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What Are Puberty Blockers? What Are the Benefits and Risks for Transgender Children?

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Puberty blockers are drugs that stop the body from producing estrogen and testosterone. In the clinic, they’re called gonadotropin-releasing hormone agonists (GnRHa).

If teens take these medications during puberty, the physical changes related to puberty are prevented. If these medications are stopped, the physical changes return.

Puberty blockers were used since the starting of the 80s in the treatment of precocious puberty in young children.

Since the Nineteen Nineties.Puberty blockers have also been utilized in transgender adolescents to stop the unwanted development of male or female physical changes that occur during puberty.

What advantages do transgender teens receive?

Many transgender children describe the anxiety about the undesirable physical changes that may occur during puberty, especially as puberty approaches.

For presumed females at birth, these undesirable changes include breast development and early periods. For presumed males at birth, these undesirable changes may include the development of a deeper voice, an Adam’s apple, facial hair, and a masculine construct.

Many of those physical changes are irreversible and cause not only Gender dysphoria but additionally misgendering. This is when transgender persons are mistakenly assigned the gender they were assigned at birth. Misgendering generally is a significant and lifelong the source of suffering.

Some transgender people will seek surgery to handle these unwanted irreversible changes. This may include chest masculinization, facial feminization, voice changes, or Adam’s apple reduction.

For young transgender people and their families, the most blatant advantages of using puberty blockers are: avoid unwanted changes that occur with puberty. It can even reduce misgendering and prevent the need for future surgeries.

Puberty blocking drugs may reduce misgendering.
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Several studies have evaluated the potential advantages of puberty blockers. Systematic review 2024 studies have provided consistent evidence that they’re effective in inhibiting puberty.

The study, which the review authors described as highest quality significantly improved psychological outcomes. Puberty blockers reduced suicidal thoughts and actions in transgender adolescents compared with those that didn’t use treatment.

When must you start using puberty blockers?

Puberty blockers can only be began once puberty has began. The age at which this happens varies greatly between individuals. To avoid unwanted physical changes, puberty blockers should ideally be began in early or middle adolescence.

However, many transgender adolescents were began on puberty blockers at the end of puberty and even after it had ended.

IN EnglandFor example, at the least 12 months of treatment with puberty blockers was previously mandatory for any transgender teen under 18 who wanted access to estrogen or testosterone. As a result, many young people began using puberty blockers long after puberty had ended.

One potential problem with starting puberty blockers after early or mid-puberty is that unwanted physical changes have already occurred, so no further profit must be expected from this treatment.

The last systematic review of puberty blockers noted that while many studies found improvements in psychological well-being, others found no difference. One possible explanation is that none of those studies considered the stage of adolescence at which treatment began.

Especially, a more recent study conducted at Harvard University evaluation was restricted to puberty blocker treatment in early and middle adolescence. Treatment was found to be related to significant reductions in anxiety, depression, and suicidal ideation.

Risk of Puberty Blockers for Transgender Teens

Puberty blockers are generally well tolerated. However, like every medical intervention, they can even cause undesirable effectsThis includes decreased bone density and fertility, and changes in adult growth.

When they begin after early or middle puberty, they usually tend to cause menopause-like unwanted effects, corresponding to hot flashes. This is as a result of a decrease in sex hormone production.

The girl looks warmly at her father
Puberty blocking drugs are generally well tolerated but can have potential unwanted effects.
Alena Ozerova/Shutterstock

There are also potential long-term effects of puberty blockers which are still being researched.

The brain matures significantly during adolescence. However, it’s unclear what effect puberty blockers can have on cognitive development. While the use of puberty blockers in early adolescence has not shown influence cognitive functioning, research on transgender teenagers are in progress.

Where are the randomized controlled trials of puberty blockers?

Randomized controlled trials are widely considered the gold standard for testing the effectiveness of medical interventions.

To date, there have been no randomized controlled trials of puberty blockers in transgender teens, leading some to call the treatment experimental. However, carrying out such hormonal intervention trials in transgender youth is problematic because it might be unethical to withhold treatment for research purposes.

In pediatric care, data from randomized controlled trials are sometimes lacking. more broadlySimilar research gaps apply to the use of puberty blockers in early puberty.

However, the politicization of transgender youth has meant that the use of puberty blockers in transgender adolescents has been judged by a unique standard.

