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What pathogen could cause the next pandemic? How scientists are preparing for “disease X”

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Before the Covid-19 pandemic, the World Health Organization (WHO) did made an inventory priority infectious diseases. They were considered to pose a threat to international public health, but were still needed research to enhance their surveillance and diagnosis. In 2018 “X disease”, which meant that a pathogen we had not previously observed could cause a pandemic.

While it’s one thing to acknowledge the limits of our knowledge of the microbial soup we live in, recent attention has turned to how we’d systematically approach future pandemic threats.

Former US Secretary of Defense Donald Rumsfeld famously talked about “known knowns” (things we all know that we all know), “known unknowns” (things we all know that we do not know), and “unknown unknowns” (things that we do not know that we do not know) .

While this may occasionally have been controversial in the original context of weapons of mass destruction, he asserts a technique to think how we are able to approach future pandemic threats.

Flu: ‘the known known’

Influenza is a largely known disease; Basically, we’ve a minor pandemic every winter with minor variations in the virus annually. However, more severe changes might also occur, leading to spread in populations with little pre-existing immunity. The last time we saw this was in the 2009 case swine flu pandemic.

But there’s much we do not understand about the aspects that drive flu virus mutations, how they interact with population-level immunity, and find out how to best predict transmission risk, severity and impact annually.

The current subtype of avian influenza H5N1 (“bird flu”) spread widely around the world. This led to death many thousands and thousands birds and spread to several species of mammals including cows in the United States and marine mammals in South America.

Human cases have been reported in individuals who have had close contact with infected animals, but fortunately there’s currently no sustained spread between humans.

Although detecting influenza in animals is a big task in a big country like Australia, it does exist on-site systems detecting and responding to bird flu in wild and production animals.

Scientists are always monitoring quite a lot of pathogens with pandemic potential.
Edward Jenner/Pexels

It is inevitable that there can be more flu pandemics in the future. But it is not all the time the one we worry about.

Attention has been focused on avian influenza since 1997, when the country experienced an avian flu epidemic Hong Kong caused severe disease in humans. But next pandemic in 2009 comes from pigs in central Mexico.

Coronaviruses: ‘the unknown known’

Although Rumsfeld didn’t discuss “unknown unknowns”, coronaviruses would fit into this category. We knew more about coronaviruses than most individuals thought before the Covid-19 pandemic.

We have had experience with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) causing large epidemics. Both are brought on by viruses closely related to SARS-CoV-2, the coronavirus that causes COVID disease. Although they could have disappeared from public awareness before the pandemic, coronaviruses were included in the 2015 list of infections WHO list diseases with pandemic potential.

Previous research on earlier coronaviruses has proven crucial in enabling the rapid development of vaccines against Covid-19. For example, the Oxford group’s initial work on MERS vaccine was key to the development of AstraZeneca’s Covid-19 vaccine.

Similarly, previous research on structure spike protein – a protein found on the surface of coronaviruses that permits them to connect to our cells – was helpful in the development of mRNA vaccines for Covid.

It seems likely that there can be further coronavirus pandemics in the future. And even in the event that they don’t occur on the scale of a pandemic, the effects could be significant. For example, when MERS spread in South Korea in 2015, it caused only 186 cases in two months, but the cost of controlling it was is estimated at $8 billion (A$11.6 billion).

Coronavirus statistics on screen.
COVID might be considered the “unknown known.”
Markus Spiske/Pexels

25 virus families: an approach to ‘known unknowns’

Attention now turned to the known unknowns. There are roughly 120 viruses 25 families known to cause disease in humans. Members of every virus family share common properties, and our immune systems reply to them in similar ways.

An example is flavivirus familythe most famous members of which are the yellow fever virus and the dengue virus. This family includes too several other vital viruses, akin to the Zika virus (which may cause congenital defects in case of infection of pregnant women) and West Nile virus (which causes encephalitisor encephalitis).

WHO epidemic plan goals to contemplate the threats posed by different classes of viruses and bacteria. It examines individual pathogens as examples from each category to systematically expand our knowledge.

The U.S. National Institute of Allergy and Infectious Diseases went a step further by making vaccines and therapies appear on the list prototypical pathogens from key virus families. The goal is to have the opportunity to adapt this data to recent vaccines and coverings in the event of a pandemic brought on by a closely related virus.

Pathogen X, “unknown unknowns”

There are also unknown unknowns, i.e. “X disease” – an unknown pathogen that will cause a serious global epidemic. To prepare for this, we must adopt recent types of surveillance, focusing especially on places where recent pathogens may emerge.

