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how the rapid development of vaccines against Covid-19 prepares us for future pandemics

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Since the first report of Covid-19 in December 2019, greater than 775 million registered infections and greater than 7 million deaths from the disease. This is what makes COVID seventh deadliest pandemic in recorded history.

Factors akin to climate change, disruption of animal habitats, poverty and global travel mean we’re prone to see more pandemics in the future.

It is unattainable to predict exactly when the next pandemic will occur or what it’s going to be. However, experts around the world are working to arrange for this inevitable “Disease X.”

One of the cornerstones of preparing for the next pandemic is to be in the absolute best position to design and implement appropriate vaccine. To this end, scientists and researchers can learn rather a lot from the development of a Covid vaccine.

A glance back

After the discovery of SARS-CoV-2 (the virus that causes COVID), work on the vaccine progressed in a short time. IN February 2020 the first batch of vaccines (from Moderna) was accomplished and the first clinical trials were conducted began in March.

The first vaccine was Pfizer/BioNTech mRNA for approvalDecember 2, 2020 in the UK. Approvals of this and other vaccines, including shots developed by Moderna (one other mRNA vaccine) and Oxford/AstraZeneca (a viral vector vaccine), followed elsewhere shortly thereafter.

Previously the fastest vaccine developed took about 4 years (for mumps in the Sixties). If Covid-19 vaccines took so long, it will mean we’d only introduce them this yr.

Estimated 13.72 billion doses of Covid vaccine have already been administered, and over 70% of the world’s population has received a minimum of one dose.

The rapid development and commercialization of Covid-19 vaccines will likely be one of the biggest achievements in medical science in history. It also means we’re in a a lot better position to reply to emerging pathogens in the future.

New vaccine technology

Rather a lot of work has been preparing us for development for a few years Covid vaccines as fast as us. This included the development of recent platforms, akin to viral vector and mRNA vaccines, that might be rapidly adapted to recent pathogens.

While scientists were working on mRNA vaccines for many years before the virus pandemic, Covid shots from Pfizer/BioNTech and Moderna were the first mRNA vaccines approved for use in humans.

These vaccines work by instructing our bodies (the “m” in mRNA stands for messenger) to provide the SARS-CoV-2 spike proteins. These are proteins found on the surface of the virus that help it attach to our cells. This implies that once we come into contact with SARS-CoV-2, our immune system is able to react.

This technology will almost actually be used to guard against other diseasesand will potentially assist in a future pandemic.

In the meantime, scientists are working to further improve mRNA technology. For example, “self-amplifying RNA” has the potential to reinforce the immune response at lower doses compared to traditional mRNA.

mRNA vaccines train our bodies to provide the SARS-CoV-2 spike protein.
Kateryna Kon/Shutterstock

While our current Covid-19 vaccines are protected and really effective at protecting against severe disease, they usually are not perfect. We may never have the opportunity to create a “perfect” vaccine, but some additional properties we would prefer to see in future COVID vaccines include higher reduction in transmission, longer-lasting effects, and the need for less frequent updates as recent variants emerge.

Even now they’re multiple Covid vaccines in clinical trials. So let’s hope that Covid-19 vaccines that improve the effectiveness of initial vaccinations might be available relatively soon.

Other desirable features include the vaccines we will administer with alternative routes for needles. For Covid-19 and other diseases akin to influenza, we’re seeing significant progress locally and internationally in terms of vaccines that might be administered through skin patches, through the noseand even orally.

Some challenges

Developing Covid vaccines has been an enormous challenge, but for the most part it may well be considered successful. Studies have estimated Covid vaccines In the first yr alone, 14.4 million lives were saved in 185 countries.

However, the history of vaccination against Covid-19 has also been related to many other challenges and doubtless many failures.

First, vaccine distribution was not equitable. An evaluation of the initial implementation was suggested almost 80% eligible people in high-income countries have been vaccinated, compared with just over 10% in low-income countries.

Vaccine delivery there was an issue in lots of parts of the world, so expanding local capability to enable faster vaccine production and distribution might be necessary in the next pandemic.

