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Women with epilepsy struggle with hormonal fluctuations and epileptic seizures. But we treat them like men

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ABOUT 50 million people suffers from epilepsy everywhere in the world. Half of them are women.

So far, treatment for girls and men has been an identical. However, men and women experience epilepsy otherwise.

For women, fluctuating hormones – from reproductive years through pregnancy, perimenopause and menopause – can affect frequency attacks at many stages of their life.

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As we describe in our recent articlewe must take this under consideration and adapt therapies for girls accordingly.

What is epilepsy?

In people without epilepsy, the general electrical activity of the brain is stable. Signals acting on neurons (brain cells) enable a balance between excitation (increased electrical activity of the brain) and inhibition (reduced electrical activity of the brain).

However, in epilepsy this balance is disturbed. When there may be a burst of uncontrolled electrical activity, some or the entire neurons are momentarily over-excited or operating in an “overdrive” mode. This results in a seizure (or seizure).

This disruption can occur unpredictably, a bit like an earthquake by which a seizure occurs unexpectedly and then normally ends abruptly.

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Epilepsy can seriously affect people quality of life. The risk of epilepsy can also be increased in people with epilepsy premature death not only on account of epilepsy itself, but additionally other complications of seizures and suicide.

What role do hormones play?

The hormones estrogen and progesterone are produced within the ovaries and brain. Regardless of whether a lady has epilepsy or not, the degrees of those hormones change throughout her life. However, epilepsy can affect the production of estrogen and progesterone.

Estrogen signals generally greater electrical activity and progesterone signals less. The ratio of those two hormones is significant for the right balance of electrical activity within the brain.

However, an unfavorable relationship disturbs the balance, resulting in an avalanche of symptoms.

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Some specific one anticonvulsants it will probably also change this ratio by reducing estrogen and progesterone levels.

Let’s take the instance of “catamenic epilepsy,” which one study reports about half women with epilepsy.

With such a epilepsy, women may experience more seizures at certain times during their menstrual cycle. This happens most frequently just periods when progesterone levels drop and the estrogen to progesterone ratio changes. In other words, progesterone appears to guard against seizures.

Perimenopause is one other time of hormonal changes. If a lady suffers from catamenic epilepsy, this could lead to a rise within the variety of attacks during perimenopause, when the degrees of each hormones grow to be irregular and periods grow to be more irregular. However, during menopause, when each hormone levels are consistently low, a decrease within the variety of seizures is observed.

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Scientists do long known concerning the cyclical nature of fluctuations in reproductive hormones in women and their impact on epilepsy. However, this has not yet translated into the way in which we treat women.

What should we do?

We urgently need to research how hormonal fluctuations at different stages of a lady’s life affect her epilepsy and quality of life.

We need to raised understand whether we can reduce the frequency of seizures progesterones at certain times of the menstrual cycle. We also need to raised understand whether estrogens (menopausal substitute therapy, also referred to as hormone substitute therapy or HRT) may worsen seizures later in life.

If we don’t investigate the impact of hormonal fluctuations on epilepsy, we risk not treating the particular trigger that causes epileptic seizures in many ladies.

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About 30% women with epilepsy don’t reply to pharmacological treatment. We don’t know the way much of that is on account of hormonal aspects.

However, we know that seizures play an enormous role in increasing the burden of this disease. And this weight will be improved by higher treatment of seizures.

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This article was originally published on : theconversation.com
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Health and Wellness

I am a medical forensic examiner. Here’s what people can expect from a health response from sexual assault

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Estimated one in five women and one in 16 men In Australia, she experienced sexual violence.

After such a traumatic experience, it’s comprehensible that many are usually not sure in the event that they wish to report it to the police. In fact, Less than 10% Australian women who experience sexual assault, if he gives a police report.

In Australia it’s No closing date After notifying the sexual assault to the police. However, there are strict time frames for collecting forensic evidence, which can sometimes be a very important a part of a police investigation, no matter whether it begins.

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This implies that the choice whether to undergo a medical forensic examination should be taken quite quickly after the assault.

I work as a medical forensic examiner. Here’s what you can expect for those who present a medical forensic examination after sexual assault.

A team of specialists

There are about 100 sexual assault services in Australia, providing 24-hour care. As with other healthcare areas, there are additional challenges in regional and rural areaswhere there are sometimes further distances from travel and deficiencies.