In recent years, there was an increasing recognition of the need for a broader view of health, going beyond fascinated with the health of humans, but in addition of animals and the environment. This concept is generally known as “One health” and takes under consideration issues akin to climate change, intensive agricultural practices, the exotic animal trade, increased human encroachment on wildlife habitats, changes in international travel and urbanization.

This has consequences not only where to look for recent infectious diseases, but in addition how we are able to reduce the risk of disease “spillover” from animals to humans. This may include targeted research animals and folks who work closely with animals. Currently, testing mainly focuses on known viruses, but recent technologies can look for yet unknown viruses in patients with symptoms consistent with recent infections.

We live in an enormous world of potential microbiological threats. While influenza and coronaviruses have a history of causing pandemics in the past, an extended list of latest pathogens can still cause epidemics with significant consequences.

Continued surveillance of latest pathogens, improving our understanding of vital virus families, and developing policies to cut back the risk of virus transmission can be vital to cut back the risk of future pandemics.

This article was originally published on : theconversation.com
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Health and Wellness

WATCH: Joshua Joseph What kind of America do we want to be? – Essence

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“; } }); // Drag and scroll functionality const playlistContainer = document.getElementById(‘playlist’); let isDown = false; let startY; let scrollTop; playlistContainer.addEventListener(‘mousedown’, (e) => { isDown = true; playlistContainer.classList.add(‘active’); startY = e.pageY – playlistContainer.offsetTop = playlistContainer.addEventListener(‘mouseleave’; playlistContainer.classList.remove(‘active’); playlistContainer.addEventListener(‘mouseup’, () => { isDown = false; playlistContainer.classList.remove(‘active’); }); mousemove’, (e) => { if (!isDown) return; e.preventDefault(); const y = e.pageY – playlistContainer.offsetTop; const walk = (y – startY) * 3; .scrollTop = scrollTop – walk; }); } } if (” !== ‘efoc24’) { // Check DoubleVerify Quality Targeting signals before rendering the player if ( ‘unknown’ !== typeof PQ ) { PQ.cmd. push(function() { // If DVQT signals are not available after 500 ms, render the player anyway. const timeout_id = setTimeout( jwPlayerRender, 500 ); // Get “Authentic Direct” signals. PQ.getTargeting({ signals: [‘abs’] }, function(error, targetingData) { clearTimeout(timeout_id); jwPlayerRender(error? undefined: targetingData); }); }); } else { jwPlayerRender(); } function jwPlayerRender( dvqt_signals=”” ) { let jw_ad_tag ​​= {“client”:”googima”,”adscheduleid”:”G7hR9pQ2″,”schedule”:[{“tag”:”https://pubads.g.doubleclick.net/gampad/ads?correlator=&iu=/21698916284/ess/VideoNews&env=vp&gdfp_req=1&output=vast&sz=400×300%7C640x480%7C1000x1%7C1920x1080&description_url=__page-url__&tfcd=0&npa=0&vpmute=1&vpa=auto&vad_type=linear&url=__page-url__&vpos=preroll&unviewed_position_start=1&v=SRYaJJB3&pmnd=0&pmxd=60000&ad_rule=1&cust_params=ttid%3DSRYaJJB3%26frnch%3D__item-franchise__%26environment%3Dproduction%26kwblock%3DAbb%2CCapOne%2CLincoln%2CUPS%2CVG%2CATTCric%2CDisney”,”offset”:”pre”},{“tag”:”https://vid.springserve.com/vast/670880?url=https://www.essence.com/news/watch-joshua-jospeh-what-type-of-america-do-we-want-to-be/h=450&w=800&cb=2033″,”offset”:”50%”}]”offers”:{“bidders”:[{“id”:”jw-video-SRYaJJB3″,”name”:”jwdemand”,”publisherId”:”evcxFIDZ”,”siteId”:”WT5iFegj”,”placementId”:”24399785″}]”settings”:{“disableConsentManagementOnNoCmp”:true,”mediationLayerAdServer”:”dfp”,”floorPriceCents”:200,”floorPriceCurrency”:”usd”,”buckets”:[{“increment”:0.1,”max”:30,”min”:0},{“increment”:0.5,”max”:50,”min”:30}]}}}; // Configure ad tag on the fly… let additional_params = {}; // Input DVQT signals. if ( dvqt_signals && dvqt_signals.ABS.length > 0 ) { additional_params.ABS = dvqt_signals.ABS.join(“,”); } // Create a string of additional_parameters. let extra_params_str=””; for (enter additional_parameters) { let value = additional_parameters[key]; additional_params_str += `${key}=${value}`; if ( key !== Object.keys( additional_params .pop() ) { additional_params_str += ‘&’; } } // Update ad tag cust_params (must be URL encoded). if ( Object.keys( additional_parameters ). length > 0 ) { let ad_schedule = jw_ad_tag.schedule; if ( ‘undefined’ !== ad schedule type ) { for (let i = 0; i < ad_schedule. length; i++) { let address_address = new URL(jw_ad_tag. schedule[i].label); let query_params = new URLSearchParams(ad_url.search); query_params.set("cust_params", query_params.get("cust_params") + `&${additional_params_str}`); ad_url.search = query_params.toString(); jw_ad_tag.schedule[i].tag = ad_url.toString(); } } } let playerId; if ("undefined" !== type jwplayerQueue) { playerId = 'jw-video-SRYaJJB3'; jwplayerQueue.push({ 'instanceId': 'playerInstance_SRYaJJB3', 'playerId': playerId, 'config': { pid: 't6KP9zcV', playlist: "https://cdn.jwplayer.com/v2/media/SRYaJJB3", autostart: !jw_ad_tag, repeat: true, mute: true, aspect ratio: "16:9", share: {sites: ["facebook", "twitter", "email", "linkedin"]}, cast: {}, float: {disibility: true}, autoPause: {viewability: true}, displaytitle: true, displaydescription: true, controls: true, related: {displayMode: 'shelfWidget'}, interactive: {} , ad: jw_ad_tag ​​​​} }); } // Load video. jQuery(window).trigger("jw:loadplayers"); function waitForJWPlayer(callback) { if (type jwplayer !== 'undefined') { callback(); } else { setTimeout(function() { waitForJWPlayer(callback); }, 500); } } waitForJWPlayer(function() { jwplayer(playerId).on('adsManager', function (adsManagerLoaded) { let adsManager = adsManagerLoaded.adsManager; let videoElement = document.getElementById(playerId ); let config = { anId: '929481' , campId: '640x360', ias_xps: "autoplay", // autoplay state ias_xbp: "2", // video destination type ias_xar: "1" // autoplay state } // Start IAS integration googleImaVansAdapter. init(google, adsmanager, videoitem, config } } });

