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Diabetes Drug May Reduce Dementia Risk, Study Shows – Here’s How the Two Diseases May Be Linked

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A recently published Korean study suggests that individuals with type 2 diabetes who’re prescribed a particular class of medication could also be in significantly worse shape lower risk of dementia.

Researchers compared the health outcomes of greater than 110,000 people aged 40 to 69 with type 2 diabetes who were prescribed a drug called SGLT-2 inhibitors with those of one other 110,000 patients taking a distinct class of medication, DPP-4 inhibitors. They followed the participants for a mean of 670 days.

The researchers found that after adjusting for potential confounding aspects, people taking SGLT-2 inhibitors had a 35% lower risk of developing dementia.

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Diabetes is taken into account to be risk factor for dementia. So it’s not entirely surprising that treating diabetes can reduce the risk of dementia. But why would one drug reduce the risk greater than one other? And how are diabetes and dementia even related?

Diabetes and dementia

Insulin is a hormone produced by the pancreas. Its job is to move glucose (sugar) from the bloodstream into cells, where it serves as an energy source. Type 2 diabetes occurs when the pancreas fails to supply adequate amounts of insulin, otherwise our cells will develop insulin resistance.

Dementia is attributable to changes in the brain and includes: several conditions which affect memory, considering, mood and our ability to perform on a regular basis tasks.

Diabetes has long been recognized as a risk factor for each Alzheimer’s disease and vascular dementiatwo most typical types of dementia. Both are characterised by a decline in cognitive function attributable to disease of the blood vessels in the brain.

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We don’t fully understand why diabetes and dementia are linked in this fashion, but there are some clues that will explain it. several possible reasons.

For example, diabetes increases the risk of heart disease and stroke, which damage the heart and blood vessels. When blood vessels in the brain are damaged, it could possibly contribute to cognitive decline.

Additionally, high blood sugar levels cause inflammation, which may damage brain cells and contribute to the development of dementia.

Dementia is attributable to changes in the brain.
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Treating diabetes will help reduce the increased risk

Better blood sugar control in individuals with diabetes helps protect blood vessels and reduces inflammation in the brain.

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Diabetes can initially be controlled with lifestyle changes similar to weight loss program and exercise, but treatment may include medications, similar to those taken by the study participants. Korean Studies.

Patients taking each varieties of drugs had comparable control of their blood glucose levels. But why did one reduce the risk of developing dementia compared with the other?

SGLT-2 (sodium glucose transport protein 2) inhibitors lower blood glucose levels by increasing the removal of glucose by the kidneys. These drugs are known to have positive effects also in other facets of health, including improving blood pressure, supporting weight reduction, and reducing inflammation and oxidative stress (a sort of damage to our cells).

Obesity AND hypertension themselves are risk aspects for vascular dementia and Alzheimer’s dementia, so it could be that these effects of SGLT-2 inhibitors reduce the risk of dementia to a greater extent than can be expected based on higher blood glucose control alone.

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Prevention vs. Cure

It is significant to emphasise that the good thing about a drug reducing the risk of developing a disease is totally separate from any suggestion that the drug may be useful in treating the disease. The best method to reduce the risk of lung cancer, for instance, is to give up smoking. However, once you could have lung cancer, quitting smoking just isn’t enough to cure it.

That said, due to the evidence linking diabetes and dementia, some diabetes medications have been previously studied as treatments for Alzheimer’s disease. And they’ve been shown to supply a point of profit for knowledge.

A nurse tests a patient's blood glucose level by pricking their finger.
People with diabetes often must take medications to manage their blood sugar levels.
Dragana Gordic/Shutterstock

Semaglutide, higher known by its trade name Ozempic, belongs to a different class of diabetes drugs (called GLP1 receptor agonists). Semaglutide is currently being studied as a treatment for early Alzheimer’s disease in two clinical trials involving over 3500 patients.

These studies were inspired by observations made during clinical trials of semaglutide in individuals with diabetes, which showed lower rates of dementia in people taking the drug in comparison with those taking a placebo.

Like SGLT-2 drugs, GLP-1 class drugs are known to scale back encephalitisGLP-1 drugs also appear to scale back chemical reactions that result in the formation of an abnormal type of a protein called Tau, one among the pathological features of Alzheimer’s disease.

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What’s next?

As our knowledge of the mechanisms underlying Alzheimer’s disease and other types of dementia continues to expand, there will even be advances in treatments.