Sexual assault services in Australia are free, whatever the status of Medicare. To find the closest service, you can call 1800 respect (1800 737 732) or Full stop australia (1800 385 578) who can also provide immediate support for telephone counseling.

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It is very important to call the local sexual assault service before appearing. They can provide victims to experience information and advice to stop delay and make the method as helpful as possible.

Consultations often occur within the Hospital Emergency Department, which has a designated forensic apartment or within the Specialist Forensic Service.

The victim-over is seen by doctor or nurse Trained in the sphere of medical and criminal care. There is a sexual assault, crisis worker or social employee to support the patient and provides advice on advice. This known as “Integrated answer“With medical and psychosocial employees working together.

In most cases, the victim’s survival might also have the presence of his own support person.

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Depending on what the victim is wants, the doctor or nurse will take the history of the robbery to conduct any medical care which may be needed (e.g. emergency anticretation) and conduct the examination.

Sexual assault services are all the time very conscious dishes to victims of selection in the sphere of medical forensic examination. If a person presents a sexual assault service, he can receive advice and medical care without undergoing forensic examinations if he doesn’t wish to.

https://www.youtube.com/watch?v=cglbtgia0ek

Sexual assault services include all sexes.

Collecting forensic samples

Samples collected during a medical forensic examination can sometimes discover the DNA of the perpetrator or intoxicants (alcohol or drugs that can be relevant to the examination). . Possibility window Collecting these samples can be as short as 12 hours or as much as 5-7 days, depending on the character of the sexual assault.

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In most Australia, an adult who has experienced a recent sexual assault, you can offer a medical forensic examination without submitting a report for the police.

Depending on the condition or territory of the forensic samples, you can often store for 3 to 12 months (as much as 100 years in Tasmania). This allows victims of time to survive definitely whether or not they wish to release them to the police for processing.

A health care provider or nurse will take samples using a sexual assault investigation kit or “rape set”.

Collecting these samples may include taking swabs to detect DNA from external and internal genital areas and wherever DNA transfer may occur. This may come from skin cells during which the perpetrator affected the victim’s snack or from body fluids, including sperm or saliva.

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A health care provider or nurse conducting the examination is minimized by re -traumatization, providing information, elections and control of the victim at every stage of the method.

The victim-overhang can often have a support person with him.
Monkey Business Images/Shutterstock

What about sexually transmitted diseases and pregnancy?

During the consultation, the doctor or nurse will address all fears about sexually transmitted infections (sti) and pregnancy if concerned.

In most cases, the danger of sexually transmitted diseases is low. But check tests for 1-2 weeks by way of infection, reminiscent of chlamydia and gonorrhea, and after 6-12 weeks In the case of infections reminiscent of syphilis and HIV, it is normally advisable.

Emergency contraception can be provided (sometimes called “in the morning after a pill”) prevent pregnancy. It can be downloaded as much as five days after sexual assault (however the faster) with pregnancy tests advisable after 2-3 weeks.

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Everything has improved over time

When I was a younger doctor at the tip of the 90s, taking foreheads were often chargeable for an busy international trainee and gynecology on the Emergency Department, which regularly managed many patients and had a small training in the sphere of criminalistics. Usually there was no supporting advisor.

Anegdotically each the doctor and the patient were traumatic through this experience. Studies show that when specialized integrated services are usually not provided, a sense of powerlessness of the victim They are enlarged.

But the way in which we conduct medical forensic examinations after sexual assault in Australia has improved through the years.

Thanks to practices focused on the patient and the appointed criminal and advisory staff, the patient’s experience is believed Strengthening position than for re -traumatizing.

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A sign before the Australian police station.
Less than 10% of Australian women who experience sexual assault, in the event that they even submit a police report.
Melissa Meehan/AAP

Our research

In latest studies published in Australian Journal of General PracticeMy colleagues and I studied the experience of medical criminal examination from the angle of a victim.

We analyzed 291 patients who provide sexual assault services in New South Wales (where I work) for 4 years.

About 75% of patients said that the study was calming and one other 20% said it was high-quality. Only 2% said it was traumatic. Most (98%) stated that they’d recommend a friend present within the service of sexual assault in the event that they were in a similar situation.

While patients talked positively in regards to the care received, many commented that the sexual assault service was not visible enough. They didn’t know learn how to find it and even existed.

