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Biased testing prevented thousands of Black people from receiving kidney transplants. This is finally changing

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PHILADELPHIA (AP) — Jazmin Evans had been waiting for a brand new kidney for 4 years when her hospital revealed shocking news: She must have been placed on the transplant list in 2015, not 2019 — and racist organ testing was responsible.

While this announcement was upsetting, it was also part of an unprecedented effort to alleviate racial inequality. Evans is amongst greater than 14,000 black kidney transplant candidates who’ve to this point been given credit for lost waiting time, moving them up the priority list for a transplant.

“I remember reading this letter over and over again,” said Evans, 29, of Philadelphia, who shared the data in a TikTok video to teach other patients. “How could this happen?”

At issue is a once widely used test that overestimated kidney function in black people, making them appear healthier than they really were – all because of an automatic formula that calculated results otherwise for black and non-black patients. This race-based equation can delay diagnosis of organ failure and evaluation for transplant, exacerbating other disparities that already make Black patients more more likely to need a brand new kidney but less more likely to receive one.

Several years ago, the National Kidney Foundation and the American Society of Nephrology pushed labs to modify to race-free equations in calculating kidney function. The U.S. Organ Transplant Network then ordered hospitals to make use of only race-neutral test results when adding latest patients to the kidney waiting list.

“The query immediately arose: what concerning the people currently on the list? You cannot just leave them there,” said Dr. Martha Pavlakis of Boston’s Beth Israel Deaconess Medical Center and former chairwoman of the network’s kidney committee.

Pavlakis calls what happened next an try to restore justice: The transplant network gave hospitals a yr to find which Black kidney candidates may need previously qualified for a brand new kidney if not for a race-based test — and adjusted wait times to compensate. . For each newly listed black patient, a retrospective review is performed to see if he, too, must have been referred earlier.

According to the United Network for Organ Sharing, which operates the transplant system, from January 2023 to mid-March, the wait for a Black kidney transplant was reduced by a mean of two years for greater than 14,300 Black kidney transplant candidates. So far, greater than 2,800 of them, including Evans, have received a transplant.

But this is only one example of a bigger problem pervading health care. The quite a few formulas or “algorithms” used to make medical decisions – treatment guidelines, diagnostic tests, risk calculators – tailor answers to race or ethnicity in ways in which drawback people of color.

Given how embedded these equations are in medical software and electronic records, even physicians may not realize how widely they influence care decisions.

Jazmin Evans prepares medications after her kidney transplant in February at home in Philadelphia. (Photo: Tassanee Vejpongsa/AP)

“Health equity researchers have been raising alarms about the inappropriate use of race in clinical algorithms for decades,” said Dr. Michelle Morse, New York City’s chief medical officer.

Change begins slowly. Obstetricians should not consider race when determining a pregnant woman’s risk of attempting a vaginal delivery after a previous cesarean section. The American Heart Association just removed race from its widely used heart disease risk calculator. The American Thoracic Society has pushed for the alternative of lung function assessments based on race.

The kidney saga is unique in its try to right a incorrect from the past.

“A lot of the time when we see health inequities, we just assume there’s nothing we can do about it,” Morse said. “We can make changes to restore faith in the health care system and actually address the unfair and avoidable outcomes that Black people and other people of color face.”

Black Americans are greater than 3 times more more likely to suffer from kidney failure than whites. Of the roughly 89,000 people currently on the waiting list for a brand new kidney, about 30% are black.

Race is not a biological factor like age, gender or weight – it is a social construct. So how did it find yourself within the kidney function calculations?

eGFR, or estimated glomerular filtration rate, assesses kidney health by how quickly a waste compound called creatinine is filtered from the blood. Due to a long-held false theory about differences in creatinine levels, many laboratory reports until recently often listed two results – one calculated for non-black patients and the opposite for black patients – which can have overestimated kidney function by as much as 16%. .

This is not the case for each Black kidney candidate. Some people can have been diagnosed with kidney failure without this test. To give others a likelihood to learn from UNOS’s required retrospection, transplant center workers-turned-detectives often worked additional time and on weekends, trying to find years of data for a test that, if recalculated without taking race under consideration, could possibly be significant.

