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Diabetes Drug May Reduce Dementia Risk, Study Shows – Here’s How the Two Diseases May Be Linked

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A recently published Korean study suggests that individuals with type 2 diabetes who’re prescribed a particular class of medication could also be in significantly worse shape lower risk of dementia.

Researchers compared the health outcomes of greater than 110,000 people aged 40 to 69 with type 2 diabetes who were prescribed a drug called SGLT-2 inhibitors with those of one other 110,000 patients taking a distinct class of medication, DPP-4 inhibitors. They followed the participants for a mean of 670 days.

The researchers found that after adjusting for potential confounding aspects, people taking SGLT-2 inhibitors had a 35% lower risk of developing dementia.

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Diabetes is taken into account to be risk factor for dementia. So it’s not entirely surprising that treating diabetes can reduce the risk of dementia. But why would one drug reduce the risk greater than one other? And how are diabetes and dementia even related?

Diabetes and dementia

Insulin is a hormone produced by the pancreas. Its job is to move glucose (sugar) from the bloodstream into cells, where it serves as an energy source. Type 2 diabetes occurs when the pancreas fails to supply adequate amounts of insulin, otherwise our cells will develop insulin resistance.

Dementia is attributable to changes in the brain and includes: several conditions which affect memory, considering, mood and our ability to perform on a regular basis tasks.

Diabetes has long been recognized as a risk factor for each Alzheimer’s disease and vascular dementiatwo most typical types of dementia. Both are characterised by a decline in cognitive function attributable to disease of the blood vessels in the brain.

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We don’t fully understand why diabetes and dementia are linked in this fashion, but there are some clues that will explain it. several possible reasons.

For example, diabetes increases the risk of heart disease and stroke, which damage the heart and blood vessels. When blood vessels in the brain are damaged, it could possibly contribute to cognitive decline.

Additionally, high blood sugar levels cause inflammation, which may damage brain cells and contribute to the development of dementia.

Dementia is attributable to changes in the brain.
PeopleImages.com – Yuri A/Shutterstock

Treating diabetes will help reduce the increased risk

Better blood sugar control in individuals with diabetes helps protect blood vessels and reduces inflammation in the brain.

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Diabetes can initially be controlled with lifestyle changes similar to weight loss program and exercise, but treatment may include medications, similar to those taken by the study participants. Korean Studies.

Patients taking each varieties of drugs had comparable control of their blood glucose levels. But why did one reduce the risk of developing dementia compared with the other?

SGLT-2 (sodium glucose transport protein 2) inhibitors lower blood glucose levels by increasing the removal of glucose by the kidneys. These drugs are known to have positive effects also in other facets of health, including improving blood pressure, supporting weight reduction, and reducing inflammation and oxidative stress (a sort of damage to our cells).

Obesity AND hypertension themselves are risk aspects for vascular dementia and Alzheimer’s dementia, so it could be that these effects of SGLT-2 inhibitors reduce the risk of dementia to a greater extent than can be expected based on higher blood glucose control alone.

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Prevention vs. Cure

It is significant to emphasise that the good thing about a drug reducing the risk of developing a disease is totally separate from any suggestion that the drug may be useful in treating the disease. The best method to reduce the risk of lung cancer, for instance, is to give up smoking. However, once you could have lung cancer, quitting smoking just isn’t enough to cure it.

That said, due to the evidence linking diabetes and dementia, some diabetes medications have been previously studied as treatments for Alzheimer’s disease. And they’ve been shown to supply a point of profit for knowledge.

A nurse tests a patient's blood glucose level by pricking their finger.
People with diabetes often must take medications to manage their blood sugar levels.
Dragana Gordic/Shutterstock

Semaglutide, higher known by its trade name Ozempic, belongs to a different class of diabetes drugs (called GLP1 receptor agonists). Semaglutide is currently being studied as a treatment for early Alzheimer’s disease in two clinical trials involving over 3500 patients.

These studies were inspired by observations made during clinical trials of semaglutide in individuals with diabetes, which showed lower rates of dementia in people taking the drug in comparison with those taking a placebo.

Like SGLT-2 drugs, GLP-1 class drugs are known to scale back encephalitisGLP-1 drugs also appear to scale back chemical reactions that result in the formation of an abnormal type of a protein called Tau, one among the pathological features of Alzheimer’s disease.

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What’s next?

As our knowledge of the mechanisms underlying Alzheimer’s disease and other types of dementia continues to expand, there will even be advances in treatments.

It is unlikely that a single drug is the answer to Alzheimer’s disease. Cancer treatment has advanced to the point where the use of “drug cocktails” or combination of medicationis already routine.

One possible future for these diabetes drugs is that we could see them as a part of a variety of therapies that combat the ravages of dementia or, even higher, help prevent it, even in people without diabetes. But we want more research before we get to that time.

