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What is type 1.5 diabetes? It’s a bit like type 1 diabetes and a bit like type 2 diabetes – but it’s often misdiagnosed

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While you are probably accustomed to type 1 and type 2 diabetes, you’ve got probably heard less about type 1.5 diabetes.

Type 1.5 diabetes, also often known as latent autoimmune diabetes in adults (LADA), is characterised by the next features: each type 1 and type 2 diabetes.

More people learned about this condition after Lance Basbest known for his role in the long-lasting American pop band NSYNC, recently revealed He has it.

So what is type 1.5 diabetes? And how is it diagnosed and treated?

There are several kinds of diabetes

Diabetes is a group of conditions that occur when the extent of glucose (sugar) within the blood is higher than normal. In fact, there are greater than ten types diabetes, but probably the most common They are type 1 and type 2.

Type 1 diabetes is autoimmune disease where the body’s immune system attacks and destroys the cells within the pancreas that produce the hormone insulin. This results in little or no or no insulin being produced.

Insulin is vital for transporting glucose from the blood into our cells where it could possibly be used as an energy source, which is why individuals with type 1 diabetes need it every day intake of insulin medication.Type 1 diabetes often it appears in children and young adults.

Type 2 diabetes is not an autoimmune disease. It occurs when the body’s cells grow to be immune to insulin over time, and the pancreas can not produce enough insulin to overcome this resistanceUnlike type 1 diabetes, individuals with type 2 diabetes still produce some insulin.

Type 2 is more common in adults, but more and more observed in children and adolescents. Management may contain behavioral changes resembling nutrition and physical activity, in addition to oral medications and insulin therapy.

People with diabetes might have to watch their blood sugar levels often.
Dragana Gordic/Shutterstock

How does type 1.5 diabetes differ from type 1 and 2 diabetes?

Like type 1 diabetes, type 1.5 diabetes occurs when the immune system attacks the cells within the pancreas that produce insulin. However, individuals with type 1.5 diabetes often don’t need insulin immediately because their condition progresses more slowly. Most individuals with type 1.5 diabetes might want to take insulin for five years diagnosis, while in individuals with type 1 diabetes it is often required on the diagnosis stage.

Type 1.5 diabetes is often diagnosed in people over 30probably due to slow progression of the disease. This is higher than the everyday age of diagnosis for type 1 diabetes but lower than the everyday age of diagnosis for type 2 diabetes.

Actions for type 1.5 diabetes genetic and autoimmune risk aspects with type 1 diabetes, resembling specific gene variants. However, evidence also shows that it might be attributable to lifestyle aspects, resembling obesity AND lack of physical activity that are more often related to type 2 diabetes.

What are the symptoms and how are they treated?

The symptoms of type 1.5 diabetes vary greatly from individual to individual. Some people haven’t any symptoms in any respect. However, typically, people may experience the next symptoms symptoms:

  • increased thirst
  • frequent urination
  • tiredness
  • blurred vision
  • unintentional weight reduction.

Typically type 1.5 diabetes is initially treated with oral medications to maintain blood glucose levels inside normal limits. Depending on glucose control and medications taken, individuals with type 1.5 diabetes might have to watch their blood glucose levels often throughout the day.

When average blood glucose levels rise beyond the conventional range even with oral medications, treatment may switch to insulin. However, there are It is not widely accepted strategies for the management and treatment of type 1.5 diabetes.

(*1*)
Type 1.5 diabetes could be treated orally, at the least initially.
Dragana Gordic/Shutterstock

Type 1.5 diabetes is often misdiagnosed

Lance Bass said he was initially diagnosed with Type 2 diabetesbut later he came upon that he actually has type 1.5 diabetes. That is not exactly rareEstimates suggest that type 1.5 diabetes is misdiagnosed as type 2 diabetes 5-10% of the time.

There are several possible reasons for this state of affairs.

First, to properly diagnose type 1.5 diabetes and distinguish it from other kinds of diabetes, it is essential to conduct special tests. antibody tests (a type of blood test) to detect autoimmune markers. Not all healthcare providers necessarily order these tests routinely, either due to concerns about cost or because they might not consider them.

Second, type 1.5 diabetes is common in adults, so doctors may wrongly assume that a person has developed type 2 diabetes, which is more common on this age group (whereas type 1 diabetes often affects children and young adults).

Thirdly, individuals with type 1.5 diabetes often initially produce enough insulin within the body to manage blood glucose without having to start out insulin treatment. This could make their condition resemble type 2 diabetes, wherein people also produce some insulin.

Because type 1.5 diabetes has symptoms that are just like type 2 diabetes, it might be initially treated as type 2 diabetes.

We are still learning about type 1.5

Compared to type 1 and type 2 diabetes, significantly fewer studies have been conducted on the incidence of type 1.5 diabetes, especially in non-European populationsIt is estimated that in 2023, type 1.5 diabetes will account for 8.9% all cases of diabetes, which is just like type 1 diabetes. However, more research is needed to get exact numbers.

Overall, awareness of type 1.5 diabetes was limited and unclear diagnostic criteria which has slowed down our knowledge of this condition.

Misdiagnosis could be stressful and confusing. For individuals with type 1.5 diabetes, misdiagnosis with type 2 diabetes can mean they don’t get the insulin they need at the precise time. This can result in worsening health and a greater likelihood of complications in the long run.

Getting the precise diagnosis helps people get probably the most appropriate treatment, lower your expenses and reduce their risk. Diabetic sufferingIf you experience symptoms which will indicate diabetes or have concerns about your diagnosis, monitor your symptoms and seek advice from your doctor.

This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Health and Wellness

Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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