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Are you considering taking a weight loss drug like Ozempic? Here are some potential risks and benefits

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When weight loss drugs like Ozempic appeared available on the market, celebrities and social media influencers quickly began reaping their benefits, resulting in a rapid increase of their use. In the last three months of 2022, doctors within the United States alone wrote over nine million prescriptions for these drugs.

As their popularity has increased, we have also heard more about their potential unwanted effects, from common gastrointestinal complaints to more serious mental health issues.

But what does the science say about how well Ozempic and Wegovy (each brand names of the drug semaglutide) work for weight loss? What are the potential unwanted effects? Here’s what to contemplate if you or a loved one is fascinated with taking the drug.



Possible profits

1) It will probably help you lose weight

The largest, well run Research work semaglutide originated within the UK in 2021. About 1,961 people classified as “overweight” or “obese” were randomly assigned to receive semaglutide or placebo and were followed for 68 weeks (about 1.3 years). All participants also had free access to advice on healthy eating and physical activity.

The study showed that individuals taking semaglutide lost weight – significantly greater than those taking placebo (-14.9% of body weight compared with -2.4% of body weight).

In one other test within the United States, one medical practice administered weekly injections of semaglutide to 408 people. During the primary three months, the people included in the ultimate evaluation (175 people) lost a mean of 6.7 kg. They lost a mean of 12.3 kg in the primary six months.

Significant weight loss was observed in additional people recent trial semaglutide, suggesting that weight loss is a very likely consequence of continued use of the drug.

On average, people taking semaglutide within the study lost just below 15% of their body weight, compared with 2.4% for those taking placebo.
John Hanson Pye/Shutterstock

2) It can reduce risk aspects for chronic diseases

When chubby or obese people lose weight at the least 5% body weight, physiological changes often transcend changes in body weight or shape. This may include lowered levels of cholesterol, lowered blood pressure and lowered blood glucose levels, which reduces the chance of chronic diseases.

In one in all semaglutide trialsmost individuals (87.3%) lost at the least 5% of their body weight. Although most large studies of semaglutide excluded individuals with metabolic diseases comparable to type 2 diabetes, the metabolic health benefits were noticedincluding decreased blood pressure, blood glucose and fasting blood lipids (fats).

IN UK test as of 2021, people taking semaglutide saw greater improvements in physical performance and risk aspects for heart disease and diabetes, including reductions in waist circumference, reductions in markers of inflammation, blood pressure and blood glucose levels.

3) It can improve your quality of life, emotional well-being, or sense of accomplishment

The original study of semaglutide didn’t deal with this bundle of benefits, but follow-up studies have shown additional benefits related to the drug. Compared to placebo, people taking semaglutide saw significant improvement improvements of their physical functioning and of their perception of their overall health, social functioning and mental health.

Anecdotally (not based on scientific research), people using semaglutide, e.g Oprah Winfreyreport a moment of recovery or a turning point in your life, social situation and body image.

Oprah Winfrey at a recent awards ceremony
Oprah says Ozempic quieted her “food noise.”
Chris Pizzello/AAP

What concerning the risks?

1) Gastrointestinal symptoms may occur

In Clinical trial within the USAalmost half (48.6%) of individuals taking semaglutide reported unwanted effects. The commonest symptoms were nausea and vomiting (36.6%), followed by diarrhea (8.6%), fatigue (6.3%), and constipation (5.7%).

Nausea and diarrhea were also commonly reported within the UK study.

IN next try, many participants (74.2%) using semaglutide reported gastrointestinal symptoms. However, almost half (47.9%) of placebo users also reported gastrointestinal symptoms, indicating that symptoms could also be just like those experienced during normal, on a regular basis life.

Most gastrointestinal symptoms were mild to moderate in severity and resolved without discontinuation in most subjects.

2) You may feel drained

Fatigue was the second commonest side effect amongst US participants clinical examinationaffecting 6.3% of participants.

A person holds an Ozempic injection
The commonest symptoms are gastrointestinal symptoms, followed by fatigue.
fcm82/Shutterstock

3) You could also be within the minority who cannot tolerate the drug

The Australian Therapeutic Goods Agency (TGA) yes approved Ozempic as protected for treating type 2 diabetes, but not yet approved to be used for weight loss. TGA has it too approved Wegovy (higher dose semagtlutide) for weight loss, nevertheless it is just not yet available in Australia.

In United States clinical examinationNo unexpected issues of safety were reported. However, five patients (2.9%) needed to stop taking the drug because they might not tolerate the unwanted effects. Fifteen (8.6%) needed to either reduce their dose or stay on the identical dose to avoid unwanted effects.