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This article was originally published on : theconversation.com
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Health and Wellness

Can psychedelics help you drink less alcohol? Our new study aims to find out

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Psychhedels reminiscent of LSD and psilocybina (Active ingredient in magical mushrooms) is gaining increasingly more attention in psychiatry. Research suggests They can offer therapeutic advantages in conditions reminiscent of depression, anxiety, obsessive and compulsive disorders, dietary disorders and addiction.

Our research team Study whether N, N-Dimetytryptamine (DMT)Quickly acting psychedelic, can help people reduce alcohol consumption.

Alcohol is most frequently Incorrectly used substance in Great Britainpartly since it is legal, widely available and deeply rooted in social culture. While many individuals can enjoy alcohol sparselyIN significant number Fight to control their drinking. For these people, Excessive alcohol consumption It can lead to serious physical, mental and social consequences.

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Traditional treatments don’t work for everybody, which is why we examine alternatives reminiscent of psychedelics, which may allow people to change their behavior in a single transformational experience.



DMT is Metabolized quickly within the body. When administered intravenousThe effects start almost immediately, often in a single to two minutes. However, these effects are short -lived, lasting only ten to 20 minutes.

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Despite the short duration of many users, they describe this experience as very deep. They often report live visions, complex patterns and feeling in one other reality. In some cases, experience leads to a whole change in how they think, feel and perceive the world. For many, this experience is deeply significant and transformational.

But what happens within the brain presently and the way can it affect long -term behavior, reminiscent of a discount in alcohol consumption?



Neuroplasticity and addiction

Our team He is especially all for how psychedelics reminiscent of DMT can help within the context of addiction. One theory is that psychedelics can temporarily increase neuroplasticityBrain ability to create new neural connections. This temporary reinforcement can open a window of flexibility, enabling some people more open to change.

For someone who got stuck in a heavy drinking cycle, this increased plasticity can help them break the old habits and develop healthier behavior. Basically, it might probably offer the brain Opportunity for “again” Sam and disturbing unhealthy patterns underlying addiction.

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https://www.youtube.com/watch?v=ys9fbb19ws0

We also deal with reward and brain motivation systems, which play a key role in addiction. These systems affect the behavior related to pleasure, including food, sex and alcohol.

In individuals with Alcohol consumption disorderThese systems turn out to be hypersensitive to alcohol guidelines, often on the expense of other satisfying experiences. Some early studies He suggests that psychedelics can help “reset” these paths. We test this theory to see if DMT can reduce alcohol consumption by re -calibrating the brain prize system.

To examine these possibilities, we designed a study with drinking heavy, who’re motivated to reduce alcohol consumption. Each participant undergoes a radical screening test to be sure that they’re suitable for testing, and all sessions are conducted in a highly controlled, clinical environment with doctors and experienced researchers supervising this process.

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The study includes three visits to our UCL laboratory. We use through the first and third visit Functional imaging of magnetic resonance imaging (FMRI) to measure brain activity and observe how different areas of the brain interact.

During scans, participants watch emotionally engaging movies that provide a more natural way of testing brain response compared to abstract tasks. This helps us assess how DMT can affect the brain function in real, emotionally charged situations.

During the second visit, the participants are randomly assigned to receive DMT, placebo or non -pryshedel medicine (D-CykLoserina Or Lisers). It is believed that these subszymical substances are believed Promote neuroplasticity Without inducing full psychedelic effects of DMT.

. The test is double blind – Neither participants nor scientists know which substance is run. This helps to eliminate bias and ensures that the outcomes are as reliable as possible.

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In addition, we measure changes in brain activity during infusion of the drug with electroencephalography (EEG). EEG tracks the brain electrical signals and may help us predict which participants will almost certainly use DMT.

Participants also perform various psychological assessments, including questionnaires and tasks that measure memory, attention, mood and decision making. These data will help us understand how changes in brain function can relate to changes in behavior related to drinking.

What can we hope to discover

We are still within the technique of collecting data, but we’re excited whether DMT can lead to a major reduction in alcohol consumption. As scientists, it’s crucial for us to remain objective and permit the evidence to conduct our conclusions. By maintaining a “blind” test, until all results can be found, we be sure that our arrangements are objective and reliable.

If DMT proves to be effective in helping people to reduce alcohol consumption, especially for many who struggled with other treatments, it might probably pave the best way to a new approach to addiction therapy. Even if the outcomes are ambiguous, they may proceed to provide precious insight into the potential role of psychedels within the treatment of addiction and open new possibilities of future research.

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https://www.youtube.com/watch?v=pkr-jvglkng

It is very important to emphasize that these research takes place in a protected, controlled environment. Psychhedels are strong substances, and their effects could be unpredictable, especially outside the clinical settings. They usually are not a “magic ball” and usually are not suitable for everybody. The controlled setting allows us to examine our effects, while minimizing the chance for participants.