How are puberty blockers accessed in several clinical situations?

IN United KingdomPuberty blockers will now only be available available for transgender teens through the National Health Service (NHS) as a part of a research effort, following the recommendations of the Cass Review, which checked out gender identity services available to children and young people through the NHS.

One of the primary criticisms of the review was that it didn’t consider the likely harms of denying hormone therapy to transgender teenagers.

In Australia, health experts also caution against comparing our healthcare system to the NHS and indicate that a lot of the recommendations in the review are consistent with practices currently utilized in Australian specialist gender equality services.

Puberty blockers in Australia can be found to transgender adolescents as a part of a comprehensive, team-based approach to gender-affirming care. This emphasizes holistic, individualized care that takes under consideration the young person’s stage of puberty while balancing potential advantages and risks.

This article was originally published on : theconversation.com
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Health and Wellness

Herrana Addisu’s “River” Refers to Ethiopian Beauty Standards – Essence

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Courtesy of Kendall Bessent

What does visibility seem like? Growing up in Ethiopia, SheaMoisture Grant– Filmmaker and artist Herrana Addisu’s work is devoted to shedding light on women in conflict and wonder standards in her home country. This can also be the case in her latest film, supported by Tina Knowles. “[River is] “It’s a story that I’ve been writing in my head my whole life because it’s the foundation of my life and my livelihood as a child,” Addisu tells ESSENCE.

Herrana Addisu's 'River' Touches Ethiopian Beauty Standards

After winning the Blueprint Grant last August, SheaMoisture has taken on the role of a creative agency Chucha Studio to produce a movie that might bring to life a narrative that the black community could relate to. Focusing on culturally and politically sensitive topics—from access to water and education to ancestral lessons, forced marriages, and wonder standards—Adisu took the funds back to Ethiopia (to work with an area production house Dog Movies) tell her story.

“I wanted the film to have these complicated conversations that we don’t always have in this day and age,” she says. For example, Ethiopian stick-and-poke tattooing (often known as “Niksat”) is a typical tradition that runs through each of her pieces. “Growing up, I always thought it was beautiful,” she says. “But there’s a certain reluctance to do it, because a lot of women don’t feel like they’re consenting to have a permanent tattoo.”

Herrana Addisu's 'River' Touches Ethiopian Beauty Standards

Referencing cultural and traditional views of beauty, she cites spiritual icons of black hair within the church as a central theme. “Our old Bibles and paintings that I grew up seeing are of black angels and they have mini afros,” says Addisu, who placed them on the actors alongside cornrows, scarves and hairdos. “My blackness was so obvious to me that I wanted to show that in the film as well.”

Herrana Addisu's 'River' Touches Ethiopian Beauty Standards

But as an artist, she also embodies the sweetness she captures. After shooting in Ethiopia, Adisu returned to New York to take part in the series alongside .[Photographer] Kendall Bessant I had the concept to test my limits in doing this cone on my head,” she says. “It’s very easy to push those limits to a certain extent once you’re behind the lens after which in front of it.”

Herrana Addisu's 'River' Touches Ethiopian Beauty Standards

In one photo, she props her chin on a jewellery stand, her hair bouffant, and in one other, her curls are in front of a riverscape, alluding to the source of life within the film. “Water flows in the global South, especially in the rivers of Utopia, are very important not only in rural communities but also in urban ones,” she says.

But the river can also be a source of vulnerability for ladies, who’re exposed to violence, kidnapping and trafficking as they carry water. “I thought that was a powerful catalyst that brought the whole aspect of the film together.”

Herrana Addisu's 'River' Touches Ethiopian Beauty Standards


This article was originally published on : www.essence.com
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Health and Wellness

Why is pain so exhausting?

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One of essentially the most common feelings related to chronic pain is fatigue, which may grow to be overwhelming. People with chronic pain may report feeling lacking in energy and motivation to interact with others or the world around them.

In fact, a UK study of individuals with chronic health problems found that pain and fatigue were the 2 biggest barriers for an energetic and meaningful life.

But why is long-term pain so debilitating? One clue lies in the character of pain and its powerful influence on our thoughts and behaviors.

Short-term pain can protect you

Contemporary ways of fascinated by pain emphasize its protective properties—the way in which it grabs our attention and forces us to alter our behavior to be able to protect an element of our body.