IN other researchsome patients discontinued the study because their gastrointestinal symptoms were so severe that they might not tolerate further treatment.

More serious safety concerns have been reported in studies include gallbladder-related disease (mainly cholelithiasis, also often called gallstones) in 34 patients (2.6%) and mild acute pancreatitis in three patients (0.2%). All subjects recovered through the trial period.

European 2024 test analyzed psychiatric opposed events related to the usage of semaglutide, liraglutide, and tirzepatide (which act in a similar strategy to semaglutide). In the period from January 2021 to May 2023, 481 psychiatric events (roughly 1.2% of all reported) related to those drugs were registered within the drug database. About half of those events were reported as depression, followed by anxiety (39%) and suicidal ideation (19.6%). Nine deaths and 11 life-threatening cases were reported through the study period.

Due to the seriousness and dire consequences of some of those reports, US Food and Drug Administration further studies were carried out, but no evidence was found that the usage of these drugs causes suicidal thoughts or actions.

4) Access could also be difficult

Despite being considered protected, the TGA is warned significant barriers to access to Ozempic feedstock are more likely to remain throughout 2024.

To address shortages, pharmacists should give preference to individuals with type 2 diabetes searching for the drug.

5) You cannot at all times get clear information from special interests

Given the recognition of Ozempic and Wegova, health organizations comparable to the World Obesity Federation have expressed this apprehension about drug marketing, PR and power presence on social media.

Some journalists are like that raised concerns about conflict of interest on the connection between some obesity researchers and the manufacturers of Novo Nordrisk, Ozempic and Wegovy. There is concern that the connection with Novo Nordrisk could influence researchers to provide trial results that are more favorable to the drugs.

Conclusion

Ozempic is a medicine that ought to be used together with your doctor. Remember, nevertheless, that weight is simply one aspect of your health and well-being. It’s vital to have a look at your health holistically and prioritize eating well, exercising more, and getting enough sleep.


This article was originally published on : theconversation.com
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Health and Wellness

Essence of the week: Cherry Blossom EDT L’Occitane is a fragrance inspired by spring, perfect for any season – Essence

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We all know L’Occitane almond shower oil gets a lot of love – and for good reason (I’m taking a look at you #BeautyTok).

But there is one other gem of this brand that deserves just as much attention: Cherry Blossom Eau de Toilette. Since its launch in 2007, this fragrance has remained a favorite amongst my group of friends, appreciated for its delicate and refined elegance. To be honest, I feel this is what L’Occitane is known for as a brand. And although this scent is often related to the airy freshness of spring, it is a scent that brings a touch of beauty and heat to any season.

The first spritz of Cherry Blossom EDT is soft and alluring, with a subtle hint of cherry and freesia that feels fresh without overdoing it. It’s light and uplifting, like the kind of scent you employ when you would like to feel good but not an excessive amount of (like me most days). As it settles on my skin, notes of cherry blossom and lily of the valley bloom, striking the perfect balance of femininity without feeling overly sweet or dated. There’s nothing heavy or “old school floral” about this scent – it’s fresh, modern and understated in a way that feels sophisticated.

What really makes this fragrance stand out is the base. Brazilian rosewood, amber and musk give it a soft warmth that wraps you want your favorite cashmere scarf. It’s cozy but never heavy, beautifully balancing the delicate flowers. The overall effect is a scent that feels effortlessly polished – the olfactory equivalent of “quiet luxury.”

I do know, I do know – cherry blossoms evoke spring, but that is why this scent works so well all 12 months round. In the colder months, it is a refreshing break from heavy, spicy scents. I mean, I like my ouds and cognacs, but no… Bright notes of cherry and freesia bring a breath of fresh air, while warm base notes of amber and musk give the composition a comforting, grounded feel. It’s like carrying a little bit of spring with you, even when the weather is not sunny. And given the conflicting rumors we’re hearing – at the very least on the East Coast – about how much snow will fall this season, you would possibly just should keep it in your radar.

Why I find it irresistible: While everyone gravitates towards the Almond L’Occitane collection, their EDT Cherry Blossom has turn out to be an unexpected favorite of mine that I still reach for. What I like most about it is how versatile it is. It’s lightweight enough to accommodate skilled meetings or running errands during the day, but still feels special enough for dinner dates or quiet moments at home. The way it evolves on the skin – from a fresh, floral burst to a soft, warm texture – makes it feel personal, like a fragrance created just for you. It’s not flashy or trendy, but that is what makes it timeless.

