottle with a deep red, luxurious matte finish, the product looks more like an expensive face cream that belongs on the nightstand than the everyday gels that you simply often discreetly grab from the pharmacy and conceal in the medication cabinet.

RESPIN worked closely with Joylux Ob-Gyn Sarah de la Torre, MD, to develop and test the product for over a yr. Ultimately, they created a formula enriched with hyaluronic acid and aloe, pH-balanced for delicate skin, and formulated with pure ingredients freed from parabens, PEGs, and glycerin that Berry says “changed her life.” Although it was developed with the needs of ladies in various stages of menopause in mind, LET’S SPIN elevates intimacy for everyone, no matter age, gender, or stage of life.

“After years of dedication to creating products that improve women’s lives, it was so empowering to receive the call from Halle and RESPIN,” said Colette Courtion, founder and CEO of Joylux, in a press release. “Through Halle’s powerful voice, her advocacy, and the RESPIN platform, we are able to amplify our message and reach millions of women who want to improve their health and well-being. LET’S SPIN is a product for everyone.”

Exclusive: Halle Berry aims to improve intimacy for menopausal women with groundbreaking new products
Douglas Evans

In addition to the gel, Berry also provided personal input that helped develop Intimate wellness device RESPIN x Joylux vFit+ Red Lighta special menopause kit with a chrome finish and a particular silver storage bag. Using advanced red light and thermal energy technology, the device allows users to promote hydration, improved sensations and higher pelvic floor health within the comfort of their very own home. Previously available only through doctors, this luxury home-use device provides noticeable improvements after just a number of weeks of standard use, boosting confidence and enhancing intimacy.

RESPIN X JOYLUX LET’S SPIN Intimate Gel ($45) and vFit+ Red Light Intimate Wellness Device ($495) will probably be available on September 24, 2024 at joylux.com and at more online retailers this fall, including RESPIN, Nordstrom, Bloomingdales, Ulta, Neiman Marcus, Goop, Amazon and choose physician practices. It may even be available globally in Canada and the UK through select partners.

Exclusive: Halle Berry aims to improve intimacy for menopausal women with groundbreaking new products
Douglas Evans

Of course, the launch of this product is just the primary of many exciting developments for Berry and RESPIN. With the goal of empowering women to embrace this natural change and take away the shame associated with aging into femininity at the guts of her mission, the actress hopes that girls will probably be inspired by the everlasting beauty that comes with this stage of life.

“As the RESPIN community grows, I would like to connect with more women, help them feel more confident to talk about their experiences, and give them the tools they need to feel confident, healthy, and celebrated,” she says.

This article was originally published on : www.essence.com
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Health and Wellness

Climate change is a pollution problem, and countries know how to deal with pollution threats – think DDT and acid rain

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Climate change could seem insurmountable. But if you happen to take a closer have a look at its causes, you realize that history is stuffed with similar health and environmental threats that humanity has overcome.

The predominant explanation for climate change is carbon dioxide produced by burning fossil fuels – is just one other pollutant. And countries know how to reduce harmful pollutants. They did so with the pesticide DDT, lead paint, and power plant emissions that caused acid rain, amongst many others.

In each case, growing public outcry eventually led to policy changes, despite industry resistance. Under pressure from laws and regulations, industry ramped up production of safer alternatives.

I’m earth and environmental scientistand my latest book “Reclaiming our planet,” explores the teachings of history in overcoming seemingly insurmountable threats. Here are some examples:

DDT ban despite industry opposition

DDT was the primary truly effective pesticide and considered miraculous. Killing mosquitoes and lice, eliminated malaria and other diseases in lots of countries, and in agriculture it saved tons of crops.

After World War II, DDT was utilized in farms, buildings and gardens throughout the United States. However, it also had its drawbacks. accumulated in mother’s milk to levels that would deliver a toxic dose to infants. Women were It was discouraged breastfed their children within the Sixties due to the risks.

The American bald eagle population was decimated by DDT. After the chemical was banned, the eagles began to get better.
United States Fish and Wildlife Service

In addition, DDT bioaccumulated within the food chain to toxic levels in peak species reminiscent of raptors. This weakened eggshells to the purpose that brood moms crushed their eggs. White-tailed eagles were reduced to 417 breeding pairs throughout North America by 1967 and were placed on the endangered species list.

Biologist Rachel Carson documented the damage DDT caused to her body 1962 book “Silent Spring”“and thus launched the general public environmental movement. Despite disinformation campaigns and attacks from the chemical industry, enormous social pressure on politicians led to congressional hearings, state and federal restrictions and finally the USA ban on the overall use of DDT in 1972.