Having said that, we imagine in psychhedels offer a special opportunity To higher understand the brain and its ability to change. By examining how transformational experiences can affect behavior, we hope to contribute to the event of simpler treatment of addiction and other mental health conditions.

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This article was originally published on : theconversation.com
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Health and Wellness

Tina Knowles reveals the diagnosis of breast cancer and reminds people not to “bend over mammograms”

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Tina Knowles reveals the diagnosis of breast cancer and reminds people not to

Ghettos

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Tina Knowles revealed that she was fighting breast cancer. The 71-year-old learned that she had cancer in stage 1 in July 2024. She learned about her diagnosis at a time when she launched the Cécred hair care line along with her daughter Beyoncé.

“It is important not to slow down to your mammograms,” she said during an interview with people. The creator also revealed that she missed mammography. Task group of American preventive services recommended That women aged 40 to 74, who’re exposed to the average risk of breast cancer, receive mammography every 2 years, but you may also get one yr.

“I forgot that I did not go to the test for two years before I thought I did it,” she said – “Because Covid came, they called me and canceled and said, we would call you when we started testing again. I just thought that I did it. So you can’t play with it.”

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Tina revealed a message about her meeting with breast cancer in her diary, which he published on April 22.

“I fought with whether I would share this journey [in the book] Because I’m very private. But I decided to share it because I think these are many lessons for other women – he says. “And I believe that as women sometimes we’re so busy and we’re so wrapped and running, but you’ve got to go to the test. Because if I did not get the test early, I mean, fascinated with what could occur to me.”

While the news of a loved one could be devastating, Knowles said that her daughters had a realistic response to listening to her diagnosis.

She said that Beyoncé “took it well, remaining positive, and I already felt her mind racing, focusing on this as a task with precision.” Tiny’s second child, Solange said: “Mom, we’ll deal with it.” Additionally, Kelly Rowland who’s close to the matriarch, and her niece Angie Beyinka was also at her side. “My girls have become my team,” she wrote in a newly published book.

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Fortunately, the dressmaker underwent surgery last yr to remove the tumor, and also obtained breast reduction.

“I’m great,” she said. “Without cancer and incredibly blessed that God let me find him early.”

Knowles wants women to remember about regular research – key detection is essential.

“I didn’t know that there was stage 0. I could catch it at stage 0 if I didn’t miss my mammogram,” she said.

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Mama Super Gwiazda also wants people to know you can undergo the difficult terror of health and proceed to go to the top: “I want to show people that you can go and continue to fly.”

Nowadays, the 71-year-old is doing and feels good.

“I’m healthier, I eat better, I lost weight,” she told people.

“I want to give people hope,” Knowles added. “What scares me now is not the best to use every day that I left in this life.”

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This article was originally published on : www.essence.com
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Health and Wellness

President of HBCU will submit a request for a donor of organs in graduation

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Livingstone College, organ Donation, kidney


President HBCU prays that a member of his school community may also help him find an organ donor.

Dr. Anthony J. Davis, president of Livingstone College, has been fighting kidney failure for almost two years. Since the diagnosis, Davis has undergone almost 10 hours of dialysis treatment at night, and was also juggling the duties of institutions. During the last ceremony of starting Livingstone, May 3 revealed his tragic request for a donor of organs.

“When the Lord is a blessing, the enemy begins to play”, he shared Graduate class, on.

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Davis stays involved in lifting the college and her body, despite his medical failures. He remains to be working on increasing registration and recruitment, remaining at the highest of his goals to lift Livingstone. His term also recorded a donation of two anonymous gifts price $ 10 million per school.

Describing his health journey, he also noticed that none of his members of the family was entitled to a match because of their different blood groups.

“I said, my children, what is happiness? They have a good mother’s appearance and her blood group,” he shared the group’s laughter.

His emotional speech also inspired graduates to beat obstacles that they might encounter in their lives. Davis also began the “Be my match” campaign to assist search. The “Be My Match” initiative encourages those in the HBCU Livcustone community and out of doors of it to get to know a living donor. Davis expressed the hope and faith that his public declaration concerning the need for a donor would cause his community to seek out a match.

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Blacks are disproportionately affected by kidney disease. According to the National Institute of Health, the 2023 annual report showed that this demographic group Accounts 30% of all individuals with final kidney disease (ESKD). Black are also 4 times more exposed to death because of their ECOD than their white counterparts, because of which their ability to seek out a match is more essential than ever.

Bearing in mind these numbers, Davis hopes that his network will strengthen this campaign to the masses to assist the educator and supporter of HBCu save his life. When he finished his powerful and key message, the category of 2025 and Davis hope that in the subsequent era of their lives with latest prosperity.

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This article was originally published on : www.blackenterprise.com
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