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“You contact your nephrologist, primary care physicians and dialysis units to get this data,” said Dr. Pooja Singh of the Jefferson Health transplant institute in Philadelphia, where Evans received her latest kidney. “That first patient transplant for us was such a great moment for our program that it didn’t feel like work after that.”

A highschool sports physical therapist first noticed Evans’ kidney disease at age 17. She was ending her master’s degree and beginning to earn her Ph.D. at Temple University, she began dialysis – nine hours a day while she slept – and was placed on the transplant list.

The time it takes for a kidney transplant is dependent upon the patient’s blood type, the urgency of treatment and a number of other aspects, including how long they’ve been on the waiting list. Evans first made the list in April 2019. When the Jefferson transplant center found her old lab tests, they found she must have qualified in September 2015.

“For context, when I was still a student, I should have been on the list,” she said, recalling the anger she felt when reading the letter. What she called a “staggering” credit, one other 3.5 years of waiting, also provided a “glimmer of hope” that she would soon receive an identical kidney.

Evans received a brand new kidney on July 4 and is healthy again and is grateful that the policy change got here in time for her.

“It is not known whether people would be alive today” if this law had been introduced earlier, she said. Still, this extra step of “making amends for those we can, I think is very important and necessary if you really want to bring more equity and equality in the medical field.”


This article was originally published on : thegrio.com
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Health and Wellness

Jury awarded $310 million to parents of teenager who died after falling on a ride at Florida amusement park – Essence

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Sun Sentinel/Getty Images

The family of Tire Sampson, the 14-yr-old who tragically died on an amusement park ride in Orlando, Florida, in 2022, has been awarded $310 million in a civil lawsuit.

Tire, who was visiting ICON Park along with his family on March 24, 2022, fell from the FreeFall drop tower. Although he was taken to a nearby hospital, he didn’t survive his injuries.

Now, greater than two years later, a jury has held the vehicle manufacturer, Austria-based Funtime Handels, responsible for the accident and awarded the Tire family $310 million. According to reports from local news stations WFTV AND KSDKthe jury reached its verdict after about an hour of deliberation.

Tyre’s parents will each receive $155 million, according to attorney spokesman Michael Haggard.

Attorneys Ben Crump and Natalie Jackson, who represented Tyre’s family, shared their thoughts on this landmark decision via X (formerly Twitter). “This ruling is a step forward in holding corporations accountable for the safety of their products,” they said in a statement.

Lawyers stressed that Tyre’s death was attributable to “gross negligence and a failure to put safety before profits.” They added that the ride’s manufacturer had “neglected its duty to protect passengers” and that the substantial award ensured it could “face the consequences of its decisions.”

Crump and Jackson said they hope the result will encourage change throughout the theme park industry. “We hope this will spur the entire industry to enforce more stringent safety measures,” they said. “Tire heritage will provide a safer future for drivers around the world.”

An investigation previously found that Tyre’s harness was locked through the descent, but he dislodged from his seat through the 430-foot fall when the magnets engaged. Tire’s death was ruled the result of “multiple injuries and trauma.”

ICON Park said at the time that it could “fully cooperate” with the authorities.

This article was originally published on : www.essence.com
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Tireless HIV/AIDS advocate A. Cornelius Baker dies

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HIV/AIDS Advocate, A. Cornelius Baker


A. Cornelius Baker, a tireless advocate of HIV and AIDS testing, research and vaccination, died Nov. 8 at his home in Washington, D.C., of hypertensive, atherosclerotic heart problems, in response to his partner, Gregory Nevins.

As previously reported, Baker was an early supporter for people living with HIV and AIDS within the Nineteen Eighties, when misinformation and fear-mongering in regards to the disease were rampant.

According to Douglas M. Brooks, director of the Office of National AIDS Policy under President Obama, it was Baker’s Christian faith that guided him toward compassion for others.

“He was very kind, very warm and inclusive – his circles, both professional and personal, were the most diverse I have ever seen, and he was guided by his Christian values,” Brooks told the outlet. “His ferocity was on display when people were marginalized, rejected or forgotten.”

In 1995, when he was executive director of the National AIDS Association, Baker pushed for June 27 to be designated National HIV Testing Day.