Moreover, hostile events related to Covid-19 vaccines, akin to rare blood clots after administration of the AstraZeneca vaccine, have influenced perceptions of the vaccine’s safety. Although any serious hostile event is very important, these events were very rare.

However, these problems have exacerbated other challenges which might be hampering the vaccine rollout, including: spreading disinformation.

Disinformation stays an issue today and can likely proceed to be widespread as we face the next pandemic. Meeting this challenge requires understanding what stops people from getting vaccinated, then informing, educating, and eliminating misinformation about each vaccinations and the risks of the disease itself.

The essential goal should proceed to be to revive and construct trust in public health authorities. Trust in governments and health authorities has declined during the Covid-19 pandemic, and evidence shows that less trust is related to fewer vaccines.

A woman receives the vaccine.
The rollout of the Covid-19 vaccine has posed many challenges.
Yuganov Konstantin/Shutterstock

Current preparations

There is little doubt that our recent experience with Covid-19, particularly the rapid development of a number of protected and effective vaccines, has placed us in a greater position to face one other pandemic.

This didn’t occur by accident. Even before the discovery of the Covid-19 virus, many preparations were made to facilitate this. Organizations akin to the Coalition for Epidemic Preparedness Innovations (CEPI) have been supporting research to rapidly develop vaccines to reply to a brand new threat.

CEPI conducts an ongoing program aimed toward developing a vaccine against the recent threat, i.e. disease just 100 days. While Covid-19 vaccines have been an enormous achievement, work continues in the hope that next time we will develop a vaccine even faster.

This article was originally published on : theconversation.com
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Health and Wellness

Google Street View enables quick risk assessment for older New Zealanders

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Google Street View has quickly turn into a tool for individuals who wish to get a feel for a community, have a look at real estate – and sometimes prank a tech giant when his mapping automobile drives by. However, it also has the potential to stop falls and injuries in New Zealand urban environments.

Falls are a number one reason for injury and accidental death amongst older adults, but identifying the situation of outside hazards is laborious and time-consuming.

in ours recent researchwe now have created a tool using Google Street View to audit the places where people walk.

The aim of our recent tool – Fall-SAFE – is to discover hazards in New Zealand’s built environment and create a database for local authorities and community groups to grasp where and why an older person may fall.

Costly risk

Annually, one in three people over 65 years of age suffer injuries from falls. This number increases to 1 to 2 for people over 80 years of age.

Only in 2023 ACC received 236,985 recent claims within the case of falls in people over 60 years of age. Many of those falls resulted in serious injuries equivalent to broken hips, hospitalization, and even death.

It’s not only older people who find themselves at risk of falling – although they’re by far the most important group. Last yr, ACC paid out NZ$2.15 billion to cover falls claims.

The effects of falls go further than simply medical recovery. Older individuals who have fallen outdoors or who’re afraid of falling on account of the perceived risk could also be less willing to go for walks. Then they lose physical, mental and social advantages this sort of activity.

Google Street View is becoming increasingly popular. However, it will possibly even be used as a fall risk assessment tool on sidewalks and other outdoor areas.
Smith Collection/Getty Images

Environmental assessment

Using data from emergency services Hato Hone St Johnwe identified 2,117 falls between July 2016 and June 2018 in urban areas involving adults aged 65 years and older. Wellington was excluded because town uses a distinct ambulance service.

Auditors then used Google Street View to evaluate the locations of those falls and discover hazards within the built environment which will have contributed to them. These hazards included trip hazards, uneven footpaths, obstacles (equivalent to overgrown bushes), and slopes.

In their assessment, the auditors used the “drop-and-spin” method, during which they conducted a 360° audit of the autumn site. Google Maps photos were arranged to be as near the date of the accident as possible.

Drop-and-spin virtual audits are faster than physical audits, but just as reliable. Moreover, virtual drop-and-spin audits enable the assessment of enormous geographic areas that will be difficult to examine in person.

Understanding the streets of New Zealand

After examining various fall locations, we gained a greater understanding of where falls occurred and what hazards can have contributed to them.

