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A new study suggests that weight loss medications like Ozempic may help with knee pain. Here’s why there might be a link

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The drug semaglutide, commonly known by the brand names Ozempic or Wegovy, was originally developed to help people with type 2 diabetes control their blood sugar levels.

However, scientists have found that it may also help with other health problems. Clinical trials have shown that semaglutide may be effective weight lossand a whole bunch of hundreds of individuals around the globe use it for this purpose.

Evidence has also shown that the drug can help with treatment heart failure AND chronic kidney disease in people with obesity and sort 2 diabetes.

Now a study published within the journal New England Journal of Medicine suggested that semaglutide may improve knee pain in people with obesity and osteoarthritis. So what did this study show, and the way can semaglutide pain and osteoarthritis be linked?

Osteoarthritis and obesity

Osteoarthritis is a common joint disease affecting 2.1 million Australians. Most people with osteoarthritis experience pain and have difficulty performing on a regular basis activities comparable to walking. The knee is there mostly affected joint by osteoarthritis.

Being obese or obese is primary risk factor for osteoarthritis of the knee joint. The relationship between these two conditions is complex. It involves a combination of increased knee load, metabolic aspects comparable to high cholesterol and blood sugar levels and inflammation.

For example, elevated blood sugar levels increase the production of inflammatory molecules within the body, which may damage the cartilage within the knee and result in development of osteoarthritis.

Weight loss is strongly advisable to cut back pain associated with knee osteoarthritis in obese or obese people. International AND Australian guidelines They suggest that losing just 5% of your body weight may be helpful.

However, for many individuals, losing weight through food regimen and exercise alone can be difficult. One study from the UK found that people with obesity were lower than one in ten prone to lose 5% or more of their body weight every year.

Semaglutide has recently entered the market as a potential alternative path to weight loss. It comes from a class of medicine often called GLP-1 receptor agonists and works by increasing the sensation of fullness.

Semaglutide for osteoarthritis?

Justification for the above-mentioned recent research was that although we all know that weight loss improves the symptoms of knee osteoarthritis, the consequences of GLP-1 receptor agonists haven’t yet been studied. So researchers set out to know what effect semaglutide might have on knee osteoarthritis pain, in addition to the effect on body weight.

They randomly assigned 407 people with obesity and moderate osteoarthritis to certainly one of two groups. One group received semaglutide once a week, while the opposite group received a placebo. Both groups were treated for 68 weeks and received advice on food regimen and physical activity. At the top of the treatment phase, researchers measured changes in knee pain, knee function, and body weight.

As expected, people taking semaglutide lost more weight than those within the placebo group. People taking semaglutide lost a mean of about 13% of their body weight, while those taking a placebo lost a mean of about 3%. More than 70% of individuals within the semaglutide group lost at the least 10% of their body weight compared with just over 9% of individuals within the placebo group.

Knee osteoarthritis is essentially the most common variety of osteoarthritis.
Studio SKT/Shutterstock

The study found that semaglutide reduced knee pain significantly greater than placebo. Participants who took semaglutide reported an extra 14-point reduction in pain on a scale of 0–100 in comparison with the placebo group.

This is far greater than the reduction in pain for an additional patient recent research amongst people with obesity and knee osteoarthritis. This study examined the consequences of a food regimen and exercise program in comparison with an attention control (through which participants receive details about nutrition and physical activity). The results showed only a 3-point difference between the intervention group and the control group on the identical scale.

The degree of pain relief reported within the semaglutide trial can also be greater than that reported for commonly used painkillers comparable to anti-inflammatory agents, opioids AND antidepressants.

Semaglutide also improved knee function in comparison with placebo. For example, individuals who took semaglutide could walk about 42 meters further in a six-minute walk test than people taking a placebo.

How can semaglutide reduce knee pain?

It just isn’t entirely clear how semaglutide helps treat knee pain brought on by osteoarthritis. One explanation may be that when a person loses weight, there is less stress on the joints, which reduces pain.

However, recent research also suggests that semaglutide and other GLP-1 receptor agonists may have these effects anti-inflammatory properties and may even protect against cartilage wear and tear.

Although the outcomes of this new study are promising, it is just too early to think about semaglutide a “miracle drug” for knee osteoarthritis. And since this study was funded by the pharmaceutical company that produces semaglutide, it should be vital to conduct independent studies in the long run to verify the outcomes or not.