A woman speaks at a table in front of several microphones during a congressional hearing.
Rachel Carson, whose book “Silent Spring” pioneered pesticide research, testifies before a Senate committee in Washington, D.C., June 4, 1963.
AP Photo/Charles Gorry

White-tailed Eagles recovered up to 320,000 within the United States by 2017, in regards to the same because the population before European settlement. The chemical industry, faced with the ban on DDT, quickly developed much safer pesticides.

Gathering evidence on the risks of lead

Application of lead increased dramatically within the twentieth centuryespecially in paints, plumbing and gasoline. It was so common that nearly everyone was exposed to metal that, according to research, could also be harmful the kid’s kidneys, liver, cardiovascular system and brain development.

Clair “Pat” Patterson, a geochemist on the California Institute of Technology, has shown that Americans were continually exposed to lead at near toxic levels. Human skeletons from the Sixties were found to have up to 1200 times lead of ancient skeletons. Today health standards say that it is no protected level of lead within the blood.

Older home with peeling paint on exterior walls behind porch. Construction equipment is on a new step that is being built on porch.
Lead-based paint was banned for home use within the U.S. in 1978, but lead paint present in older homes can still chip, posing a health risk to children.
Environmental Protection Agency

Despite threats each personal and skilled, and an industry disinformation campaign, Patterson and his supporters evidence has been collected from years warn the general public and ultimately pressure politicians to ban the usage of lead in lots of applications, including petrol AND residential paints.

After the regulations were introduced, the industry accelerated production of substitutesAs a result, the extent of lead within the blood of kids reduced by 97% over the following few a long time. Although lead exposure is now less common, some persons are still exposed to dangerous levels present in homes, pipes and soil, often in low-income neighborhoods.

Stopping Acid Rain: An International Concern

Acid rain is primarily brought on by the discharge of sulfur dioxide into the air in the course of the burning of coal, high-sulfur oil, and the smelting and refining of metals. interacts with rain or fogThe acid rain that falls can destroy forests, kill lake ecosystems, dissolve monuments and corrode infrastructure.

The damage brought on by acid rain in Europe and North America within the twentieth century showed the world that air pollution, which is not limited to national borders, can grow to be a world crisis requiring international solutions.

The problem of acid rain began greater than a hundred years ago, but sulfur dioxide levels grew rapidly after World War IIIn 1952, a thermal inversion occurred in London, which resulted within the concentration of sulfur dioxide and other air pollutants being so high that killed 1000’s of individualsAs damage to forests and lakes worsened across Europe, countries signed international agreements In the Eighties, actions were taken to reduce sulfur dioxide emissions.

A forest with many trees without the needs of pines.
Trees died as a results of acid rain within the Czech Republic in 1998. Forests in lots of parts of Europe and North America have suffered damage from acid rain.
Photo by Seitz/ullstein via Getty Images

In the US, emissions from Midwestern power plants killed fish and trees within the pristine Adirondacks. The destruction, health problems and quite a few disasters outraged public opinion, to which politicians responded.

Sulfur dioxide listed as certainly one of six criteria for air pollution in groundbreaking study U.S. Clean Air Act of 1970which required the federal government to set limits on its release. Power plants scrubbers installed to capture pollution and over the following 40 years, the concentration of sulfur dioxide within the U.S. reduced by about 95%.

Parallels with climate change

There are many similarities between these examples and climate change today.

Mountains scientific evidence show how carbon dioxide emissions are created by burning fossil fuels in vehicles, factories and power plants They are warming the planetThe fossil fuel industry has begun to exploit its political power AND disinformation campaigns a long time ago to block regulations the aim of which was to decelerate climate change.

People all around the world are struggling with increasing heat and weather disasters brought on by global warming. calling for motion to stop climate change and spend money on cleaner energy.

First Earth Dayin 1970, it attracted 20 million people. Recent years have seen a change in attitudes towards climate change and attracted hundreds of thousands people all around the world.

The street was packed with people, many holding signs calling on the Biden administration to take action on climate change.
Public campaigns and mass demonstrations to combat climate change, reminiscent of the one in New York in 2023, help to put social pressure on politicians.
Erik McGregor/LightRocket via Getty Images

The challenge was to get politicians to act, but that is is slowly changing in lots of countries.

The United States has begun investing in scaling up several tools to mitigate climate changeincluding electric vehicles, wind turbines and solar panels. Federal and state policies reminiscent of requirements for renewable energy production and reducing greenhouse gas emissions are also key to pushing industries to switch to less harmful alternatives.

Climate change is a global problem that may require worldwide motion. International agreements are also helping more countries take steps forward. One change that countries have been discussing for years could help bolster those efforts: ending billions of dollars in taxpayer-funded fossil fuel subsidies and allocating these funds to healthier solutions could help decelerate climate change.

This article was originally published on : theconversation.com
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