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Predict which patients are at high risk of recurrence to improve outcomes

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Lung cancer is accountable for more deaths than breast, colon and prostate cancer combined.

As lung cancer screening advances, it is predicted that more patients will probably be diagnosed at earlier stages, enabling them to undergo surgery, the first treatment for early-stage patients.

However, in a big proportion of patients after resection (surgery to remove the tumor), the cancer will come back. Unfortunately, current clinical guidelines cannot help predict which patients are at risk. Better knowledge of who’s at risk has essential implications for choosing systemic therapies, akin to chemotherapy, for early-stage lung cancer patients after surgery.

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To find an answer to this problem, our research group at McGill University launched a project in collaboration with Université Laval. Preliminary results were published in . In our work, we found that the use of recent imaging technology combined with artificial intelligence can improve treatment outcomes for cancer patients.

Too much or too little intervention

This clinical dilemma has essential implications for the selection of treatment akin to chemotherapy. For example, lung cancer patients who were cured by surgery could avoid the toxicity of chemotherapy. Patients at risk of cancer recurrence may gain advantage from additional therapeutic interventions.

The challenge of predicting recurrence in patients with early-stage lung cancer has essential implications for the 31,000 Canadians who are diagnosed with this terrible disease annually.

Mass cytometry imaging

To address this clinical problem, we used imaging mass cytometry (IMC), a brand new technology enabling comprehensive characterization of the tumor microenvironment.

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The tumor microenvironment is a fancy ecosystem composed of interactions between tumor cells, immune cells, and various structural cells. IMC will be used to visualize up to 50 markers on the cell surface, which is far more than was previously possible.

This technology makes it possible to discover differing kinds of cells and determine their spatial organization, i.e. the way in which they interact with one another. IMC generates images that will be analyzed to determine the frequency of cell subpopulations, their activation states, the opposite cell types with which they interact, and their organization in cell communities.

The results of our study, published in , reveal that different cell types can interact in cell communities and that communities composed of B cells are strongly related to prolonged survival in lung cancer patients. Our study highlights that beyond cellular frequency, cellular interactions and spatial organization also strongly correlate with essential clinical outcomes akin to survival.

Using artificial intelligence to create higher forecasts

Based on our preliminary results, we hypothesized that essential spatial features embedded in IMC images, akin to cellular interactions, could also be essential in predicting clinical outcomes.

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Our dataset of 416 patients and over 1.6 million cells provided enough power to make predictions using AI. We sought to predict which patients with early-stage lung cancer would experience tumor recurrence after surgery.

Using 1 mm2 tumor samples, material available from surgical resections or biopsies, we used artificial intelligence algorithms together with IMC images to make our predictions. Our algorithm was able to predict with 95% accuracy which patient would experience a cancer recurrence using the spatial information contained in the photographs.

Six markers could make a difference

One of the challenges of applying our results to the clinical setting is that IMC isn’t available. Clinical pathologists typically use less complex technologies akin to immunofluorescence, which are often limited to three or fewer markers.

Immunofluorescence image of a tumor treated with immunotherapy. This technology is commonly limited to using three or fewer tags at a time.
(Shutterstock)

To address this challenge, we sought to determine the minimum number of markers needed to obtain meaningful predictions of disease recurrence in lung cancer patients after surgery. Using six markers, we achieved an accuracy of 93%, which is close to the 95% accuracy achieved using 35 markers.

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These results suggest that by harnessing the ability of artificial intelligence with existing technologies available in hospitals, we may give you the option to improve postoperative clinical management of patients with early-stage lung cancer. Our ultimate goal is to increase cure rates in people at high risk of cancer recurrence while minimizing toxicity in individuals who will be cured surgically.

This article was originally published on : theconversation.com
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Health and Wellness

Safe marina for overwhelmed black women

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The Rest Spot, Atlanta


Smyrna, Georgia, Woman, Jena Burgess Singleton, opened a non-public biological renewal campus only for women entitled The Rest Stoth in June 2024. With one mission: help women discover a protected rest space. Singleton’s activity, satisfied especially towards black women, was born from a private healing journey for her and transformed right into a goal to realize joint healing when she realized that other women were fighting for similar things.