Try this. Slowly pinch the skin. As you increase the pressure, you’ll notice that the feeling changes until it becomes painful. The pain is what keeps you from squeezing harder, right? It’s how pain protects us.

When we’re injured, tissue damage or inflammation makes our pain system more sensitive. This pain stops us from mechanically stressing the injured tissue while it heals. For example, the pain of a broken leg or a cut under the foot means we avoid walking on it.

The concept that “pain protects us and promotes healing” is one of the crucial vital things that folks with chronic pain tell us. they learned what helped them recuperate.

However, long-term pain can overprotect you

In the short term, pain serves an especially effective protective function, and the longer our pain system is energetic, the more protection it provides.

But persistent pain may also help us prevent recovery. People affected by pain call it “hypersensitivity of the pain system”. Think of your pain system as being on alert. And that is where exhaustion is available in.

When pain becomes an on a regular basis experience, triggered or reinforced by an ever-widening range of activities, contexts, and cues, it becomes a relentless drain on resources. Living with pain requires significant and sustained effort, and this makes us drained.

About 80% of us are lucky enough to not know what it’s wish to be in pain, day in and day trip, for months or years. But take a moment to assume what it’s like.

Imagine having to pay attention hard, gather energy, and use distraction techniques to finish on a regular basis activities, let alone work, caregiving, or other responsibilities.

Whenever you’re feeling pain, you’re faced with a selection of whether and tips on how to act. Continually making that selection requires thought, effort, and strategy.

Mentioning your pain or explaining its impact on every moment, task, or activity is also tiring and difficult to speak when nobody else sees or feels your pain. For those listening, it could grow to be tedious, exhausting, or distressing.

The concentration, energy gathering, and distraction techniques required could make on a regular basis life exhausting.
PRPicturesProduction/Shutterstock

No wonder the pain is exhausting

In chronic pain, it’s not only the pain system that’s on alert. Increased inflammation throughout the body (immune system on alert), impaired production of the hormone cortisol (endocrine system on alert), and stiff and cautious movements (motor system on alert) are also hand in hand with chronic pain.

Each of those contributes to fatigue and exhaustion. So learning to administer and resolve chronic pain often involves learning tips on how to best manage the overactivation of those systems.

Losing sleep is also factor each in fatigue and pain. Pain causes sleep disruption, and sleep loss contributes to pain.

In other words, chronic pain is rarely “just” pain. It’s no wonder that long-term pain can grow to be overwhelming and debilitating.

What actually works?

People who are suffering from chronic pain include: stigmatized, rejected AND misunderstoodwhich may result in them not getting the care they need. Ongoing pain can prevent people from working, limit their social contacts and affect their relationships. This can result in a downward spiral of social, personal and economic drawback.

That’s why we want higher access to evidence-based care and high-quality education for individuals with chronic pain.

There is excellent news, nevertheless. Modern chronic pain care, which is based on first gaining a contemporary understanding of the biology underlying chronic pain, it helps.

The key appears to be recognizing and accepting that a hypersensitive pain system plays a key role in chronic pain. This makes a fast fix highly unlikely, but a program of gradual change—perhaps over months and even years—holds promise.

Understanding how pain works, how chronic pain becomes overprotective, how our brain and body adapt to training, after which learning recent skills and techniques to steadily rewire each the brain and body offers hope based on science; there is a powerful supporting evidence With clinical trials.

Any support is helpful

The best treatments for chronic pain require effort, patience, persistence, courage, and infrequently a very good coach. All of this is a fairly overwhelming proposition for somebody who is already exhausted.

So in the event you are among the many 80% of the population that doesn’t suffer from chronic pain, take into consideration what is needed and support your colleague, friend, partner, child or parent on this journey.


This article was originally published on : theconversation.com
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Health and Wellness

More than half of party drug users take ADHD medication without a prescription, new study finds

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Each 12 months, the National Drug and Alcohol Research Centre on the University of New South Wales in Sydney surveys a whole bunch of regular drug users in Australia to seek out out understand trends within the use of psychoactive substances throughout the country.

Today we published Report 2024during which 740 people from Australian capital cities who usually use ecstasy or other illegal stimulants were surveyed.

While the first focus of our research is illicit drugs and markets, we also monitor trends within the over-the-counter use of pharmaceutical stimulants, resembling ADHD medications.