We know that many victims’ victims don’t present a sexual assault service or undergo a medical forensic examination after sexual assault. So we must do more to extend the visibility of those services.

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This article was originally published on : theconversation.com
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Health and Wellness

Milan Fashion Week rejects the classics – essence

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“It’s boring, boring, boring,” said the deceased André Leon Talley from Milan Fashion Week in an interview with 1998 with Videofashion. His own words: “You can go for a week of concerts in a city like Milan, and you sit there and want to jump from the shelf until you reach Gucci.” Italian fashion, like Italian culture, is kind of conservative in comparison with the remainder of the fashion capitals, apart from brands corresponding to Moschino, Versace and Roberto Cavalli, where there are more.

New York is full of life and democratic. London is normally suggestive, filled with creative genius. Paris transfers fashion to the highest heights. And a city whose fashion is usually in comparison with Milan, large for craft – and Flash – is understood for designers who bored fashion fanatics, but they’re sublime. It can be filled with family businesses corresponding to Prada and Fendi. I mean, give it some thought, all of us love pasta, since it is reliably tasty, pizza is the default when nobody in the room can resolve what to eat, and it’s rare that any of those disappoints the palate. In this fashion I see Milan Fashion Week. You know what you’ll get and it should be nice.

The prospects have now opened a bit, and designers corresponding to Maximillian Davis and Matthieu Blazy Zhuzs Up Italian trick, corresponding to Ferragamo and Bottega Veneta. Several other designers have also strengthened the energy of the week with more vivid clothes. But let’s bring it back to Talley. What is “boring” in fashion now? In this fashion, people dress, and “quiet luxury” remains to be guilty. It seems that Milan programs this season help to initiate an era that claims that it energy energy again: easy with a funny return.

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Jil Sander’s clothes bloom

Milan Fashion Week imprints the classics
Giovanni Giannoni/WWD via Getty Images

With the exception of 1 blue and one red leather look and a buffed pink dress with columns, the colours in the Jil Sander collection are quite neutral. These are the details they like: double stripes that don’t beg to be noticed, fur at the top of the shirt and coat collars and on the sleeves, sporadically feathered dress and sweater. The collection began with the honest participation of its clothes, which flicker with fringes, giving it an actual party atmosphere. The lace cover worn on white organza and high black shoes caused a distinct approach to an office dressing, wherein explicit, girlish femininity can coexist with elegant improvement. Many women can look and run with them, like men, with their close bags, nonchalan skirts and Rockstar shoes. This program was the final presentation of the husband and wife’s duo who’re apparently Ending their time in the brand: Luke and Lucia Meier (they began running the house in 2017).

Marni animated runway

Milan Fashion Week imprints the classics
Victor Virgin/Gamma-RPHO by Getty Images

When there have been rumors about who would take over Chanel after the VIARD VIARD leaving the brand, I used to be hoping that one in all Jeremy Scott was real. Because fashion desperately needs humor. Nowadays, every little thing is so tense and few people seem funny. Except for, say, Jonathan Anderson and Francesco Risso in Marni. Ready to wear the brand this season, it looked as if it would a mix of ideas in other concert events over the past few seasons, making a sort of carrying a horse.
There was a kamea from such a classy Tracee Ellis Ross-I can not give you a greater casting decision. The neck of the curly sweater of the follicle captivated me. In combination with it there have been brown suede pants and glossy, multi -colored Oxfords, which delivered to mind shoes with a faucet. The pink bubble rubber coat had buttons, a collar and a breast pocket. Another coat, blue, had gray fur. Apart from the fabrics and color, they enlivened these clothes, these are prolonged proportions, which is all the time fun. This is a miserable thing that makes you ought to watch again.

Fendi celebrates a mode century

Milan Fashion Week imprints the classics
Giovanni Giannoni/WWD via Getty Images

Fendi celebrated a centenary with a program that she threw light on why it was so heralded. The tailoring was liquid, daring prints, and the coats beautiful. And we now have Silvia Venturini Fendi to thank. Many stories were told here. There is, in fact, the history of the House of Craft Fur Production, which took shape in coats with a collar with out a collar, long vests and steles. Deep shades in eye-catching productions emphasize wealth-aestly and economically-we are going to have the ability to with Fendi.