In an interview with Singleton Summoned Her life in 2023, when she felt that she had burdened her life, profession and fears of care.

Singleton remembered: “I was forced to rest. My body reacted physically. I still shock from cortisol; I had face paralysis. My nervous system was fried.”

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Singleton was forced to concentrate on healing her after her doctor ordered her due to her health problems.

“In a sense, it took me a toll because you hear all stories and become a safe space for so many people,” said Singleton. “I feel that between this and only my personal journey of my father in need of a kidney transplant, I had a daughter, I divorced, Covid and George Floyd happened.

Singleton turned it into healing into something that might be divided with others – the trouble that may result in the creation of the remainder.

The entrepreneur has transformed his home right into a healing space, developing naps and inventive spaces. The small sanctuary quickly needed to develop when the requests for protected space appeared at a greater pace than expected.

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Now the remainder is on the land of Earth in Smyrna. The location is positioned in lush green gardens and intentionally chosen vibrations built on calming fragrances for everyone who participates. The primary house of the remainder includes two common rooms, snacks and teas, a library and plenty of others – they’re all chosen to support emotional release for people looking for rest.

Singleton described from work outside the house to the place where the remainder is today.

“I would say that come, I will watch the children, and they went upstairs and they took a nap,” said Singleton. “I had a larger house, so I had two additional rooms and started designing them. I just wanted them to be really comfortable and cozy, and it would become a funny project for me.”

Now the remainder have large supporters of members, of whom about 90% are black women who can book time in various thematic apartments and spaces specializing in various varieties of supplementation to assist sleep, self -reflection and even fair expression. The rest have tools that help women in creative, mental and emotional rest.

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The rest even takes place for moms and doesn’t allow children to care for children to stop women from looking for their advantages.

The Singleton company includes a toddler care package and authorized staff for the care of the youngsters of moms they attend.

Singleton expressed: “For many black women who are members, they gave everyone a child for the first time. They are very excited because you see that they are in delivery. You see he is shaking.”

Singleton emphasizes the supply of the remainder by developing a membership model without traditional barriers to other biological renewal centers. Both meals and childcare are included in the value of membership.

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Prices are between USD 135 and USD 189 for monthly membership.

“We don’t punish women for being mothers. We meet them where they are,” explained the Singleton.

“Loneliness is an epidemic,” she continued. “We have quite a lot of women who are lonely who do not have children, pets or significant others. Women want to feel connected, and want to be with similarly thinking people. Every Thursday, 17–19, we have an social hour, and the chef produces snacks; we drink drinks, and this is a different way in which they will receive something in their membership.”

Singleton hopes to expand the activities in the sector of well -renewal to other parts of the Atlanta area and construct a current campus with seven different apartments.

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(Tagstotranslate) Jena Burgess Singleton (T) The Rest Plot (T) Essence (T) Smyrna Georgia

This article was originally published on : www.blackenterprise.com
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Health and Wellness

More people try healing marijuana because of chronic pain. But does it work?

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More Australians are prescribed than ever Cannabis healing.

The healing quarrel refers back to the legally prescribed cannabis products. They are either the plant itself or naturally occurring ingredients extracted from the plant. These ingredients, similar to THC (tetrahydrocannabinol) and CBD (Cannabidiol), are called cannabinoids. Some cannabinoids are also produced in laboratories to act like those within the plant.

The healing Cannaibia occurs in various forms, similar to oils, capsules, dried flower (utilized in a steamer), sprays and edible forms similar to jelly beans.

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Because regulatory changes in 2016 made medical hemp more available, the Australian regulatory authority issued Over 700,000 approvals. (But healing hemp approval does not reflect the actual number of patients treated. One patient could have many approvals, and never all approved products are necessarily prescribed or supplied).

About half of the approvals concerned chronic pain, which is just not attributable to cancer.

In Australia, chronic pain affects one in five Australians aged 45 and older, with a big impact on people’s lives.

So what are the present evidence in regards to the effectiveness of hemp hemp in chronic pain?