This article was originally published on : www.essence.com
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Health and Wellness

Primary care involves more than primary care physicians. A new review shows how patients can gain better access to healthcare

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Today there are Australians more likely than previous generations suffered from complex and chronic diseases similar to diabetes, heart disease and depression.

This means they’re more likely to need health care from a wide range of providers, similar to nurses, podiatrists, psychologists and physiotherapists, in addition to general practitioners. This is named “multidisciplinary care”. It works best when the abilities of all these professions can be found to the patient in a coordinated way.

However, the role of the health professions and how they’re financed have been frozen in laws and policy for a long time. All changes are gradual and chaotic. This mainly involved adding more items to the Medicare schedule, with each specialist practicing individually.

The result was greater inequality of access. Because less than half Alliance visits are billed collectively, with most patients paying almost A$70 for every consultation, and sometimes much more. Those who cannot afford the out-of-pocket costs and can’t discover a bulk invoicing specialist are missing out.

To assess how the federal government can remove barriers to team-based care and ensure healthcare employees achieve their full potential or full ‘scope of practice’, the federal government commissioned an independent review last yr.

The final report published yesterday sets a new path for primary care employees. This will make multidisciplinary care accessible to all Australians.

Utilizing the total potential of healthcare employees

The review included extensive consultations, including on two issues papers. The report itself comprises feedback from the consultation, including skeptical comments reflecting differences of opinion.

The title of the report was reflected, Unlocking the potential of our healthcare employeesits primary focus is on changing the foundations and regulations imposed by state and federal governments. This makes the work of healthcare employees more difficult and limits their ability to use their full skills and knowledge to manage patient care.

Over the past a long time the education of health care employees has improved. Professionals are subsequently able to do more than before. However, rules and regulations haven’t progressed, making it difficult for professionals to share these skills and knowledge.

The review found that that is contributing to profession dissatisfaction and other people leaving a wide range of health professions, exacerbating workforce shortages.

The review proposes a new way of documenting and describing what a occupation can do, through a so-called national skills and capabilities framework and matrix.

As with many other recommendations, the review highlights where that is already getting used internationally and how it can be integrated into other policies and frameworks to help with implementation.

Health care employees don’t use all their skills.
Studio DC/Shutterstock

To the frustration of most allied health professions, the review doesn’t recommend greater Medicare payments to allow them to practice independently.

Rather, the review beneficial paying for general practices to develop multidisciplinary teams. This will help professionals collaborate moderately than compete or isolate themselves.