Half of all falls occurred in residential locations (49.1%) and 1 / 4 occurred in industrial locations (22.4%). An extra 16.2% of falls occurred in ‘other’ locations (equivalent to rural or industrial areas).

In over 60% of fall sites, at the very least one trip hazard was on account of poorly maintained sidewalks. The most typical obstacles were manholes, plumbing covers or grates (71.5%), poles (65.4%), utility boxes (46.6%), and plant overhangs (39.5%). Other obstacles, equivalent to bus shelters, chairs and tables, and drains, were recorded in 64.5% of locations.

Three-quarters of falls occurred in places with flat or gentle slopes (76.3%). Only 15.5% of falls occurred on a moderate slope, while 8.2% occurred on a steep slope.

The majority (95.6%) of the autumn sites had normal curb height (ten centimeters). In several locations there have been no curbs (2.3%) or stormwater drainage (2%). In most autumn locations, streetlights were present either on one side of the road (including partial or only a few locations) (54%), or on each side (44%). In 0.9% of the facilities there have been no street lamps visible.

Of all of the locations we assessed, just below 6% had no obvious risk. This seems to point that external aspects were a contributing consider the overwhelming majority of falls – although without information from the one that fell, it’s difficult to say for sure.

Cheaper and faster option

The current approach to assessing the security of urban environments – sending people to physically inspect a pedestrian path to discover problems – may be time-consuming and expensive.

And there may be simply no money for this work. A number of suggestions, including: Hamilton AND Mastertonannounced significant cuts to New Zealand Transport Agency funding for maintaining and repairing footpaths and cycle paths.

Another concern is that assessors may not fully understand the experiences of older people in these locations. A risk to someone 65+ may not seem to be a risk to someone of their 30s or 40s.

Understanding the aspects that contribute to falls in older adults – equivalent to obstacles and trip hazards – allows city planners to deal with problems within the built environment.

Our free audit tool enables councils and support groups to have a look at their environments to grasp risks. In our study, we applied this method to places where we all know people have fallen, but this tool may be used to evaluate risk in any environment.

Investing effort and time now to deal with your fall risk early could prevent money – and lives – down the road.

This article was originally published on : theconversation.com
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Health and Wellness

Viral Videos of White Men Harassing a Black Teenager in a Florida Neighborhood, Sparking a Police Investigation – Essence

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Photos: @qweenie333 via TikTok

Series viral videos launched a local police investigation after a group of white men followed and harassed a black teenager as he walked through his neighborhood in Sarasota, Florida.

The teenager, who has not been publicly identified, went for a walk on Oct. 10 to confer with his girlfriend on his cellphone after Hurricane Milton left their area without power and limited cell service, in line with his mother, Whitney Portela. shared the recording on TikTok and Facebook.

@qweenie333

TikTok, I really want help. Here you see my child being racially profiled, followed by 4 grown men, all because he was walking in OUR neighborhood… I assume we seem like we do not belong in an upscale neighborhood, but here’s the short story: The morning after Hurricane Milton, my son desired to walk around area to confer with his girlfriend on the phone because we had no electricity so his service at home was bad. THIS was what he needed to cope with. Even after I told these men that he lives here, we are usually not satisfied together with his response and proceed to harass him. It wasn’t a minute-long argument. My son was followed for over 10 minutes to cope with this. I’m pleased he recorded every moment and grateful that my baby remains to be here. But I would like to know the way it feels OK. I don’t need to live in a community that doesn’t accept me and my children because of the colour of our skin.#blacktiktok #blacktiktokcommunity #blm #blackalivemateria #blacktiktok #helpme #it ​​is

♬ original sound – WhitneyDiana

As he walked, 4 white men from the identical neighborhood began following him and asking him unreasonable questions on where he lived. It was then that the teenager began recording himself because his mother said he felt unsafe. The disturbing videos have since gained over 4 million views.

“Of course he doesn’t live here,” one of the lads says I heard a saying in the background.

“You passed my house 4 times; I do not know you; I’ve never seen you before and also you keep walking past my house,” one other man tells the teenager.