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What the evidence shows

AND 2021 Review of 32 randomized controlled tests The involvement of almost 5,200 people with chronic pain examined the consequences of marijuana or cannabinoids. The study showed a slight improvement in pain and physical functioning in comparison with placebo.

AND Previous review He stated that with the intention to achieve a 30% reduction in pain for one person, 24 people could be treated with medicinal marijuana.

Review 2021 also found slight sleep improvements and without coherent advantages for other measure of quality of life, in accordance with Previous reviews.

This does not mean that medicinal marijuana does not help anyone. However, he suggests that advantages are limited to fewer people.

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Many pain specialists questioned whether evidence of therapeutic marijuana is sufficient to support it within the event of pain.

. Faculty of Medicine PainKnowledgeable body dedicated to the training and education of specialist pain doctors recommend that medical hemp be limited to clinical trials.



What does the regulator say?

Tips on the Australian regulator, Administration of therapeutic goods (TGA), about healing marijuana within the event of chronic non -cancer pain, reflects these uncertainty.

TGA states exist limited evidence of medicinal marijuana ensure clinically significant pain in lots of pain. Therefore, potential advantages in comparison with the damage ought to be considered a patient-patient.

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TGA claims that medicinal marijuana should only be studied if other standard therapies are tried and didn’t provide sufficient pain relief.

When it involves the use of marijuana medical product, as a consequence of concerns in regards to the safety of inhaled marijuana, TGA believes that pharmaceutical class products (similar to Nabiximols or extracts containing THC and/or CBD) are safer.

Chronic pain affects about one in five Australians.
Dusan Pektovic/Shutterstock

What about people who say it helps?

This evidence could also be contrary to the experience of people who report relief in healing marijuana.

In clinical practice, people often react in a different way depending on their health states, beliefs and lots of other aspects. What works well for one person may not work for an additional.

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Research helps us understand what results are typical or expected for many people, but there’s a spread. Some people might imagine that healing marijuana improves pain, sleep or general well-being-especially if other treatments didn’t help.

What are the unintended effects and risk?

Like all medicine, medicinal marijuana potential unintended effects. They are frequently mild to moderate, including drowsiness or sedation, dizziness, impaired concentration, dry mouth, nausea and cognitive slowdown.

These unintended effects are sometimes greater for THC products with higher potency. They have gotten an increasing number of common on the Australian market. Thc products with high potency represent More than half of the approvals in 2025..

Generally in scientific research More people experience unintended effects than reporting the advantages of medical hemp.

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Women's hands drop CBD oil into a yellow cup.
After an extended use of marijuana, some people must take higher doses to get the identical effect.
NUVA RAMKI/Shutterstock

Medical Cannabis may affect other drugsEspecially people who cause drowsiness (similar to opioids), drugs for mental illness, counterpilers, blood thinning and immunosuppressive.

Even cannabidiol (CBD), which is just not considered intoxicating like THC, was related to serious drug interactions.

These risk is bigger when marijuana is prescribed by a physician who does not manage the patient’s chronic pain or does not contact other healthcare providers. Because healing marijuana is usually prescribed by separate teeth clinics, the fragmentated care may increase the danger of harmful interactions.

Another problem is to develop a disorder of the use of hemp (commonly understood as “addiction”). Found a study 2024 one in 4 people The use of medical hemp develops the use of cannabis. Symptoms of withdrawal – similar to irritability, sleep problems or hunger – can occur with frequent and intensive use.

For some people, tolerance may develop with prolonged use, which implies that it’s good to take higher doses to get the identical effect. This may increase the danger of developing cannabis use.

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How is it compared with other treatments?

As much Drugs for chronic painThe effectiveness of healing marijuana is low and is just not really useful because the only treatment.

There is nice evidence that in conditions similar to back pain, interventions, similar to exercises, cognitive behavioral therapy and self -management education, may help and may have less risk than many medications.

But there are challenges related to how available and reasonably priced these treatments are for a lot of Australians, Especially outside the important cities.

So where does it leave patients?

The growing use of healing marijuana within the event of chronic pain reflects each a heavy load on the community and gaps in access to effective care. While some patients report advantages, current evidence suggests that they can be small for many people and have to be weighted in relation to the danger.