General coats and sick ladyiste dresses, cut out, were smooth butter, quality people have recently loved the brand. Sneaky cardigans, skirts, dresses and sweater have been decorated with drags and countless shapes. The dolls took place and hung from the bags. This created a set that spoke with a consumer and culture, not only to himself. The advantage of the brand was that it didn’t depend on her archives. It was not on the nose together with his references. Instead, it remained fresh, next to other collections, but was expected one step over them

Burberry is on itself

Milan Fashion Week imprints the classics
Giovanni Giannoni/WWD via Getty Images

Daniel Lee’s works in the cult British label people query the brand’s evolution and what means to stay faithful to its history. Industry and its viewers have two minds: some imagine that the home is flourishing when it draws from its heritage, only barely improving him to keep up significance; Others have a more progressive perspective, observing, fairly exactly that fashion is the most when the brands are approaching friends. Christopher Bailey and Riccardo Tisci’s Burberry hit many as unknown. The recent, sometimes dizzying ideas of those designers apparently “did not work”, and on this desire that folks would feel as in the event that they knew the brand again.

Enter: Lee, who joined the label from Bottega Veneta, and whose clothes are easier on the eye, like the current Bottega. His Fall 2025 collection had a really desirable appearance of the same colours, a big sweater dress, a rather glitter leather coat in navy blue blue and other “oooos”, but often “Aaah”. In many respects, clothes sell, adapting to other elements in the collection and translating well into real life, life that’s interesting and dressed as such.

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This article was originally published on : www.essence.com
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Health and Wellness

Odra situation around the world: less vaccinations and more explosions

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The US has registered their first death from the Oder since 2015. This week, because a baby who was not vaccinated died in the Odra eruption in Texas.

Usually, most American cases are delivered to the country by individuals who traveled abroad. Until now, Texas officials have reported 124 cases. New Mexico reported nine.

Experts point to a decrease in vaccination indicators from the Odra around the world since the Covid-19 pandemic. In the United States, most of the states are currently below 95% of the vaccination threshold for preschoolers – the level needed to guard the community from the Oder’s explosions.

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Great Britain reported 2911 confirmed cases of the Oder in 2024, the highest variety of cases recorded yearly, from 2012.

The cases of the Odra in the United States last yr were almost twice as much as for all 2023, raising concerns a few child virus preventive. Health officials confirmed the cases of measles in a minimum of 18 states in 2024, including New York, Philadelphia and Chicago.

“Odra is a threat everywhere anywhere,” say American Center for Disease Control on its website.

Here is a brief have a look at the global situation of the Oder.

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Are the Odra explosions common outside the USA?

According to the World Health Organization, about 10.3 million people were infected in 2023 and 107,500 died. Most of them are unvaccinated people or children under the age of 5. Cases were most frequently partly of Africa, the Middle East and Asia, where the income is low and health services insufficient.

In places where measles were largely eliminated, cases spread by travelers from other countries.

While the measles related to the Odra decreased barely in 2023, the variety of epidemic increased. The primary explosions took place in 57 countries in 2023, including India and Indonesia, Russia, Yemen and Iraq. The largest variety of cases in 2023 was 311,500 in the Democratic Republic of Congo.

What is the impact of vaccinations?

The global childhood vaccination rate has dropped in recent times, to 83% in 2023 from 86% in 2019, partly as a consequence of vaccination and healthcare disturbances as a consequence of pandemic.

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WHO estimates that vaccinations have helped to forestall over 60 million deaths around the world in the years 2000–2023, as shots increase to extend arrows for more people. In 2000, it’s estimated that 800,062 people died of measles. Before introducing the vaccine in 1963, the primary epidemics caused about 2.6 million deaths a yr.

Odra is so infectious that 95% immunity is required to forestall an epidemic, says WHO. In other words, he infects about 9 out of 10 people revealed in the event that they shouldn’t have immunity.

What international efforts are in the means of stopping an epidemic?

WHO and others support the effort called “Agenda Immunization 2021-2030” to press the Odra elimination.

Independent experts announced America -free America in 2016, but this status was lost in 2018 as a consequence of the Odra epidemic in Brazil and Venezuela. Experts say that reduced vaccination indicators undermine efforts to completely eliminate the disease.

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Global health organizations and other groups have increased their efforts to speed up vaccination programs and closure of gaps in prevention.

Shaboozey's

(Tagstranslat) receiving measles

This article was originally published on : thegrio.com
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