It is unlikely that a single drug is the answer to Alzheimer’s disease. Cancer treatment has advanced to the point where the use of “drug cocktails” or combination of medicationis already routine.

One possible future for these diabetes drugs is that we could see them as a part of a variety of therapies that combat the ravages of dementia or, even higher, help prevent it, even in people without diabetes. But we want more research before we get to that time.

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This article was originally published on : theconversation.com
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Health and Wellness

How drinking alcohol can affect your health

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With the brand new 12 months, dry January comes, and a brand new surgeon general consulting in the sphere of alcohol and cancer.

Moderate drinking It was once thought that it brought advantages to the center, but higher research methods threw cold water at it.

“Drinking less is a great way to be healthier,” said Dr. Timothy Naimi, who manages the Canadian Institute of Research on the use of drugs on the University of Victoria in British Columbia.

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On Friday, US surgeon general Dr. Vivek Murty He called for the update of the present warning label General for drinks containing alcohol to take note of the chance of cancer. His proposal would require confirmation by Congress.

What is the pity in drinking alcohol?

Drinking raises Risk of several sorts of cancerIn this colon, liver, breasts and lips and throat. Alcohol breaks down within the body right into a substance called aldehyde aldehyde, which can damage the cells and stop them from repair. This creates conditions of growing cancer.

Thousands of deaths within the USA per 12 months can be prevented If people followed government dietary guidelines, he said Naimi.

These guidelines advise men to limit themselves to 2 drinks or less a day, and girls to at least one drink or less a day. One drink is the equivalent of about 12 ounces of a can of beer, a 5-inch glass of wine or alcohol shot.

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According to Murthy’s advice, there are about 100,000 cases of alcohol cancer and about 20,000 deaths attributable to alcohol -related cancer per 12 months within the United States.

“When wondering if drinking, remember that less is better when it comes to the risk of cancer,” Murty wrote on Friday on the social media platform X.

What about moderate drinking?

This concept that moderate drinking brings health advantages from imperfect research comparing groups of individuals in line with how much they drink. This was often measured in some unspecified time in the future. And not one of the research randomly assigned people to drink or not, so that they couldn’t prove the cause and effect.

People who report moderately drinking have the next level of education, higher income and higher access to healthcare, said Naimi.

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“It turns out that when you adapt to these things, the benefits disappear,” he said.

Another problem: many of the research didn’t include younger people. Almost half of the dying people due to alcohol -related causes die before the age of fifty.

“If you study people who survived in middle -aged, did not stop drinking because of the problem and did not become heavy drinking, this is a very chosen group,” he said Naimi. “This creates a benefit for moderate drinkers, which is actually a statistical illusion.”

Other studies undermine the concept alcohol has advantages. These studies are compared by individuals with a gene variant, which makes drinking in people and not using a gene variant unpleasant. People with a variant often drink little or no or in no way. One of those studies People with a gene variant were found have a lower risk of heart disease – one other blow to the concept alcohol protects people from heart problems.

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25 small changes to which you can commit yourself for a healthier new year

What do the rules say?

The guidelines differ significantly depending on the country, but the general trend is to drink.

Great Britain, France, Denmark, the Netherlands and Australia have recently reviewed latest evidence and reduced the recommendations for alcohol consumption. Ireland would require alcohol warning labels from 2026.

“The scientific consensus has changed due to the overwhelming evidence combining alcohol with over 200 health conditions, including cancer, cardiovascular disease and injuries,” said Carina Ferreira-Borges, a regional alcohol advisor on the Regional Office of the Regional Health Organization in Europe.

Naimi sat on the advisory committee that desired to lower American recommendations for men One drink a day. This advice was considered and rejected when Federal recommendations He left in 2020.

“A simple message that has best supported the evidence is that if you drink, less is better when it comes to health,” Naimi said.

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This article was originally published on : thegrio.com
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Health and Wellness

Nicole Ward, Mother of the NFL Denzel Ward Supergows, about the importance of dealing with heart rate

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Nicole Ward, Mother of the NFL Denzel Ward Supergows, about the importance of dealing with heart rate

Recognize that they may learn their name and surname

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February is a month of heart health, which implies it is time to raise awareness about heart health. Nicole Ward, Mother of the NFL Denzel Ward Supergen Let them know your name (MTKYN) Foundation, inspired by a mission to forestall a deadly heart in communities throughout the country by ensuring essential education and heart health resources.

