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Cancer during pregnancy is rare, but is becoming more common. Here’s what researchers think is behind the increase

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Former Alone Australia winner Gina Chick diagnosed from breast cancer just days after checking out she was pregnant. She describes in his last book her experience with chemotherapy and what got here after it.

Fortunately, cancers diagnosed during pregnancy and in the 12 months after delivery are rare. But such cases are becoming more and more common in parts With world, including Australia. Scientists aren’t entirely sure why.

Here’s what scientists know thus far and treatment options.

Gina Chick talks about life, loss and loneliness in Australia on ABC TV’s Australian Story.

How rare is this?

New South Wales test found that in 1994, for each 100,000 women giving birth, roughly 94 cancers were diagnosed during pregnancy or inside one 12 months of birth. In 2013, this number increased to around 163 per 100,000. Although these statistics are over a decade old, they’re the latest and most rigorous data available in Australia.

Swede from 2023 test pregnancies in the years 1973–2017 showed similar results.

Both studies found that a couple of quarter of pregnancy-related cancers are diagnosed before birth, with the rest diagnosed a 12 months after birth.

What variety of cancer are we talking about?

First in the UK comprehensive assessment cancer during pregnancy – a review of diagnoses from 2016–2020.

This study, the NSW study and others found that breast and skin cancer (often melanoma) are the most typical cancers related to pregnancy. In this group, there was also a high percentage of thyroid cancer, gynecological cancer (especially cervical and ovarian cancer) and blood cancer.

A UK study found that around 92% of cancers were recent diagnoses and around 82% had symptoms. The majority (81%) were treated with curative intent, and roughly 82% of pregnancies related to a cancer diagnosis resulted in a live birth.

However, 20% of the moms died before the end of the five-year study period. Gastrointestinal cancers were particularly concerning. They were characterised by the highest mortality rate of roughly 46% and were related to diagnosis at a more advanced stage of cancer.

This could also be because lots of the symptoms of gastrointestinal cancers, resembling abdominal pain, fatigue and acid reflux disorder, overlap with those of pregnancy. In other words, some cancer symptoms may be confused with pregnancy symptoms, “masking” or delaying the diagnosis of cancer.

Breast cancer is considered one of the most ceaselessly diagnosed cancers today.
Production “My Ocean” / Shutterstock

Why are there more and more such cases?

The big selection of cancers that occur during and after pregnancy suggest that there are various aspects involved.

In countries with high socioeconomic status, women have children later in life, and the biggest risk factor for a lot of cancers is age. However, the evidence that age is a serious risk factor for pregnancy-related cancers is inconclusive. This may explain some, but not all, cases.

Another factor could also be increasing usage prenatal genetic testing in early pregnancy. They analyze DNA from the mother’s blood to detect chromosomal abnormalities in the developing fetus. But these tests may also provide details about the mother’s chromosomes. This has led to the diagnosis of Hodgkin’s disease, breast and colorectal cancer in pregnant women without symptoms.

Estrogen and progesterone are two hormones essential for the growth and development of breast tissue and supporting other points of a healthy pregnancy. They may also contribute to cancer developmentespecially breast cancer. However, it is unclear whether this is related to the increase in pregnancy-related cancers.

Other cancers, resembling skin cancer, have been linked to environmental aspects resembling exposure to UV radiation. Of note, melanoma was the leading pregnancy cancer in the New South Wales study, reflecting the high rate of skin cancer in the local population. Other environmental aspects, resembling smoking and human papillomavirus, have been linked to cervical cancer. Again, we will not be sure whether such aspects are related to the increase in the incidence of pregnancy-related cancers.

Healthcare worker wearing gloves examining the back of a patient with moles
In a study in New South Wales, the most typical was skin cancer.
African Studio/Shutterstock

What happens after the diagnosis is made?

Pregnancy complicates the diagnosis of cancer because any potential treatment for the mother may jeopardize the health and viability of the fetus. So some points of treatment may require adjustment.

Surgery can often be performed in any trimester of pregnancy, depending on the location of the cancer.

Radiotherapy requires careful planning because the effects of radiation on the fetus rely upon the developmental stage at which radiation is administered to the body and on the dose.

Chemotherapy must be avoided in the first trimester of pregnancy on account of its potential toxic effects on the fetus. It can often be given in the second and third trimester of pregnancy. Chemotherapy must be avoided inside three weeks of birth to cut back the risk of bleeding and infection in the newborn, who might also have a weakened immune system consequently of chemotherapy.

More targeted immunotherapies are typically given to the mother after delivery. Depending on her treatment, she could also be advised to not breastfeed. This is because the medicine can pass from mother to baby through breast milk.

What’s happening to the children?

Reassuringly, data from New South Wales showed no increase in the rate of perinatal deaths given to moms with pregnancy-related cancer.

However, there have been more planned premature births. This is because women are offered induction of labor and/or cesarean section to make it easier for the mother to undergo cancer treatment while also reducing the risks of treatment for the unborn baby.

There was also the next percentage of babies born with low birth weight and low Apgar scores (indicators of a baby’s condition soon after birth), which were probably related to premature birth.

What do researchers need to know?

We have lots to study why pregnancy-related cancers are rising and what women diagnosed with this cancer can expect.

We also have to mix cancer and obstetrics data in national databases. This would allow us to find out which areas must be prioritized for further research, provide clinical guidelines for cancer screening during and after pregnancy, and help assess responses to screening programs or therapies in the future.

This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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