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Scurvy is largely a historical disease, but there are signs it is making a comeback

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Scurvy is often considered a historical disease, evoking images of sailors on long sea voyages affected by a lack of fresh vegatables and fruits.

However, doctors in developed countries, including Australian doctors, have recently reported treating cases of scurvy reported their findings today within the diary BMJ Case Reports.

What is scurvy?

Scurvy is a disease brought on by a severe deficiency of vitamin C (ascorbic acid), which is mandatory for the production of collagen. This protein helps maintain the health of skin, blood vessels, bones and connective tissue.

Without enough vitamin C, the body cannot properly regenerate tissues, heal wounds or fight infections. This can result in a row symptoms including:

  • fatigue and weakness
  • swollen, bleeding gums or loose teeth
  • pain and tenderness in joints and muscles
  • bruises easily
  • dry, rough or discolored skin (reddish or purple spots brought on by bleeding under the skin)
  • cuts and wounds take longer to heal
  • anemia (lack of red blood cells resulting in further fatigue and weakness)
  • increased susceptibility to infections.

This has affected sailors up to now

There was scurvy common from the fifteenth to 18th centuries, when naval sailors and other explorers lived on rations or went for long periods without fresh food. You can have heard about a number of the milestones within the history of this disease:

  • within the years 1497-1499Vasco da Gama’s crew he suffered seriously from scurvy during an expedition to India, as a results of which a large a part of the crew died

  • from the sixteenth to the 18th centuryscurvy spread amongst European navies and explorers, affecting notable figures corresponding to Ferdinand Magellan and Sir Francis Drake. It was considered certainly one of the best threats to the health of sailors during long voyages

  • in 1747British naval surgeon James Lind He is believed to have conducted certainly one of the primary clinical trials to indicate that citrus fruits could prevent and treat scurvy. However, it took several a long time before his discoveries were widely implemented

  • in 1795the British Royal Navy officially adopted the practice of giving sailors lemon or lime juicedramatically reducing the variety of cases of scurvy.

Evidence of re-emergence of scurvy

In a latest case report, doctors from Western Australia reported treatment of a middle-aged man with this disease. In a separate case report, doctors in Canada reported treats a 65-year-old woman.

There is loads of vitamin C in our food, but some people still do not get enough of it.
Rebecca Kate/Pexels

Both patients had leg weakness and broken skin, although doctors didn’t initially consider scurvy. This was based on premise that there is a lot of vitamin C in our modern food, so deficiencies shouldn’t occur.

In each cases, treatment with high doses of vitamin C (1,000 mg day by day for no less than seven days) resulted in symptom relief and eventual complete recovery.

The authors of each case reports fear that untreated scurvy may result in inflammation of blood vessels (vasculitis) and potentially cause fatal bleeding.

Last yr, a large hospital in New South Wales undertook: chart reviewduring which patient records are reviewed to reply research questions.

Vitamin C deficiency has been found to be common. More than 50% of patients whose vitamin C levels were tested were either moderately deficient (29.9%) or severely deficient (24.5%). Deficiencies were more common in patients from rural areas and lower socioeconomic status.

Now they are doctors he insisted consider vitamin C deficiency and scurvy as a potential diagnosis and seek support from a dietitian.

Why might scurvy come back?

Obtaining and consuming nutritious foods that contain enough vitamin C is unfortunately a problem is still a problem for some people. Factors that increase the chance of vitamin C deficiency include:

  • bad weight loss plan. People on restricted diets – as a result of poverty, food insecurity or dietary decisions – might not be enough vitamin C. This also applies to individuals who rely heavily on processed, nutrient-poor foods relatively than fresh produce

  • food deserts. In areas where access to fresh, inexpensive vegatables and fruits is limited (often called food deserts), people can inadvertently suffer from vitamin C deficiency. In some parts of developing countries, corresponding to India, lack of access to fresh food is a problem considered a risk for scurvy

  • cost of living crisis. With more people is unable to pay for fresh producePeople who limit their fruit and vegetable intake may experience nutrient deficiencies, including scurvy

A couple buys peppers at the supermarket
Peppers are a good source of vitamin C, but they are not low-cost.
Pexels/Jack Sparrow
  • Weight loss procedures and medications. Restricted food intake as a result of weight reduction surgery or weight reduction medications may result in nutrient deficienciesas on this one case report of scurvy from Denmark

  • mental illnesses and eating disorders. Conditions corresponding to depression and anorexia nervosa can result in severely restrictive diets, increasing the chance of scurvy, e.g. case report as of 2020 in Canada

  • insulation. Older people, especially those living alone or in nursing homes, can have this difficulty preparing balanced meals with the suitable amount of vitamin C

  • specific diseases. People with digestive disorders, malabsorption disorders, or on restrictive medical diets (as a result of severe allergies or intolerances) may develop scurvy if: is unable to soak up or devour enough vitamin C.

How much vitamin C do we want?

Australian Dietary Guidelines recommend adults devour 45 mg of vitamin C (more if pregnant or breastfeeding) every day. This is about as much as you’ll find in half an orange or half a cup of strawberries.

When there is more vitamin C digested than required, the surplus is excreted from the body within the urine.

Symptoms of scurvy may appear inside a month of consuming lower than 10 mg of vitamin C day by day.

Eating foods wealthy in vitamin C – corresponding to oranges, strawberries, kiwi, plums, pineapple, mango, peppers, broccoli and Brussels sprouts – may improve symptoms inside a few weeks.

Vitamin C is also available as a complement if there are the explanation why your dietary intake could also be in danger. Typically, supplements contain 1000 mg per tablet, a recommended upper limit day by day intake of vitamin C is 2000 mg.

This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Health and Wellness

Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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