This 12 months, 54% of people we spoke to had used pharmaceutical stimulants previously six months after they weren’t prescribed them, the best percentage now we have seen since we began asking people about this kind of drug use in 2007.

What are pharmaceutical stimulants?

Pharmaceutical stimulants include the drug methylphenidate (trade names Concerta and Ritalin), in addition to dexamfetamine and lisdexamfetamine (Vyvanse).

These medications are commonly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsya chronic neurological disorder that causes excessive sleepiness and sudden sleep attacks through the day.

These drugs work in other ways depending on the kind. However, they treat ADHD by increasing levels of necessary chemicals (neurotransmitters) within the brain, including dopamine and norepinephrine.

However, as with many pharmaceutical substances, people also use these stimulants after they should not prescribed. There is range of reasons someone may select to make use of these medications without a prescription.

Tests University students have shown that these substances are sometimes used to extend alertness, concentration and memory. Studies conducted amongst wider populations have shown that they may also be used experimentor to get high.

All over the world, including in Australiawere significant increases within the prescription of ADHD medications lately, likely on account of increased identification and diagnosis of ADHD. As prescriptions increase, the danger of these substances being diverted to illegal drug markets increases.

Some people may seek pharmaceutical stimulants to extend alertness and concentration.
Ground Photo/Shutterstock

What we found

The percentage of people using stimulants without a prescription has tripled since monitoring began – from 17% of respondents in 2007 to 54% in 2024. It has remained at a similar level lately (52% in 2022 and 47% in 2023).

Frequency of use remained relatively low. Respondents typically reported using non-prescribed pharmaceutical stimulants monthly or less continuously.

In this study, participants most continuously reported using dexamfetamine, followed by methylphenidate and lisdexamfetamine. Most (79%) said it was “easy” or “very easy” to acquire these substances, just like 2022 and 2023.

Of course, provided that our study focused on regular drug users, the over-the-counter use of pharmaceutical stimulants doesn’t reflect their use in the final population.

In 2022–2023 National Household Drug Strategy Surveygeneral population survey of Australians aged 14 years and over, 2.1% of the population (comparable to about 400,000 people) reported using pharmaceutical stimulants for non-medical purposes within the previous 12 months. This was just like the proportion of people reporting using ecstasy.

What are the risks?

Pharmaceutical stimulants are considered to have a relatively secure toxicity profile. However, like all stimulants, these substances increase activity sympathetic nervous systemwhich controls various functions within the body during times of stress. This in turn increases heart rate, blood pressure and respiration rate.

These changes may cause acute cardiac events (resembling arrhythmias or irregular heartbeats) and, with repeated use of high doses, chronic changes in heart work.

Recent Australian research has documented increase in poisoning involving these substances, although a significant proportion of these seem like intentional poisonings. In the poisonings that involved only pharmaceutical stimulants, the drugs were mostly taken orally, with the median dose being more than ten times the everyday prescribed dose. The commonest symptoms were hypertension (hypertension), tachycardia (fast heart rate), and agitation.

In our study, individuals who took pharmaceutical stimulants most frequently took them in pill form, taking a dose barely higher than that typically prescribed.

However, about one in 4 people reported snorting as a route of administration. This can lead to physical harm, resembling damage to the sinuses, and will increase the potential risks of the drug because it will possibly come into effect faster within the body.

A hand holds a bag of white powder.
Snorting stimulants could also be more dangerous.
Author: DedMityay/Shutterstock

Some pharmaceutical stimulants are “long-acting,” released into the body throughout the day. So there may additionally be a risk of premature re-dosing if people unknowingly use these preparations more than once a day. That is, if people don’t experience desired effects They may take one other dose on the expected time, which can increase the danger of uncomfortable side effects.

Finally, non-prescribed stimulants can have negative effects when taken with other medications. This can include a “masking effect” (for instance, a stimulant may mask the symptoms alcohol poisoning).

So what should we do?

Pharmaceutical stimulants are necessary medications within the treatment of ADHD and narcolepsy, and when used as directed, they’re relatively secure. However, there are additional risks when people use these substances without a prescription.

Harm reduction campaigns that highlight these risks, including differences between formulations, will be useful. Ongoing monitoring, alongside more in-depth investigation of associated harms, can also be key.

This article was originally published on : theconversation.com
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