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Oprah Winfrey opens its experience of menopause in the new special “menopause revolution”

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Oprah Winfrey speaks to save lots of other women from suffering in silence. In his upcoming hul Special Winfrey will discover menopause and its different impact on women.

“When I was undergoing menopause, I couldn’t sleep for two years. I couldn’t concentrate. I couldn’t read my favorite books. I had a palpitations. Nobody told me about it. Now we are talking about it, so no woman suffers from it,” she wrote, “she wrote further Facebook.

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According to National Institute of Health (Nih)Menopause is a stage of a lady’s life when her menstrual periods stop permanently and may not get pregnant. However, this natural decrease in women’s reproductive hormones could cause a number of symptoms which are unique to each woman. For Winfrey, the symptoms became so intense that she needed to stop running her popular book club.

“The worst thing for me when I knew I really have trouble when I couldn’t concentrate reading. I love to read so much, but I let go of the book club because I couldn’t concentrate when I read. I couldn’t finish the book anymore,” Winfrey told Winfrey ABC News. “I brought (book club) when I started taking estrogen because I could focus again, but I never really shared the fact that the real reason I had to stop was is that I couldn’t concentrate anymore. It makes me want to cry.”

However, Winfrey didn’t experience any common symptoms of menopause, corresponding to hot flashes or night sweats. Instead, she coped with palpitations, which she didn’t know that they were symptoms of menopause. While society is used to talking about menopause in jokes, for instance, when Clair Huxtable pushed her head into the freezer, when it experienced hot flashes, conversations surrounding menopause are almost non -existent. This explains why Winfrey was not aware of possible symptoms and why he now uses her special hul to make clear this subject and encourage women to medical advice.

“When I went through it, there was nothing. There was nobody. I felt literally as if I had died every night,” she said, explaining the way it took her two years to understand that she was experiencing menopause. “Because it affects every cell in your body, you have any of the symptoms for the first time, then you must find a doctor who listens to you, hear you and take action for you.”

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“Oprah Winfrey Special: The Menopause Revolution” emits tonight at 10/9c on ABC and tomorrow streams on Disney+ and Hulu.

Menopause can cause dentive problems, but you can protect your mouth

(Tagstotranslat) Health

This article was originally published on : thegrio.com

Health and Wellness

TGA approved Donanemab to Alzheimer’s disease. How does this drug work and who will be able to access it?

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This week, Australia Administration of therapeutic goods (TGA) approved the drug called Donanamab for people within the early stages of Alzheimer’s disease.

DonanaMab was previously approved in lots of other countries, including United States.

So what’s Donanemab and who will be able to access it in Australia?

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How does Donanemab work?

There are over 100 different causes dementiaBut Alzheimer’s disease itself accounts for about 70% of them, what to do The most typical form dementia.

It is believed that the disease is brought on by the buildup of two abnormal proteins, amyloid and tau within the brain. It is believed that the primary is especially vital, and the “amyloid hypothesis” – which suggests that amyloid is the important thing explanation for Alzheimer’s disease – he has been conducting research for a few years.

Donanemab is a “monoclonal antibody” treatment. Antibodies are proteins that produce an immune system that’s related to harmful foreign “invaders” within the body or goals. Monoclonal antibodies have one specific purpose. In the case of Donanemab, this is amyloid protein. Donanemab is related to amyloid protein (platelet) protein within the brain and allows our bodies to remove them.

Donanemab is given every month by intravenous infusion.

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What do evidence say?

Australia’s approval appears consequently Clinical examination with the participation of 1736 people published in 2023.

This study showed that Donanemab led to a major slowdown within the progression of the disease in a gaggle of patients who had early Alzheimer’s disease, or mild cognitive disorders with signs of Alzheimer’s pathology. Before starting the study, all patients were detected by amyloid protein SCANNING OF DOMOTION ANIMALS.

Participants were randomized, and half received Donanamab, and the opposite half received placebo inside 18 months.

The accumulation of amyloid plates within the cerebral tissue is the hallmark of Alzheimer’s disease.
Katryna Kon/Shutterstock

For those who received an energetic drug, Alzheimer’s disease progressed 35% more slowly compared to those who received placebo. Scientists have determined this with the assistance Integrated scale of Alzheimer’s disease assessmentwhich measures cognition and function.

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Those who received Donanemab also showed a big reduction in the degrees of amyloid within the brain (measured by PET scans). Most, at the tip of the study, were considered below the brink that may normally indicate the presence of Alzheimer’s disease.

These results actually seem to confirm the hypothesis of amyloids that was caused the query by the outcomes of many Unsuccessful previous tests. They constitute significant progress in our understanding of the disease.

After saying, the patients within the study weren’t when it comes to cognition or function. They were still falling, although at a much slower pace than those who weren’t treated.

The real clinical significance was Debate topic. Some experts wondered if the meaning of this result for the patient is value a possible risk.

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Is the drug protected?

About 24% of participants of the rehearsal of the drug experienced brain edema. The rates increased to 40.6% in those with two copies of the gene called APoe4.

Although three -quarters of individuals who developed brain swelling didn’t experience any symptoms, three deaths took place within the treated group in a study related to Donanemab, probably consequently of brain edema.

This risk require regular monitoring with MRI scans when administering the drug.

