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Can a medicine like Ozempic help treat addiction to alcohol, opioids or other substances?

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Semaglutide (marketed as Ozempic, Wegovy and Rybelsus) was initially developed for the treatment of diabetes. It works by stimulating insulin production to keep blood sugar levels under control.

This sort of drug is increasingly prescribed for weight reduction, though it was initially approved for a different purpose. Recently, there was growing interest in one other possible application: addiction treatment.

Anecdotal reports from patients taking semaglutide for weight reduction suggest that it reduces appetite and food cravings, but surprisingly, it may additionally reduce the will to drink alcohol, smoke cigarettes, or take other drugs.

But does the scientific evidence support this?



Animal studies show positive results

Semaglutide acts on glucagon-like peptide-1 receptors and is often called a “GLP-1 agonist”.

Animal studies in rodents and monkeys have yielded overwhelmingly positive results. Research suggests that GLP-1 agonists may reduce drug use and drug satisfaction, including alcohol, nicotine, cocaine and opioids.

Our team reviewed the evidence and located that over 30 different preclinical studies have been conducted. Most show positive leads to reducing drug and alcohol consumption or cravings. More than half of those studies focus specifically on alcohol use.

However, translating research findings from animal models to people living with addiction is difficult. While these results are promising, it remains to be too early to tell whether it should be secure and effective in people affected by alcohol use disorder, nicotine addiction, or other drug addiction.

What about human studies?

Results from human studies are mixed.

Just one large, randomized, controlled trial conducted to this point regarding alcohol. In a study of 127 people, there was no difference between exenatide (a GLP-1 agonist) and placebo (a dummy treatment) in reducing alcohol consumption or heavy drinking over 26 weeks.

In fact, all study participants reduced their drinking, each those taking energetic medications and people receiving placebo.

However, the authors conducted further analyzes to examine changes in drinking depending on body weight. They found that for individuals who had each alcohol use problems and obesity, alcohol consumption was reduced.

For individuals who began at a normal weight (BMI lower than 30), despite initially reducing their alcohol intake, they saw a sharp increase in heavy drinking after 4 weeks of treatment, with an overall increase within the variety of days of heavy drinking compared to those that took medication. placebo.

There were no differences between groups on other measures of alcohol consumption, corresponding to craving.

Some studies show a sharp increase in heavy drinking.
Demana/Shutterstock

In one other 12 weeks testresearchers found that dulaglutide, a GLP-1 agonist, didn’t help reduce smoking.

However, people receiving dulaglutide, a GLP-1 agonist they drank 29% less alcohol than those on placebo. More than 90% of individuals on this study were also obese.

Smaller studies have evaluated GLP-1 agonists short-term cocaine AND opioidswith mixed results.

Many other clinical trials are currently underway for GLP-1 agonists and alcohol-related and other addiction disorders.

We are awaiting results from larger studies, however it is difficult to interpret the conflicting results. These differences in response to treatment could also be due to individual differences that influence addiction, including physical and mental health problems.

Larger studies in broader human populations will tell us more about whether GLP-1 agonists will work in addiction, and in that case, in whom.

How might these drugs work for addiction?

The exact mode of motion of GLP-1 agonists just isn’t yet well understood, but as well as to reducing intake (food or medication), they may additionally reduce appetite.

Animal studies have shown that GLP-1 agonists reduce appetite cocaine AND opioids.

This may involve a key region of the brain’s reward system, the ventral striatum, with experimenters showing that once they directly administer GLP-1 agonists to this region, rats show reduced “hunger” oxycodone Or cocainepossibly by limiting drug-induced dopamine release.

Using human brain imaging, experimenters can induce cravings by showing images (signals) related to alcohol. Exenatide, a GLP-1 agonist decreased brain activity in response to an alcohol cue. The researchers observed reduced brain activity within the ventral striatum and septal areas of the brain, which connect to emotion-regulating areas corresponding to the amygdala.

In human studies, it’s unclear whether GLP-1 agonists act directly to reduce cravings for alcohol or other drugs. This must be directly assessed in future studies, taking into consideration any limitations of use.

Are these medications secure for addiction treatment?

Overall, GLP-1 agonists have been shown to be relatively secure in healthy adults and in individuals with diabetes or obesity. However, negative effects include nausea, digestive problems, and headaches.

And while some people don’t mind shedding weight as a side effect, others don’t. For example, if someone is already underweight, this medicine is probably not right for them.