The study also used stringent criteria, excluding certain groups, comparable to people taking opioids for knee pain. One in seven Australians see their GP for knee osteoarthritis they were prescribed opioids. The majority of study participants were white (61%) and feminine (82%). This means the study may not fully reflect the typical person affected by knee osteoarthritis and obesity.

It must also be taken into consideration that semaglutide may cause a variety of unintended effects, including gastrointestinal symptoms and fatigue.

There is a few concern that semaglutide may reduce muscle mass AND bone densitythough we’re still learning more about it.

Moreover, access to it may be difficult.

I actually have osteoarthritis of the knee, what should I do?

Osteoarthritis is a disease brought on by many aspects and it’s important to treat it multi-faceted approach manage it. Weight loss is a very important element for people who find themselves obese or obese, but so are other elements of self-control. This may include physical activity, pacing strategies, and other positive lifestyle changes comparable to improved sleep, healthy eating, and so forth.

This article was originally published on : theconversation.com
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Health and Wellness

Car exhaust fumes can be linked to autism, a developmental disorder increasingly diagnosed in black children

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Autism, ASD, car exhaust, autism risks, autism in Black children, theGrio.com

New research has found that exposure to automotive exhaust fumes in utero or in the early stages of a child’s development may cause autism.

According to a study published Tuesday, November 12 in the journal Brain medicineexposure to nitric oxide (NO) – produced during fuel combustion – while pregnant or in the primary months of the mother’s life may pose a “significant risk” of developing autism spectrum disorder (ASD) in the kid.

“NO is a common air pollutant, produced mainly by vehicle emissions and the combustion of fossil and industrial fuels. Exposure to NO and its NO2 derivatives while pregnant and early childhood may disrupt normal brain development,” the study authors wrote.

The authors added that “the timing of exposure is key.”

According to the researchers, exposure to these pollutants while pregnant and early development “constitutes a significant risk of ASD because these periods are essential for brain development.”

The study also found that folks with a family history or genetic history of autism spectrum disorder may be at increased risk of developing the condition, affecting the best way individuals communicate, learn, interact and behave.

It’s not nearly automotive exhaust fumes. The study examined other air pollutants, including ozone, wonderful particles and other emissions, and located that every one of those toxins combined increased the danger of developing autism.

In particular, it listed benzene as a “volatile organic compound commonly found in vehicle exhaust, industrial processes and tobacco smoke” that, when combined with NO2, can also increase the danger of ASD.

Air pollutants may promote the event of ASD because they cause inflammation. Experiencing neuroinflammation brought on by exposure to NO over an prolonged time frame may “impact” brain activity related to social and cognitive functions which might be typically impaired by ASD.

“Exposure to air pollution during pregnancy may activate the mother’s immune system, leading to inflammation and abnormalities in fetal brain development,” the authors wrote, adding: “Elevated concentrations of inflammation-related cytokines in maternal serum in utero and early infants have been associated with their lives. with poorer neurodevelopmental outcomes.”

One sec nearly 40% of Americans live without healthy airautism disproportionately affects black and Latino children in the US. This condition can be on the rise in this country.

According to Centers for Disease Control and Prevention1 in 36 children were diagnosed with ASD – a rise from 1 in 44 just two years earlier. Predominantly, the condition still affects boys more often than girls, although this too has been established girls are frequently diagnosed with ASD later in life.

Holly Robinson Peete was

For generations, white children seemed to have the disease at higher rates than other children, but in recent years this risk has modified as more black and brown families gain access to quality health care and earlier diagnoses .

As increasingly black families select to live with an autistic member of the family, several organizations have emerged to help spread awareness, advocate and supply support. These organizations include The color of autismthat gives families with culturally competent support and care; Autism in blackwhich offers educational and counseling services to Black parents raising autistic children; and Black Autism Support Societywhich goals to fill gaps in support for the black community.


This article was originally published on : thegrio.com
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Health and Wellness

Perfect Imperfection of Wabi-Sabi Makeup – Essence

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Fairchild/Penske Media archive via Getty Images

Perfection is an addictive ideal of beauty that we have now all fallen victim to. This is clear in every thing from our drugs cabinets full of “anti-aging” skincare products to standardization Botox parties. What’s more, we even see it in horror movies (think: ) – revealing our insatiable desire to research and abandon perceived flaws.