About 26.8% of individuals who received Donanemab also experienced small brain bleeding (microemorrhages) compared to 12.5% ​​of placebo people.

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The cost is a barrier

Reports indicate that Donanemab may cost anywhere USD 40,000 and USD 80,000 Every 12 months in Australia. This puts him beyond the reach of many who can use it.

Eli Lilly, producer Donanemab, submitted a request to list the drug within the pharmaceutical profit program several months. Although this would make the medication way more accessible to patients, it could be a high cost for taxpayers.

The cost of the drug is an addition to the prices related to the monitoring required to ensure its safety and effectiveness (corresponding to doctor’s visits, MRI and PET scans).

A younger woman interacts with an older woman in a nursing home. Both look happy.
Donanemab will not be available to all patients with Alzheimer’s disease.
PixelStock/Shutterstock

Who will be able to access it?

This drug is useful for individuals with an early Alzheimer disease, so not everyone with Alzheimer’s disease will gain access to it.

Almost 80% of individuals who were shown to participate within the trial They were considered inappropriate to proceed.

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Conditions TGA approval Specify potential patients, they will first have to have a selected level of amyloid protein of their brains. This would be determined by PET scanning or sampling of lumbar spinal fluid puncture.

In addition, patients with two copies of the APoe4 gene were considered inappropriate to receive the drug. TGA assessed the chance/profit profile in order that this group is unfavorable. This genetic profile is just 2% of the final population, but 15% of individuals with Alzheimer’s disease.

Improving diagnosis and temperament expectations

It is estimated greater than 400,000 Australians They have dementia. But only 13% He currently receives a diagnosis inside a 12 months of developing symptoms.

Considering individuals with very early diseases, so as to profit from this treatment essentially the most, we must significantly expand our diagnostic dementia services.

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Finally, it’s best to alleviate your expectations as to what this drug can be achieved reasonably. It is vital to do not forget that this isn’t a medication.

This article was originally published on : theconversation.com
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Health and Wellness

These are the glasses you need in a make -up bag – essence

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These are the laxts with which you should update the makeup bag

Shutterstock.

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The last Kosmee trends have proven that the shiny finish has never been more fashionable. From glass leather and hair to a polished gel manicure, the fondness around the gluted appearance is sort of unanimous. But before the creation of the erased skin and the vocational leather lids, there was a gloss to the mouth. Dead, thick and never ceases to supply maximum gloss, lip glosses were the best beauty accessory – and so they return. In era 2.0, today’s lip glosses bend into nostalgic elements, while including modern formulations.

Forget about the balls and squeezing the pipes – these glosss provide greater than just gloss. Regardless of whether or not they activate plump ingredients or skincare staples for hydration and hydration, the latest cultivation brings something latest to the category. They are now not sticky or heavy, they’ve light formulas that work as well over lipsticks, for bare lips. But their best function can be the oldest. Like the tubes out of your youth, they supply a mirror gloss and a shiny finish that lasts an hour.

Before us, see the best adult lips to your lips so as to add your collection as soon as possible.

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We independently evaluate all advisable services. If you click the links we offer, we will receive compensation.

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This article was originally published on : www.essence.com
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Health and Wellness

The investigation showed that there are less CDC health warnings

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The study reveals that health warnings from disease control centers (CDC) have It decreased amongst explosions across the country.

As the very best within the country, the healthcare agency, CDC goals to save lots of lives and protect people from health threats through critical scientific research and health information. However, as NPR notes, communication with the audience on its platforms died down or was not recurrently updated, as before.

“It works best when his experts can convey the work they do in real time, and this does not happen,” said Kevin Griffis, former communication director at CDC until March.

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He says that people’s lives could be threatened without critical health updates.

Which has modified to CDC

Before the inauguration of President Donald Trump, CDC managed most of her communication through social media platforms and newsletters. The staff communicated health messages every single day, weekly, monthly and quarterly via their network of 150 Bulletins on topics, including diabetes and food safety.

After the inauguration of President Trump, the Department of Health and Social Welfare, who supervises CDC, instructed CDC to vary his communication. Trump The administration sent directives to HHS, which stopped communication At the National Institutes of Health, FDA and CDC until further notice, reports.

As Americans, the change in CDC in health warnings affects

Social media is considered one of the fastest and effective ways to disseminate CDC information. Doctors, scientists and researchers could quickly update the platforms. CDC has over 13 million people on Instagram, X, Facebook and LinkedIn.

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ACLeading to the NPR study, some publications that died down include CDC and a weekly publication on diseases. This is among the many historical growth of the Oder in some parts of the USA, Salmonella, Listeria and Viral Inflammation A and C.

The approval of HHS is currently a requirement for publishingBut CDC employees told investigators that the health department officials didn’t accept their content Social media.

However, the communication director at HHS Andrew Nixon says that CDC staff spread false rumors.

Looking on the CDC social media account, Last post on the foremost Facebook The page is a reel with germs and humidifiers on March 31 on the time of this report.

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In the last post of May 14, preliminary data showing a decrease in overdose deaths in 2023–2024 was discussed. Post previously responded to the message of May 3 on inaccurate reports.

(Tagstranslate) Centers for control and prevention of diseases (T) CDC (T) Department of Health and Social Welfare

This article was originally published on : www.blackenterprise.com
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