Perfect pairs: As an eau de toilette, Cherry Blossom advantages greatly from thoughtful layering that highlights its delicate character and prolongs its presence throughout the day. And because Cherry Blossom has a softer sillage, it’s perfect for on a regular basis wear. If you would like to extend its durability or make it a bit more dynamic, layering is the best solution. Start with L’Occitane Cherry Blossom Shower Oil to create a fragrant base, then follow with the Shimmering Body Milk for extra depth and hydration.

If you wish to mix and match, pair Cherry Blossom EDT with complementary fragrances. Kayali Vanilla 28 adds a cozy sweetness that blends beautifully with the floral notes, while Commodity Milk+ brings out the creamy warmth of the base. On the fun side, the marshmallow and ambrette notes of Ellis Brooklyn SWEET add a delicate, sweet touch that prolongs the persistence of the cherry blossom accord. Spray the fragrance base first, let it settle, after which top with cherry blossom for a custom scent that can last all day.

EDT Cherry Blossom by L’Occitane is a masterclass in subtle sophistication. Founder Olivier Baussan put it perfectly: “It is because cherry blossoms fly away with the first breath of spring that they are so rare and precious.” This fragrance captures ephemeral beauty in a bottle. Final Verdict: If you appreciate fragrances that whisper slightly than shout, that talk of sophistication slightly than trends, L’Occitane’s Cherry Blossom EDT is value considering. It’s the olfactory equivalent of finding the perfect light – subtle, beautiful and absolutely fascinating.

Fragrance is deeply personal, but some fragrances gain universal appeal due to their masterful composition. This is one of them.

This article was originally published on : www.essence.com
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Health and Wellness

You don’t have to add sugar to your cranberry sauce this holiday season – a food scientist explains how to cook with less sweeteners

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Holidays are stuffed with tasty and filling dishes and drinks. It’s hard to resist dreams of cookies, special cakes, wealthy meats and exceptionally spicy additions.

Many of the healthy ingredients utilized in holiday dishes could be overshadowed by sugar and starch. While adding extra sugar could also be tasty, it isn’t necessarily good for your metabolism. Understanding the food and cuisine science behind what you cook means you may make a few changes to a recipe and still have a delicious dish that won’t loaded with sugar.

Especially for those who’re someone with type 1 diabetes, the vacations can come with an additional layer of stress and soaring blood glucose levels. However, this just isn’t the time to despair – it’s the vacations in spite of everything.

Cranberries are a seasonal, tasty fruit that could be tweaked in recipes to make them more Type 1 diabetic-friendly – or friendly to anyone searching for a sweet dish without the added sugar.

I’m a food scientist and sort 1 diabetes. Understanding food composition, ingredient interactions, and metabolism literally saved my life.

Type 1 diabetes has been defined

Type 1 diabetes it lasts all day, without sleep breaks, without holidays and weekends, without remission and without cure. Type 1 diabetes don’t produce insulin, a hormone essential for all times, which promote the absorption of glucose, i.e. sugar, into cells. Glucose in your cells then provides the body with energy on the molecular level.

Therefore, people with type 1 diabetes take insulin injections using an insulin pump attached to their bodies and hopefully it really works well enough to stabilize our blood sugar levels and metabolism, minimize health complications over time, and keep us alive.

Type 1 diabetics have in mind mainly type and amount of carbohydrates in food when determining how much insulin to take, but in addition they need to understand the interactions of proteins and fats in food to use it, or bolusappropriately.

Apart from insulin, type 1 diabetics don’t produce one other hormone, amylin, which slows down gastric motility. This means food moves faster through our digestive tract and we regularly feel very hungry. Foods high in fat, protein and fiber can keep you from feeling hungry for a while.

Cranberries, a seasonal snack

Cranberries are native to North America and grow well within the northeastern and midwestern states, where they’re in season from late September through December. They dominate holiday tables everywhere in the country.

Cranberries are a classic Thanksgiving side dish, but cranberry sauce tends to be high in sugar.
bhofack2/iStock via Getty Images

One cup of whole, raw cranberries comprises 190 calories. They are composed of 87% water, trace amounts of protein and fat, 12 grams of carbohydrates and just over 4 grams of soluble fiber. Soluble fiber combines well with water, which is sweet for digestive health and might slow the rise in blood glucose levels.

Cranberries are tall IN potassiumwhich helps maintain electrolyte balance and cell signaling, in addition to other essential nutrients similar to antioxidants, beta-carotene AND vitamin C. They also contain vitamin Kwhich helps in healthy blood clotting.