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If you might be considering healing marijuana, it is essential to talk over with your strange healthcare provider, best knowing the total medical history, to provide help to determine about the very best approaches to provide help to treat pain.

This article was originally published on : theconversation.com
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Health and Wellness

5 best exercises to get rid of your mommy

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5 best exercises to get rid of your mommy

Royalty-Free Stock Photography by Rubberball.com

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Birth of a brand new life, although beautiful, might be one of the best victims that moms will resolve. In addition to changing the schedule and sometimes personal well -being, latest moms also experience body changes due to human cultivation for 9 months.

The convexity after pregnancy, “Mommy’s belly” or “Mommy Pooch”, is a reality for some moms, because some moms could also be difficult to “reflect” to their original body weight or smaller after childbirth. In addition, from a medical point of view, moms may experience a diastolic abdomen, which is frequently unrecognized and non -treated, but this condition is a vertical gap between the front abdominal muscles. Throughout the pregnancy, the muscles stretch to accommodate the growing fetus, making the connective tissue between the skinny and weakening abdominal muscles, causing abdominal abdominal. If DRA stays untreated, it may cause significant back pain and make it difficult to lift heavy objects, let alone exercise. In addition, mommy may be brought on by hormonal changes, separated by abdominal muscles and stretched soft tissue.

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Although latest moms are difficult to deal with themselves and their physical health, consistent exercise may be option to lose just a few postpartum kilos and defeat mommy. Unfortunately, just a few abdominal exercises, resembling options, crisps and boards, may cause an excessive amount of pressure on the connective tissue that you are trying to cure, which may worsen the separation of moms. That is why it will be important to deal with exercises, which specifically directed the muscles of the deep core and promote the final strength of the core. While everyone tells a novel story and desires exercises designed especially for them, there are five exercises that almost all women with Distasis of their routine will profit. If you’re a brand new mother who has a mission to remove her mongrel or bag or part of her support system, you must rewind below to check small and various exercises which are great for removing mommy.

Focus on ABS: Seated phrases AB:

  1. Start in a sitting position on the mat.
  2. Raise each legs and DNA, while supporting balance with each hands behind you.
  3. Keeping the upper body completely stationary, slowly twist the lower body on the appropriate, as possible, while maintaining control.
  4. Bring your legs back to the middle.
  5. Turn to the opposite side.
  6. To repeat.

Exercise the boards to engage your core:

  1. Start within the position of the forearm board.
  2. Keep your abdominal muscles and press your arms and shoulders once you raise your hips to the ceiling and chest towards the feet.
  3. Keep for 5-10 seconds.
  4. Return to the position of the forearm board and repeat.

Fire hydrant:

  1. Start again within the tablet position, arms under your arms, knees under the hips and a slight flexion of the elbows.
  2. Place the ball behind your right knee and bend your foot to engage the tendon and keep the ball in place.
  3. Then inhale and lift your knee behind your hips. Hold for a second, then exhale once you slowly release your knee back.
  4. Drink the burden into your right hand once you do it so that you simply don’t sink in your left hip and keep squeezing on this ball.
  5. Do this in total eight repetitions, then lift the knee and hold them by squeezing the ball for eight repetitions. Do this in total eight repetitions and repeat on the opposite side.

Brosting:

  1. Start lying on your back with bent legs, feet flat on the ground and shoulders on the edges.
  2. Then insert the tailbone and lift it from the ground by one vertebra directly until the torso forms a straight line from the shoulders to the knees.
  3. Stop up for a moment to squeeze your buttocks. Mocner Rover to come back to start with.
  4. To repeat

Tae Taps:

  1. Put your arms on the edges, the legs bent at 90 degrees, and the feet raised within the air in order that the shin is parallel to the ground.
  2. Depending on the hip joint, to leave the left foot towards the ground, not allowing the lower back to lose contact with the mat.
  3. Raise your leg back to the initial position, engaging a low stomach. This is one representative.
  4. Fill out two sets of 10 repetitions per page.

This article was originally published on : www.essence.com
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