This season, nonetheless, perfection is an outdated trend. Wabi-sabi— a Japanese worldview characterised by finding beauty in imperfection — is gaining popularity as a crucial antithesis to the fear of perfection. While aesthetic surgery is entering itsThe undetectable era” in response to the improvements of the watch, the makeup world is questioning whether beauty even exists in perfection.

“Don’t stress about imperfection. Embrace it. Relaxed, vibrant makeup feels more real and authentic” – MAC Senior National Artist Fatima Thomas says ESSENCE. “Things that are a little bit uneven, like a little blurry or a little bit uneven, can actually be quite visually pleasing.”

Below, Thomas explains the impact of Wabi-sabi beauty and her skilled techniques in achieving this look.

The rise of Wabi-sabi makeup

“A lot of people are taking a less stringent approach to makeup,” says Thomas. “When you worry less about having every line be perfect, every blend being perfect, you can actually enjoy applying and wearing makeup.” With beauty tricks like showering after punching to set the look with steam or sleeping in eyeliner for a soft grunge aesthetic, “Wabi-sabi allows for greater freedom and self-expression.”

Why now’s the proper time to adopt this mindset

“Do you really need to spend an extra 10 minutes to get your eyeliner perfect, or is it already good enough,” she asks. “After the pandemic and global inflation, people don’t want to stress about their makeup,” she continues, as TikTok’s viral “dopamine menu” trend turns beauty right into a form of therapy. “Wabi-sabi is about doing your best, and if it’s a little shaky, it’s okay.”

What does imperfect makeup appear like?

With airbrushes and editing apps distorting our view of achievable beauty: “I believe [imperfection] it is an opposition to digital filters and Photoshop,” he says. “It could be intentional or accidental, but it takes away the urge to rush and refine everything to look photoshopped.”

According to Thomas, the wabi-sabi approach relies more on philosophy than on any particular view. However, the important thing to imperfections is in nuances: “Do your makeup quickly and refrain from fixing minor imperfections.”

This article was originally published on : www.essence.com
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Health and Wellness

Companies that help insurance companies deny pre-authorization claims –

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Medicare, Melissa D. Hall


KFF survey found that roughly 6 in 10 insured adults have experienced problems while using their insurance. Issues include denied claims, network adequacy, pre-authorization delays and denials. As the investigation shows, this is just not a surprise. A hidden industry makes money by denying doctors’ payment requests, called prior authorizations.

According to a ProPublica investigation, one in every of the important thing participants on this scheme is Evernorth’s EviCore. A ProPublica investigation found that EviCore is owned by the big insurance company Cigna. The largest U.S. insurance companies employ EviCore and supply protection to 100 million consumers.

EviCore apparently uses a synthetic intelligence-supported algorithm that insurance industry insiders call “the shield.” The algorithm system will be customized, which ultimately results in more pre-authorization claim rejections.

What’s even weirder is that EviCore reportedly has some contracts that allow it to make more cash the more it cuts health care spending by insurance companies.

EviCore is just not alone. Another big player is Carelon Medical Benefits Management, a subsidiary of Elevance Health, formerly Anthem. Although the corporate has been accused in court of unlawfully denying legitimate insurance applications, it denies all allegations.

How companies respond

EviCore claims that the approval process ensures that the procedures are protected, obligatory and price-effective.

“We are improving the quality and safety of healthcare, and – by a happy coincidence – we are significantly reducing unnecessary costs,” said an EviCore doctor in the course of the company’s series of webinars.

But based on the investigation, EviCore’s approach is way more sinister than it suggests. EviCore reportedly guarantees a 3-to-1 return on investment, which implies your insurer can pay $3 less for medical care and other costs.

For some perspective, in 2021 in Arkansas, EviCore denied prior authorization requests almost 20% of the time. Medicare Advantage plans denied prior authorization requests about 7% of the time in 2022, based on a ProPublica evaluation of knowledge.

A Cigna spokesperson said on behalf of EviCore: “Simply put, EviCore uses the latest evidence-based medicine to ensure patients get the care they need and avoid services they don’t need.”

The spokesperson added that the corporate uses algorithms in some clinical programs “only to expedite the approval of appropriate care and reduce administrative burdens on healthcare providers.”


This article was originally published on : www.blackenterprise.com
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