In 2012, he later wrote on the web site of the Global Health Advisor for which he was a technical advisor that: “These efforts were intended to help reduce the stigma associated with HIV testing and normalize it as part of regular screening.”

https://twitter.com/NBJContheMove/status/1856725113967632663?s=19

Baker also feared that men like himself, black gay men, and other men from marginalized communities were disproportionately affected by HIV and AIDS.

Baker pressured the Clinton administration to incorporate black and Latino people in clinical drug trials, and in 1994 he pointedly told the Clinton administration that he was bored with hearing guarantees but seeing no motion.

According to Lambda Legal CEO Kevin Jennings, yes that daring attitude that defines Baker’s legacy in the world of ​​HIV/AIDS promotion.

“Cornelius was a legendary leader in the fight for equality for LGBTQ+ people and all people living with HIV,” Jennings said in a press release. “In the more than twenty years that I knew him, I was continually impressed not only by how effective he was as a leader, but also by how he managed to strike the balance between being fierce and kind at the same time. His loss is devastating.”

Jennings continued: “Cornelius’ leadership can’t be overstated. For many years, he was one in all the nation’s leading HIV/AIDS warriors, working locally, nationally and internationally. No matter where he went, he proudly supported the HIV/AIDS community from the Nineteen Eighties until his death, serving in various positions including the Department of Health and Human Services, the National Association of Persons with Disabilities AIDS, and the Whitman-Walker Clinic . Jennings explained.

Jennings concluded: “His career also included several honors, including being the first recipient of the American Foundation for AIDS Research Foundation’s organization-building Courage Award. Our communities have lost a pillar in Cornelius, and as we mourn his death, we will be forever grateful for his decades of service to the community.”

Kaye Hayes, deputy assistant secretary for communicable diseases and director of the Office of Infectious Diseases and HIV/AIDS Policy, in her comment about his legacy, she called Baker “the North Star.”.

“It is difficult to overstate the impact his loss had on public health, the HIV/AIDS community or the place he held in my heart personally,” Hayes told Hiv.gov. “He was pushing us, charging us, pulling us, pushing us. With his unwavering commitment to the HIV movement, he represented the north star, constructing coalitions across sectors and dealing with leaders across the political spectrum to deal with health disparities and advocate for access to HIV treatment and look after all. He said, “The work isn’t done, the charge is still there, move on – you know what you have to do.” It’s in my ear and in my heart in the case of this job.

Hayes added: “His death is a significant loss to the public health community and to the many others who benefited from Cornelius’ vigilance. His legacy will continue to inspire and motivate us all.”

Baker is survived by his mother, Shirley Baker; his partner Nevins, who can be senior counsel at Lambda Legal; his sisters Chandrika Baker, Nadine Wallace and Yavodka Bishop; in addition to his two brothers, Kareem and Roosevelt Dowdell; along with the larger HIV/AIDS advocacy community.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

Bovaer is added to cow feed to reduce methane emissions. Does it pass into milk and meat? And is it harmful to humans?

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There are growing concerns in regards to the use of feed supplements, Bowar 10to reduce methane production in cows.

Bovaer 10 consists of silicon dioxide (mainly sand), propylene glycol (food stabilizer approved by Food Safety Australia New Zealand) and lively substance 3-nitrooxypropanol (3-NOP).

There has been an enormous amount of misinformation in regards to the safety of 3-NOP, with some milk from herds fed this additive being labeled “Frankenmilk”. Others feared it could get to humans through beef.

The most significant thing is that 3-NOP is secure. Let’s clear up some major misconceptions.

Why do we want to limit methane production?

In our attempts to limit global warming, we’ve placed the best emphasis on CO₂ because the major man-made greenhouse gas. But methane is also a greenhouse gas, and although we produce less of it, it is: a much stronger greenhouse gas than CO₂.

Agriculture is the largest a man-made source of methane. As cattle herds expand to meet our growing demand for meat and milk, reducing methane production from cows is a vital way to reduce greenhouse gas emissions.

There are several ways to do that. Stopping bacteria within the stomachs of cows that produce methane one approach is to produce methane.

