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Do Plastics Cause Autism? Here’s What the Latest Research Really Says

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AND test recently it got here to light, which caused quite a lot of media attention on the role of plastics in the development of autism.

The study looked specifically at exposure to the hard plastic ingredient bisphenol A, or BPA, in the womb and the risk of boys developing this neurodevelopmental disorder.

Importantly, the study didn’t find that plastics containing BPA had an impact on autism.

However, it does suggest that BPA may affect estrogen levels in infant and school-age boys, which can impact their risk of being diagnosed with autism.

Let’s take a more in-depth have a look at the details.

Remind me what BPA is?

BPA is a component of hard plastics which have been used for several many years. Because BPA is present in plastics used to make food and a few beverage containers, many persons are exposed to low levels of BPA on daily basis.

But worries The impact of BPA on our health has been circulating for a while, as this substance can, to a small extent, mimic the motion of the hormone estrogen in our bodies.

Even though this effect is weak, there are health concerns because we’re exposed to low levels throughout our lives. Some countries have ban on the use of BPA in baby bottlesas a precaution; Australia is voluntary withdrawal in baby bottles.

What is autism and what causes it?

Autism is a neurodevelopmental disorder diagnosed on the basis of difficulties with social communication and repetitive and/or restrictive behaviours.

People with autism may experience other problems, comparable to seizures, changes in motor skills (for instance, difficulty coordinating high quality movements comparable to holding a pencil or turning a key to open a door), anxiety, sensory issues, sleep problems, and bowel upset.

The severity of those symptoms varies greatly, making individuals with autism perceive on a regular basis life in a very different way.

To date, most studies have described autistic people who find themselves capable of interact thoroughly in the community, and will in reality reveal outstanding skills in some areas. However, there may be a big gap in our knowledge about the large variety of individuals with profound autism who require 24-hour care.

There is a powerful influence genetics in autism with over 1,000 genes related to it. But we do not know what causes autism normally. There are several reasons for this.

It isn’t standard practice to perform detailed gene sequencing in children with autism. Although there are some clear individual genes Although certain genes are answerable for some forms of autism, more often autism may result from a fancy interaction of many genes that may be very difficult to detect, even in large-scale studies.

Environmental aspects can even contribute to the development of autism. For example, some anticonvulsant drugs These drugs aren’t any longer prescribed to pregnant women attributable to an increased risk of their children developing neurodevelopmental disorders comparable to autism.

The latest study looks at one other possible environmental factor: BPA exposure in the womb. The research consisted of several parts, including studies in humans and mice.

What did they discover in humans?

Scientists checked out a gaggle (or cohort) 1074 Australian children; about half were boys. They found that 43 children (29 boys and 14 girls) had been diagnosed with autism between the ages of seven and 11 (average age 9).

They collected urine from 847 moms near the end of pregnancy and measured the amount of BPA. They then focused their evaluation on the samples with the highest levels of BPA.

They also measured genetic changes by analyzing blood from the umbilical cord at birth. This was to ascertain for activity of the enzyme aromatase, which is linked to estrogen levels. Babies with genetic changes that might indicate lower estrogen levels were classified as having “low aromatase activity.”

Pregnant women provided urine samples, and after delivery, blood from their umbilical cord was analyzed.
Natalia Deriabina/Shutterstock

The research team found an association between high maternal BPA levels and a greater risk of autism in boys with low aromatase activity.

In the final evaluation, the researchers found that there have been too few girls with autism diagnoses and low aromatase levels to investigate. So their conclusions were limited to boys.

What did they discover in mice?

The team also studied the effects of exposing mice to BPA in the womb.

Mice exposed to BPA in this fashion showed increased grooming behavior (purportedly indicative of repetitive behavior) and decreased social behavior (purportedly indicative of decreased social interaction).

The team also noted changes in the amygdala region of the brain following BPA treatment. This region is essential for processing social interactions.

The researchers concluded that prime levels of BPA may impair the activity of the aromatase enzyme, which in turn affects estrogen production and modifies the way neurons grow in the brains of mice.

But we ought to be cautious about the results of mouse studies for several reasons:

  • we cannot assume that mouse behavior directly translates into human behavior

  • Not all mice got BPA by the same method – some were injected under the skin, others got BPA in a sweet jelly. This could affect the level of BPA the mice actually received or the way it was metabolized

  • the every day dose administered (50 micrograms per kilogram) was above the levels people in Australia would have been exposed to concentrations much higher than those detected in the urine of the moms participating in the study.

What is the message?

Finding a link between two aspects – on this case, BPA exposure in the womb and autism – doesn’t mean that one causes the other.

But researchers are proposing a mechanism, based on a study in mice. They propose that prime levels of BPA may suppress the enzyme aromatase, altering estrogen production and modifying the way neurons grow in the brains of mice.

Have we discovered what causes autism? Based on this study alone, no. Not all the children of ladies with BPA of their urine had autism, so exposure to those plastics alone isn’t enough to cause autism. There are likely various aspects, including genetics, that contribute.

This study suggests, nonetheless, that there could also be a gene-environment interaction, and that children with certain genetic variants could also be more liable to the effects of BPA and have an increased risk of autism. But we’d like more research to make clear this.

It is essential to know that there are numerous other possible contributors to autism for which there is analogous evidence. Ultimately, we still have no idea needless to say what causes autism in most individuals.

This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Health and Wellness

Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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