The review also beneficial changing the foundations on healthcare skilled referrals, allowing qualified healthcare professionals to refer directly to non-GP specialists in similar areas. This signifies that if mandatory, your psychologist can refer you directly to a psychiatrist, or your physiotherapist can refer you directly to an orthopedic surgeon, moderately than going back to your GP.

This will weaken the GP’s gatekeeper role and potentially undermine the more holistic care provided by GPs. However, from the patient’s viewpoint, eliminating the intermediate step saves him/her out-of-pocket expenses.

The necessary suggestion recognizes that the health care system is evolving and that policies and regulations must evolve as well. It is subsequently now complementing its recommendations for change by introducing a continuous review approach through an independent mechanism. This would supply evidence-based advice and proposals on:

  • significant workforce innovations
  • new roles in health care
  • workforce models that involve a major change in scope.

When will we see change?

The review outlined a loose implementation timeline that might be described as short, medium and long run. It also assigns responsibility for every element of its recommendations to the suitable authorities and governments.

As almost all the recommendations require legislative changes, and lots of of them require agreement between the Commonwealth and the states, it’s unlikely that any of the changes will come into force this financial yr.

The review beneficial making changes in a scientific, evidence-based and protected way. Implementation would begin in areas of best need, similar to rural and distant Australia, in addition to in practices most ready for change, similar to Aboriginal Controlled Community Health Organizations or Victoria Community Health Centres.

The man is waiting for the doctor
The review beneficial changes to the referral process.
Voronaman/Shutterstock

IN releasing Health Minister Mark Butler described it as a “landmark” report and noted the complexity of implementation, which might require joint motion with states and territories. He noted the necessity for further consultations, but nevertheless adopted a supportive tone.

Can this review speed up real health reform?

Overall, the review found a pleased medium between giving healthcare employees the liberty to act and the stringent and inappropriate rules and regulations that currently limit patient care. It also outlines practical steps to achieve your goals.

The only drawback of the report is the emphasis on harmonizing state and territorial approaches. This would replace the present approach under which each state and territory decides, for instance, which vaccines can be administered by which specialists and which pharmacists can dispense over-the-counter.

One of the advantages of a federation is the potential for state and territory innovation and cross-border learning. Harmonization will limit such experimentation and will lead to greater stagnation seen previously in medical expert policy.

This article was originally published on : theconversation.com
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Mamas at work: Abby Phillip on mom guilt and self-care as a political journalist

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Courtesy of CNN

As I speak to journalist and political correspondent Abby Phillip via Zoom, it’s a complicated time. Three weeks before the overall election, the political climate is grim and stuffed with increasingly inflammatory rhetoric. Phillip is knee-deep in all of it, as she just celebrated a yr as a primetime CNN anchor along with her fast-growing series .

He has been presenting his views on major news stories for the reason that starting of his show, starting two days after Hamas attacked Israel on October 7, 2023, pushing through the first elections and covering this yr’s White House race. and a fundamental change of candidates that was breathtaking to observe. “It was a big selection of things. It was fun and exciting. Honestly, I’m really proud that we’re in a position to have this reach,” she says.

Phillip needed to moderate heated discussions (weeks after our conversation, her show went viral due to conservative commentator Ryan Girdusky’s nasty comment about progressive commentator Mehdi Hasan). But she’s calm, cool and collected since the Harvard graduate believes within the importance of hearing all points of view.

“I mainly think we should listen to other points of view,” he says. “There are differences of opinion amongst individuals with the identical political views. There are differences of opinion amongst individuals with different political views. I believe it is important to listen to these people’s opinions. And for those who don’t, then this is not the appropriate program for you.

Mamas at work: Abby Phillip on mom guilt and self-care as a political journalist - 'If I absorbed it all, I'd go crazy'
CNN Digital Expansion 2015 Fareed Zakaria

“I think sometimes questioning what you think is important can strengthen your point of view. Maybe you will actually win the argument of ideas, or maybe you will lose the argument of ideas and hear something you didn’t even think about,” he adds. “I don’t have to get over this.” Hello there. Ignorance is just not bliss. You don’t profit from not knowing that other people have different points of view, because those people not only are on this country, but in addition they vote.”

Getting used to this discussion doesn’t suggest it’s going to be a piece of cake for Phillip. She, like many citizens on this country, is uninterested in the best way things are.

“Listen, it’s exhausting. I won’t lie,” he says. “There are definitely days when you come into the show and you’re like, why are we talking about this? Sometimes the issues that this political environment puts at the forefront are so disconnected from what is really important to real people. This is especially frustrating when it is based on lies and things that are not true. It’s exhausting.”

