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XEC is now in Australia. Here’s what we know about this hybrid variant of the SARS-CoV-2 virus

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In the nearly five years since the emergence of the Covid-19 virus, you would be forgiven for forgetting the number of latest variants we’ve seen. Some have had a greater impact than others, but documented by virologists hundreds.

The latest variant that is making headlines it’s called XEC. This omicron subvariant has been reported mainly in the northern hemisphere, but is now occurring detected in Australia too.

So what do we know about XEC?

Is Covid still relevant?

People are less more likely to test for Covid-19 and fewer more likely to report it. Enthusiasm for track the virus generally decreasing.

However, Australia continues to gather data and report Covid data. Although the number of cases is more likely to be much higher than documented (approx This 12 months already 275,000), we can still tell when we see significant waves in comparison with periods of lower activity.

Australia has recorded its latest peak in Covid-19 cases of the 12 months June 2024. Since then, the number of cases has been declining.

But SARS-CoV-2, the virus that causes Covid, is actually still around.

What variants are currently in circulation?

Main Covid variants currently circulating around the world are BA.2.86, JN.1, KP.2, KP.3 and XEC. They are all descendants of Omicron.

This is the first time the XEC variant has been detected in Italy in May 2024, the World Health Organization (WHO) described it as a variant “under monitoring”in September.

From the moment of detection XEC has spread to over 27 countries in Europe, North America and Asia. As of mid-September, the highest number of cases were found in countries equivalent to the United States, Germany, France, the United Kingdom and Denmark.

XEC is currently catching up 20% of cases in Germany, 12% in the UK AND in the USA about 6%..

The virus liable for Covid is still evolving.
Photo: Center for Aging Better/Pexels

Although XEC stays a minority variant worldwide, it appears to have a growth advantage over other circulating variants. We don’t know why yet, but reports suggest it might be possible spread more easily than other variants.

For this reason, it is predicted that XEC may turn into the dominant variant worldwide in the coming months.

How about Australia?

Latest Australian Respiratory Surveillance Report it has been noted that an increasing proportion of sequenced XECs has been observed recently.

In Australia, 329 SARS-CoV-2 sequences collected from August 26 to September 22 were uploaded to the website AusTrakkaAustralia’s National Genomics Surveillance Platform for Covid-19.

The most sequences (301 of 329, or 91.5%) are JN.1 sublines, including KP.2 (17 of 301) and KP.3 (236 of 301). The remaining 8.5% (28 of 329) were recombinants consisting of a number of omicron sublineages, including XEC.

Estimates based on data from GISAID, the international repository of viral sequences, suggest that XEC is catching up about 5% of cases in Australia or 16 of 314 samples were sequenced.

Queensland reported the highest rates over the last 30 days (8% or eight of 96 sequences), followed by South Australia (5% or five of 93), Victoria (5% or one of 20) and New South Wales (3% or two out of 71). WA recorded zero sequences out of 34. No data was available for other states and territories.

What do we know about XEC? What is a recombinant?

The XEC variant is believed to be the recombinant descendant of two previously identified omicron subvariants, KS.1.1 and KP.3.3. Recombinant variants arise when two different variants infect a number at the same time, allowing the viruses to swap genetic information. This results in the emergence of a brand new variant having features of each “parent” lines.

KS.1.1 belongs to a bunch commonly often called “FLiRT” variantswhile KP.3.3 is one of the “FLuQE” variants. Both of these groups of variants have contributed to the emergence of recent ones increase in the number of Covid infections throughout the world.

WHO naming conventions for brand new COVID variants, letter combos are sometimes used to designate latest variants, particularly those who arise from recombination events between existing lineages. “X” normally means: recombinant variant (equivalent to XBB), while the letters following it discover specific lineages.

So far, we know little about the features of XEC and the way it differs from other variants. However, there is no evidence to suggest that symptoms might be more severe than with earlier versions of the virus.

We only know what mutations this variant has. In the S gene encoding the spike protein, we find the T22N mutation (inherited from KS.1.1), in addition to Q493E (from KP.3.3) and others mutations
known to omicron pedigree.

Will vaccines still work well against XEC?

Latest monitoring data doesn’t show a big increase in the number of hospitalizations because of Covid-19. This suggests that current vaccines still provide effective protection against the severe effects of circulating variants.

As the virus continues to mutate, vaccine firms will proceed to accomplish that proceed to update your vaccines. Both Pfizer and Moderna have updated vaccines targeting the JN.1 variant, which is the parent strain of the FLiRT variants and due to this fact should protect against XEC.

However, Australia is I’m still waiting to seek out out which vaccines could also be made available to the public and when.

In the meantime, omicron-based vaccines equivalent to the current XBB.1.5 spikevax (Moderna) or COMIRNATY (Pfizer) vaccines are still more likely to provide good protection against XEC.

It’s hard to predict how XEC will behave in Australia once summer arrives. We will need more research to higher understand this variant because it spreads. However, provided that XEC was first detected in Europe during the northern hemisphere summer months, this suggests that XEC could also be well-suited to spread in warmer weather.

This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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