The methane produced by cows and sheep doesn’t come from the animals themselves, but from the microbes living of their digestive systems. 3-NO stop the enzymes that perform the last step of methane synthesis in these microorganisms.

3-NOP is not the one compound tested as a feed additive. Australian product based on seaweed, Rumin8for instance, it is also in development. Saponins, soap-like chemicals present in plants, and essential oils as well has been examined.

However, 3-NOP is currently one of the popular effective treatments.

Nitrooxypropanol structure: red balls are oxygen, gray carbon, blue nitrogen and white hydrogen.
PubChem

But is not it poison?

There are concerns on social media that Bovaer is “poisoning our food.”

But, as we are saying in toxicology, it’s the dose that makes the poison. For example, arsenic is deadly 2–20 milligrams per kilogram of body weight.

In contrast, 3-NOP was not lethal on the doses utilized in safety studies, up to 600 mg 3-NOP per kg body weight. At a dose of 100 mg per kg body weight in rats, it didn’t cause any adversarial effects.

What about reproductive issues?

The effect of 3-NOP on the reproductive organs has generated numerous commentary.

Studies in rats and cows showed that doses of 300–500 mg per kg body weight caused: contraction of the ovaries and testicles.

In comparison, to achieve the identical exposure in humans, a 70 kg human would want to eat 21–35 grams (about 2 tablespoons) of pure 3-NOP every day for a lot of weeks to see this effect.

No human will likely be exposed to this amount because 3-NOP doesn’t pass into milk – is fully metabolized within the cow’s intestines.

No cow will likely be exposed to these levels either.

The cow licks itself
Cows will not be exposed to levels tested on animals in laboratory studies.
Ground photo/Shutterstock

What about cancer?

3-NOP is not genotoxic or mutagenicwhich implies it cannot damage DNA. Thus, the results of 3-NOP are dose-limited, meaning that small doses will not be harmful, while very high doses are (unlike radiation where there is no secure dose).

Scientists found that at a dose of 300 mg per kilogram of body weight benign tumors of the small intestine of female ratsbut not male rats, after 2 years of every day consumption. At a dose of 100 mg 3-NOP per kg body weight, no tumors were observed.

Cows eat lower than 2 grams of Bovaer 10 per day (of which only 10% or 0.2 grams is 3-NOP). This is about 1,000 times lower than the appropriate every day intake 1 mg 3-NOP per kg body weight per day for a cow weighing 450 kg.

This level of consumption will likely be not the result in cancer or any of them other adversarial effects.

So how much are people exposed to?

Milk and meat consumers will likely be exposed to zero 3-NOP. 3-NOP doesn’t penetrate milk and meat: is completely metabolized within the cow’s intestines.

Farmers could also be exposed to small amounts of the feed additive, and industrial employees producing 3-NOP will potentially be exposed to larger amounts. Farmers and industrial employees already wear personal protective equipment to reduce exposure to other agricultural chemicals – and it is advisable to do that with Bovear 10 as well.

Milk
3-NOP doesn’t penetrate milk and meat.
Shutterstock

How widely has it been tested?

3-NOP has been in development for 15 years and has been subject to multiple reviews by European Food Safety Authority, UK Food Safety Authority AND others.

It has been extensively tested over months of exposure to cattle and has produced no unintended effects. Some studies actually say so improves the standard of milk and meat.

Bovaer was approved for use in dairy cattle by the European Union from 2022 and Japan in 2024. It is also utilized in many other countries, including: in beef products, amongst others Australia.

A really small amount of 3-NOP enters the environment (lower than 0.2% of the dose taken), no accumulates and is easily decomposed subsequently, it doesn’t pose a threat to the environment.

Since humans will not be exposed to 3-NOP through milk and meat, long-term exposure is not an issue.

What does Bill Gates have to do with this?

Bill Gates has invested in a distinct feed processing method for methane, Australian seaweed-based Rumin8. But he has nothing to do with Bovaer 10.

The Bill & Melinda Gates Foundation awarded research grants to the corporate producing 3-NOP for malaria control researchnot for 3-NOP.

The bottom line is that adding 3-NOP to animal feed doesn’t pose any risk to consumers, animals or the environment.

This article was originally published on : theconversation.com
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