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From immunotherapy to mRNA vaccines, the latest science in melanoma treatment explained

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Over 16,000 Australians might be diagnosed with melanoma yearly. Most of them might be detected early and may be treated surgically.

However, for patients with advanced melanoma or metastatic melanoma that has spread from the skin to other organs, the outlook was bleak until the advent of targeted therapies (attack specific features of the cancer) and immune therapies (that harness the immune system). Over the past decade, the variety of patients with advanced melanoma using these treatments has increased significantly survive for not less than five years after diagnosis, from lower than 10% in 2011 to roughly 50% in 2021.

While that is great news, there are still many melanoma patients who can’t be treated effectively with current therapies. Scientists have developed two exciting recent therapies which can be being evaluated in clinical trials in patients with advanced melanoma. Both require the use of immunotherapy at different times and in other ways.

The first results of this study are actually being made publicly available, providing insight into the way forward for melanoma treatment.

Immunotherapy before surgery

Immunotherapy works by increasing the strength of the patient’s immune system to help kill cancer cells. One sort of immunotherapy uses so-called “immune checkpoint inhibitors.”

Immune cells carry “immune checkpoint“proteins that control their activity. Cancer cells can interact with these checkpoints, turning off immune cells and hiding from the immune system. Immune checkpoint inhibitors block this interaction and help keep the immune system lively in fighting cancer.

Results from an ongoing Phase 3 trial of immune checkpoint inhibitors were recently published in a journal New England Journal of Medicine.

This study used two forms of immune checkpoint inhibitors: nivolumab, which blocks an immune checkpoint called PD-1, and ipilimumab, which blocks CTLA-4.

More than 16,000 Australians are diagnosed with melanoma every year.
Delovely Pics/Shutterstock

The study enrolled roughly 423 patients (many from Australia) and participants were randomly assigned to certainly one of two groups.

The first group underwent surgery to remove the melanoma after which received immunotherapy (nivolumab) to help kill the remaining cancer cells. Giving systemic (whole body) therapy, equivalent to immunotherapy, after surgery is: standard way melanoma treatment. The second group first received immunotherapy (nivolumab plus ipilimumab) after which underwent surgery. This is a brand new approach to the treatment of those cancers.

Based on previous observationsresearchers predicted that giving immunotherapy to patients while the tumor was still present could be rather more effective at activating the patient’s immune system’s ability to fight the cancer than giving it after the tumor had been removed.

Indeed, 12 months after starting therapy, 83.7% of patients who received immunotherapy preoperatively remained cancer freecompared with 57.2% in the control group who received immunotherapy after surgery.

Based on these results, Australian of the Year Georgina Long – who co-led the study with Christian Blank from the Netherlands Cancer Institute – suggested that this approach to pre-operative immunotherapy needs to be considered a brand new standard of look after high-risk stage 3 melanoma. She also said the same strategy needs to be evaluated for other cancers.

Promising results from this phase 3 trial suggest that this mix treatment could possibly be used in Australian hospitals over the next few years.

mRNA vaccines

Another emerging type of melanoma therapy is the postoperative combination of one other checkpoint inhibitor (pembrolizumab, which blocks PD-1) with a messenger RNA vaccine (mRNA-4157).

Although checkpoint inhibitors equivalent to pembrolizumab have been around for over a decade, mRNA vaccines equivalent to mRNA-4157 are a more moderen phenomenon. However, you could be aware of mRNA vaccines as biotech firms Pfizer-BioNTech and Moderna have released them Covid vaccines based on mRNA technology.

mRNA-4157 works in essentially the same way – mRNA is injected right into a patient and produces antigens, that are small proteins that train the body’s immune system to attack the disease (in this case cancer, or in the case of Covid-19, the virus).

However, mRNA-4157 is exclusive – literally. This is a sort of personalized medicine in which mRNA is created specifically for the needs of the patient’s cancer. First, the patient’s tumor is genetically sequenced to determine what antigens will best help the immune system recognize the cancer. A patient-specific version of mRNA-4157 is then created to produce these antigens.

The latest results of a three-year Phase II clinical trial combining pembrolizumab and mRNA-4157 have been published announced last week. Overall, 2.5 years after study initiation, 74.8% of patients treated with immunotherapy combined with mRNA-4157 were freed from cancer after surgery compared with 55.6% of patients treated with immunotherapy alone. These were patients affected by high-risk late-stage melanoma they typically perform poorly.

It is value noting that these results haven’t yet been published in peer-reviewed journals. They can be found as corporate announcements and have also been presented at some oncology conferences in the United States.

Based on the results of this study, pembrolizumab and vaccine combination therapy achieved: phase 3 trial in 2023, with first patients is registered in Australia. However, the final results of this study aren’t expected until 2029.

The hope is that this mRNA-based cancer vaccine will pave the way for vaccines targeting other forms of cancer, not only melanoma, especially when combined with checkpoint inhibitors that may help stimulate the immune system.

Despite continuous progress in the treatment of melanoma, the best way to fight cancer remains to be prevention, which in the case of melanoma means, every time possible, protection against exposure to UV radiation.



This article was originally published on : theconversation.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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