– Do you reside here? – one other man asks.

“I’m part of the neighborhood,” the teenager replies.

“Do you reside here? You approached my wife,” accuses one of the lads.

“I don’t know what you’re talking about,” the teenager says. – And I believe I can walk around my neighborhood.

“Yes, if you live here,” one of the lads replies.

Portela stated that although the recordings only show snippets of the interaction, her son was observed for over ten minutes.

“I’m so happy he recorded every moment and I’m grateful my baby is still here,” Portela wrote on TikTok. “I don’t want to live in a community that doesn’t welcome me and my children because of the color of our skin.”

Another clip posted by Portela shows one of the lads harassing the teenager getting out of a white sedan, pulling something from the passenger seat after which attempting to attack the teenager before one other man stopped him and restrained him.

In one other video, the teenager stops to confer with a Sarasota County sheriff’s deputy. He points to the lads following him and asks the deputy if their actions might be considered harassment.” “They are angry because I am in such an area,” said the teenager.

The Sarasota County Sheriff’s Office confirmed the news Sarasota Herald-Tribune that she was aware of the video and stated: “Detectives have been assigned and are actively locating and interviewing witnesses. The Sheriff’s Office takes these matters seriously and will thoroughly investigate any allegations of criminal activity.”

Leaders of the Sarasota chapter of the NAACP are working with the family and law enforcement to discover the male suspects. “When I saw the video, it was deeply disturbing,” said Trevor Harvey, president of the Sarasota NAACP. “It is upsetting that in 2024 we’re still scuffling with these issues for young men of color. It’s heartbreaking that we will not even walk in our own neighborhood without being harassed by someone who thinks we do not belong because of the colour of our skin.

Harvey emphasized the broader implications of the incident: “This is a clear reflection of the current climate in our country. It’s disheartening that we still have to deal with these types of problems.”

He also expressed immediate concern after seeing the footage. “This video reminded me of Ahmaud Arbery and we certainly do not want a similar tragedy to occur in our community. These people must be held accountable,” Harvey added.


This article was originally published on : www.essence.com
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Health and Wellness

Serena Williams is “recovering but improving” after recent health scares

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For Serena Williams, health at all times comes first. This week, the previous tennis star revealed that a benign cyst forced her to miss the Glamor Women of the Year awards ceremony. In Video from TikTok published on October 15, Williams revealed that she recently had branchial cyst the dimensions of a “small grapefruit” faraway from her neck.

“In May, I discovered a lump on my neck. I immediately went to (the doctor), had an MRI and was told I (had) a branchial cyst. Have you ever heard of it?” Williams wrote within the caption of the post. “They said I didn’t have to remove it if I didn’t want to… but it kept growing.”

Showing footage from the hospital, Williams explained that she was initially “scared” by the cyst when she found it just a few months ago. After undergoing a series of tests and biopsies, Williams finally decided to remove the cyst, as advisable by her doctor, when she noticed it was growing rapidly.

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“I decided to do more tests, 3 tests and then one biopsy, everything was still negative, but the doctors advised me to have it removed as soon as possible because it was the size of a small grapefruit and could get infected or worse, leak,” she continued in signature.

“I applied for it, but they had to put in a drain because there was too much of it. But everything worked out,” he explains in the video. “I’m really happy that I was able to work with some great doctors. I’m a little scared here, but I’m excited to move on to the next steps of treatment.”

Shortly after leaving the hospital, Williams returned to one in all her favorite roles: mother. Shutting down TikTok, the recovering tennis legend showed up on the American Girl doll store along with her eldest daughter Olympia.

“Mom is hurting, but mom has to keep coming,” she said, admitting she desired to go home and “pass out.”

Although she was in a position to help her daughter and is recovering, Williams he tweeted about having to miss “so many things” just like the Glamor Women of the Year awards and Rafael Nadal’s retirement ceremony.

“I feel grateful and happy that everything worked out,” Williams concluded. “And above all, I am healthy.”


This article was originally published on : thegrio.com
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