Named in honor of her deceased husband, Paul Ward, who died of sudden cardiac arrest, the Foundation had a tremendous influence, training over 35,000 people at CPR and AED (automated external defibrillator). Mtkyn provided the life of emergency resources, including practical CPR certificates and AED machines, local high schools, gyms and other public facilities in Ohio. Nicole also played a key role in creating and implementing characteristic social events, reminiscent of Cleveland All-Star Expo Fitness popping up in the park and fitness under the lights, which magnetize 1000’s a 12 months, promoting heart health.

As an impressive educator for health and well -being, Ward played a key role based on the House Bill 47 act, which is now signed. This account requires that each one private and non-private schools in Ohio have an AED and emergency readiness plan, and require staff and trainers to check resuscitation and AED. Her support through MTKYn and legislative efforts ensures that schools are higher prepared to answer heart crisis situations, protecting students and communities.

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In addition, as a member of the NFL Smart Heart Sports Coalition, he supports its efforts to enhance sudden cardiac arrest in youth throughout the country. Its influence on the community was recognized with quite a few honors, including the Health & Wellness Award from 100 black men from Greater Cleveland, a special congress recognition certificate and a motivated and reinforced Cleveland Black Girl Rock Award. She was also honored in Greater Heart & Stroke Ball American Heart Association, receiving the Live Fierce Stand for All Award, recognizing it as a catalyst for a healthier life for everybody.

In addition to working with MTKYN, WARD and her family, scholarship funds Paul G. Ward Jr. Memorial, yearly supporting the Bedford High School (Bedford, Ohio), a student of financial needs. He is a member of the Professional Footblage Players Mothers Association, Delta Sigma Theta Borority Incorporated and the Links organization. After early retirement with Cleveland Clinic in 2019, Nicole continued his property license, joining the Chestnut Hill Realty, and for over 20 years she has been an investor of real estate in the Cleveland region. Read our conversation with Ward below.

Essence: You wear many various hats. How do you prioritize self -care, while strengthening your loved ones and a wider community?

Nicole Ward: Own care is essential. I learned that she is the loss of my husband’s loss. You undergo you are feeling invincible and you’ll be able to do all of it, but should you don’t take care of yourself, there isn’t any way you’ll be able to take care of other people. Sometimes life has a technique to offer you a brand new perspective and a brand new take a look at how it’s best to approach life. I actually have a brand new appreciation for all times and I understand that I actually have to take care of myself to be there and present for everybody else. First, I attempt to deal with God. My faith is at all times the first. I actually have a routine that I do every morning, from prayer and reading the Bible and meditation, and attempting to make more conscious decisions about how I eat.

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Let’s talk about the tragedy that hit your loved ones. Can you share your experience with your experience and the way you possibly can all cope with and the way is your experience now as a widow?

My husband was my beloved in highschool. He was definitely interested by fitness and he was aware of the things he ate. If you checked out him, you’ll see him as someone you think about to be a health account. He was very influential in the community, and influenced those that contacted him. One day he went to the spin class, and after about 20 minutes from us, which they spread, I received a phone call on the phone and got here from his phone from his instructor. He fell from a spin bike and experienced a sudden heartbreak.

He didn’t do it at the ambulance. And so later, once I began to conduct research, trying to know what happened when he died of sudden cardiac arrest, which truthfully, I didn’t know what sudden cardiac arrest was, but then I came upon what it was. I also learned that his death may very well be prevented and it didn’t must be a death sentence.

However, to assist someone experience, you should take immediate motion reminiscent of CPR and using AED. This caused a mission for our foundation: armament of people with awareness about the importance of resuscitation at the moment and knowledge on tips on how to use AED.

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Do you’re thinking that your foundation would really like to encourage other people to consolidate their heritage? Because the name itself states that you just all need to be sure that heritage is crucial for the foundation’s mission.

Heritage could be very vital. So the name of the foundation is what my deceased husband told the boys once they grew up. Regardless of whether it was before they got here out on the pitch, a basketball court in the community, just dressing, going to highschool, he just told them, he met your name. And they knew that it meant that there was a difference in a positive way. As you mentioned, we predict it is certainly in line with the Health Health Foundation. As if we would have liked people to hurry up and make them know your name.

If your husband were here with you in the physical field and at one of the events that each one guests, what would you pay and say?

The very first thing that got here to my mind is that they permit them to know our name. We not only make us get to know our name, but persons are accelerating to also leave heritage and make the world know their names. We created a movement. We hope that we accept a really painful and tragic situation for us, which was very unexpected and use it in a positive way, teaching and sharing with other experiences that we have now passed through in the hope that they are usually not to undergo it alone.