The taste and aroma of cranberries comes from compounds present in fruits similar to cinnamates, which add a hint of cinnamon, vanillin for a vanilla note, benzoates AND Benzaldehydethat tastes like almonds.

Cranberries are high in pectin, a soluble starch that forms a gel and is used as a binding agent in making jams and jellies, in order that they thicken easily with minimal cooking. Their beautiful jewel tone red color belongs to a class of compounds called anthocyanins and proanthocyanidins with which they’re associated treating certain forms of infections.

They also contain phenols, that are protective compounds produced by the plant. These compounds, which appear like rings on the molecular level, interact with proteins within the saliva, causing a dry and tight feeling that causes the mouth to pucker. Similarly, the so-called benzoic acid naturally occurring in cranberries, it adds sourness to the fruit.

These chemical components make them extremely sour and bitter and difficult to eat raw. To moderate these flavors and effects, most cranberry recipes call for plenty of sugar.

All this extra sugar could make cranberry dishes difficult for type 1 diabetics to devour since the sugars cause blood glucose levels to rise quickly.

Cranberries without sugar?

Type 1 diabetics – or anyone looking to limit their sugar intake – can try some cooking tactics to reduce their sugar intake while still having fun with this holiday treat.

Don’t cook the cranberries too long once they pop. You’ll still have a sticky cranberry liquid without having to add a lot of sugar, because cooking concentrates a number of the bitter compounds, making them more visible within the dish.

A row of spoons, each filled with a pile of powdered spice.
Adding spices to cranberries can improve the flavour of the dish without the added sugar.
klenova/iStock via Getty Images

The addition of cinnamon, cloves, cardamom, nutmeg and other warming spices gives the dish a depth of flavor. Adding heat with hot chili pepper it might make a cranberry dish more complex while reducing sourness and astringency. Adding salt can reduce the bitterness of cranberries, so you will not need a lot of sugar.

For a richer flavor and glossy quality, add butter. The butter also moisturizes the lips, which reinforces the natural tartness of the dish. Other fats, similar to cream or coconut oil, also work.

Adding chopped walnuts, almonds or hazelnuts may decelerate the absorption of glucose, so your blood glucose levels may not rise as quickly. Some recent forms of sweeteners, similar to allulosethey taste sweet but don’t raise blood sugar levels and require minimal or no insulin. Allulose has GRAS – Generally Regarded as Safe – status within the US but just isn’t approved as an additive in Europe.

During the holiday season, you may easily reduce the quantity of sugar added to cranberry dishes and revel in the health advantages without spikes in blood glucose levels.

This article was originally published on : theconversation.com
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Health and Wellness

Willow Smith’s debut collection with Moncler is now available – Essence

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Moncler

Willow Smith’s debut collection with Moncler has been launched. The capsule is a mixture of the inside of a musician, actress, writer and creator. In it, a futuristic and unbelievable world is explored through clothes. Smith’s personal style was also showcased. The lineup was originally revealed in Shanghai.

Willow Smith's debut collection with Moncler is now available
Moncler

“Minimalism and utilitarianism. Femininity and masculinity. Black and white. “Putting ideas together in an elegant way is something that really excites me and I wanted to explore that with this collection,” Willow shared.

“Willow’s magnetic energy is captured in a series of images exploring the primary themes of the collection: clashing contrasts, rebirth and renewal, yin and yang, recent beginnings – inspired by Moncler’s mountain origins and love of nature. “Willow’s creativity influences every aspect of the videos and photos accompanying the collection: she not only drives the concept, but also models her designs, narrates the short film and provides the soundtrack,” the brand said in a press release. The launch is accompanied by black and white campaign photos – the dramatization of those photos ushers in an exciting era for Smith.

Willow Smith's debut collection with Moncler is now available
Moncler

The collection is dominated by knitwear perfect for layering, a down jacket and heavy sweatshirts created in shrunken proportions. The capsule is accomplished with extensive outerwear options and a brief-sleeved T-shirt with silver eyelet. The T-shirt is also available in an extended-sleeved version. The collection includes cream and black shades. The down vest with a hood and a brief cut stands out.

Salix leather boots are characterised by an interesting design. In addition to nodding to punk influences, this footwear option is designed with a Moncler logo on the toe, elastic panels on the front and a rubber sole.

Willow Smith's debut collection with Moncler is now available
Moncler

“I am incredibly passionate about the outdoors and exploring this wonderful land. I imagine these pieces can easily transition from overnight camping to fashionable evening wear,” Willow added, emphasizing the natural duality of the collection.

Moncler X Willow Smith is currently available in chosen Moncler stores and more moncler.com .

This article was originally published on : www.essence.com
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