But what sets her aside from the remainder of us is that Phillip doesn’t hassle creating boundaries with regards to the news he consumes. She is just not a fan of getting information from social media or other sources that usually are not reliable.

“It’s my job, so I have to engage in politics, but I’ve also developed a very strong filter for the types of information I consume,” she says. “I think when you consume a lot of information that is designed to make you feel emotional, it will be emotionally exhausting. Sometimes there’s nothing wrong with that, but when you hit a wall, you just have to get the facts and be very diligent about it.”

Phillip finds respite and joy in watching light, sweet content on social media. “I’m here for pictures of your children. I’m here for fall adventures. I came here to take holiday photos,” she says. “I create handrails. If I ate it all, I would go crazy. I try to consume social media content that makes me smile, as opposed to content that makes me angry or sad. And this is how I create more balance in my life so that it doesn’t become so overwhelming. I really think you can care deeply about what’s happening to this country while also protecting your sense of sanity.”

However, exhaustion is normal, especially on Election Day. But because Phillip has covered previous elections as a political reporter, including 2020 and 2016, she knows the adrenaline and the ever-increasing vote count will keep her energized. But on daily basis, as a sleep-deprived mother of a 3-year-old daughter, like all moms, she tries her best to realize all of it. He goes to production within the evening when people get home from work, FaceTimes his daughter while she sleeps, and returns home for his evening ritual at 11:30 p.m.

Mamas at work: Abby Phillip on mom guilt and self-care as a political journalist - 'If I absorbed it all, I'd go crazy'
Courtesy of CNN

“It’s a juggling act, as it is for most parents. For me, most days don’t look the same. But I will say that most of my days revolve around finding little bits of time to spend with my daughter because my schedule is not a normal parenting schedule,” she says. “I feel like I’m working all day and she’s at school all day, but I actually go to the office when most people with regular schedules are eating dinner with their families. They went to bed and after school they caught up with their children. These are the hours I am in the office.”

She admits that sometimes she feels mommy guilt. She says she misses more things than she would love because she will be able to’t be as present as she would love to be from Monday to Friday. Still, she tries to be nice to herself.

“My daughter is beginning to feel a lot of emotions and is in a position to express them. That’s why he tells me how he feels,” says Phillip. “Honestly, I think it’s difficult. I mean, there’s no way to sugarcoat it. There are days that my daughter pushes me away because she is upset that I am not around. These are actually the hardest days because this kind of rejection is a reaction to him wanting you to be around him more. And then there are mornings like this morning when she cuddled up to me, usually she’s so happy to be going to school, but it was a three-day weekend so we spent a lot more time together. And this morning she didn’t want to go to school, and stopping was really, really hard. It’s hard for working moms because nothing can replace you as a mother.”

“I’m trying to give myself some grace. I do what I have to do and I take my job and everything that comes with it very seriously. But there are also times when I simply say, “I’m sorry, I can’t go to this event.” I can not figure it out. I can not do this because time spent with my child is the one thing that cannot be outsourced,” she adds. “You can’t give this job to anyone else. There is no substitute for you. So sometimes you have to say no to other things to make sure you put money in the piggy bank with your child at that time.”

He says it’s a constant give and take. As a working mother, who cannot relate to this?

“There are ups and downs, and sometimes you are feeling like you are not doing a good job of bouncing back. And other days it’s great,” he notes. “I hope, I pray, that at the end of all this, maybe when she grows up and is on her own, she will look back on this time and say, my mom was a great mom and I’m really proud of her for the work she did and all that. And that’s all we can count on as parents.”

Showing grace to yourself also is available in the shape of taking good care of yourself whenever you’re not performing live or directly in front of the camera. Phillip works hard to supply her with peace, including staying near home, baking, sometimes along with her daughter, creating flower arrangements and living a quiet, private life.

“I also try to find time to take care of myself physically because the stamina you need to be able to work full time, be a parent and have that energy is so high. – says. “Over time, I realized that when I exercised or did some physical activity, it gave me more energy. So I try to really invest in myself in this way.”

He also needs this energy to proceed to hide the chaotic nature of the federal government. But after a yr as an anchor, Phillip can not seem to decelerate with regards to keeping the general public informed in a unique, engaging and very possible way every night on cable news.

“I don’t think it’s helpful to stick your head in the sand about what other people in this country believe, and I think we should understand that. We should address this with all determination. And it may make you uncomfortable to hear it, but that’s American democracy,” he says. “We won’t have just one point of view on . That’s not how we do it. And I don’t regret it.”

This article was originally published on : www.essence.com
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