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This article was originally published on : www.essence.com
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Health and Wellness

“Active recovery” after exercises is to improve performance – but does it really work?

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Imagine you will have just finished training. Your legs are like jelly, your lungs are burning and you simply want to fall on the couch.

But as an alternative you stand up and go for an brisk walk.

Although this will seem contrary to intuition, performing slight activity after intensive training – generally known as “Active recovery” – suggested to reduce pain and speed up recovery after exercise.

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But does it work or is it one other myth of fitness?

What is energetic recovery?

Active recovery simply describes the performance of some low -intensity physical activity after onerous effort.

This is widely achieved through low -intensity cardio, akin to walking or cycling, but it may also consist of low -intensity stretching and even body weight exercises, akin to squats and a throw.

The key thing is to ensure that that the intensity is light or moderate, without going to “energetic” range.

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Basically, for those who can have a conversation during exercise, you’re employed in light to moderate intensity.

Some individuals are considering a straightforward training session in “Days of rest” for a type of energetic recovery. However, this was not really examined. So we are going to give attention to a more traditional type of energetic recovery in this text, where it is performed right after the exercise.

What does energetic recovery do?

Active recovery helps accelerate wasteakin to Mleczan and Hydrogen, after exercise. These waste products are transferred from muscles to blood before it was broken and used for energy or just excreted.

It is believed that this is considered one of the ways during which it promotes recovery.

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In some cases, energetic recovery has been demonstrated Reduce muscle pain on the times after the exercise. This can lead to a faster return for peak performance In some physical capabilities, akin to the stroke height.

Active recovery may include stretching.
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But energetic recovery does not seem to reduce Inflammation after exercise. Although it may sound like a foul thing, it is not.

Inflammation after exercise can promote increases strength and efficiency after exercise. And so when it is reduced (say, using Ice baths after exercise) This may lead to smaller training improvements than one could see in a different way.

This implies that energetic recovery may be often used after an effort without risking the advantages of the fundamental exercise session.

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There is also opposite evidence

Not all research on energetic recovery is positive.

Just a few studies Show that this is not higher than simply lying on the couch when it comes to reducing muscle pain and improving efficiency after exercise.

In fact it is More research Sugging energetic recovery has no influence than studies showing that this has an impact.

Although there could also be several reasons, two stand out.

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First, the way in which during which energetic recovery is utilized in the research it differs how much. There is probably a sweet place by way of how long energetic recovery should last to maximize your advantages (more on this subject later).

Secondly, probably the advantages of energetic recovery are trivial to small ones. Therefore, they’ll not at all times be considered “significant” in scientific literature, despite the offer of doubtless significant advantages at the person level. In sports science, research often has small tests, which can make it difficult to see small effects.

But it seems that there aren’t any studies suggesting that energetic recovery is less effective than doing nothing, so within the worst case it definitely won’t cause any damage.

When is energetic recovery useful?

Active recovery seems useful for those who want to do many exercises very quickly. For example, for those who were within the tournament and had 10-20 minutes between games, fast energetic recovery could be higher than doing nothing.

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Active recovery It may also be a useful strategy If you would like to perform exercises again inside 24 hours after intensive activity.

For example, for those who are someone who practices sports and you will have to play games on days, performing energetic recovery with low intensity after each game will help reduce pain and improve performance in the next days.

Similarly, for those who train at an event akin to a marathon and you will have a training session the following day after a very long or intensive run, energetic recovery may be higher prepared for the following training session.

And vice versa, if you will have just graduated with low to moderate intensity, it is unlikely that energetic recovery will provide the identical advantages. And for those who get greater than 24 hours of rest between exercise sessions, energetic recovery is unlikely because it will probably be long enough on your body to be In any case, back back naturally.

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Women's football team on Earth rests.
Active recovery may be useful for individuals with sports obligations.
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How to best use energetic recovery

The excellent news is that you just haven’t got to get better much to see the profit.

AND Systematic review Looking on the effectiveness of energetic recovery in 26 studies was found that 6-10 minutes of exercise was a sweet place when it comes to improving recovery.

Interestingly, the intensity of the exercises didn’t seem to matter. If he was at the moment, it had a positive effect.

Therefore, it is sensible to facilitate energetic recovery (because why would you hinder it for those who haven’t got to

Do not expect, nevertheless, that energetic recovery shall be an entire game changer. Studies suggest that the advantages will probably be small at best.

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This article was originally published on : theconversation.com
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