Additionally, little or no research has been conducted on people affected by addictive disorders. However, some negative effects could also be more of a problem for addicts. Recent research shows, for instance, that: rare risk of pancreatitis related to GLP-1 agonists, and folks with alcohol use problems are already at greater risk of developing this disorder.

Other pharmacological treatments at the moment are available

While recent research on GLP-1 agonists for addiction treatment is an exciting development, far more research needs to be done to understand the risks and advantages of using these GLP-1 agonists for people living with addiction.

In the meantime, the variety of effective addiction treatments available remains to be too few. Just about 3% Australians addicted to alcohol, for instance, are prescribed such drugs naltrexone, acamprosate Or disulfiram. We need to make sure that current treatments can be found and that healthcare professionals understand how to prescribe them.

Continuous innovation in addiction treatment can be crucial. Our team is researching other personalized and effective treatments for alcohol addiction, while others are researching treatments for nicotine addiction and other drug addictions.


This article was originally published on : theconversation.com
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Health and Wellness

How light can change your mood and mental health

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It’s spring and you’ve got probably noticed a change within the sunrise and sunset times. But have you furthermore mght noticed a change in your mood?

We have known for a very long time that light affects our well-being. Many of us feel more positive when spring returns.

But for others, big changes in light, similar to originally of spring, can be difficult. For many, shiny light at night can be an issue. Here’s what’s happening.

An ancient rhythm of light and mood

In an earlier article in our series, we learned that light shining into the back of the attention sends “time signals”to the brain and the master clock of the circadian system. This clock coordinates our circadian rhythm.

“Clock genes” also regulate circadian rhythms. These genes control the timing of many other genes activate and off in a 24-hour light-dark cycle.

But how is all this related to our mood and mental health?

Circadian rhythms could also be disrupted. This can occur if there are problems with the event or functioning of the body clock, or if someone is usually exposed to shiny light at night.

When circadian rhythms are disrupted, it increases the chance of some mental disorders. They belong to them bipolar disorder AND atypical depression (a variety of depression where someone is amazingly sleepy and has problems with energy and metabolism).

Light for the brain

Light can also affect circuits within the brain that control mood, like animal studies show.

There is evidence that this happens in humans. A brain imaging study showed exposure to shiny light throughout the day while contained in the scanner modified the activity the world of ​​the brain chargeable for mood and alertness.

Another brain imaging study found the connection between every day exposure to sunlight and the best way the neurotransmitter (or chemical messenger) serotonin binds to receptors within the brain. In several cases, we observe changes in serotonin binding mental disordersincluding depression.

Our mood can improve in sunlight for a lot of reasons related to our genes, brain and hormones.
New Africa/Shutterstock

What happens when the seasons change?

Light can also affect mood and mental health because the seasons change. In autumn and winter, symptoms similar to low mood and fatigue may appear. However, these symptoms often disappear with the arrival of spring and summer. This is known as “seasonality” or, when severe, “seasonal affective disorder“.

What is less known is that for others, the transition to spring and summer (when there may be light) can also include changes in mood and mental health. Some people experience a rise in energy and willingness to be energetic. For some that is positive, for others it can be seriously destabilizing. This can be an example of seasonality.

Most people they usually are not very seasonal. But for many who are, seasonality matters genetic component. Relatives of individuals with seasonal affective disorder are also more prone to experience seasonality.

Seasonality can be more common in conditions similar to bipolar disorder. For many individuals affected by such conditions, the change in day length throughout the winter can trigger a depressive episode.

Counterintuitively, longer days in spring and summer can also destabilize individuals with bipolar disorder in “activated” is a condition during which energy and activity are in excess and symptoms are harder to regulate. Seasonality can due to this fact be serious.

Alexis Hutcheon, who experiences seasonality and helped write this text, told us:

(…) the change of season is like preparing for a battle – I never know what is going to occur, and I rarely emerge unscathed. I’ve experienced each hypomanic and depressive episodes brought on by the change of season, but whether I’m up or down, the one constant is that I can’t sleep. To cope, I attempt to persist with a strict routine, adjust my medications, maximize light exposure, and at all times concentrate to subtle mood changes. This is a time of increased awareness and the need to be one step ahead.

So what happens within the brain?

One explanation for what happens within the brain when mental health changes with the seasons involves the neurotransmitters serotonin and dopamine.

Serotonin helps regulate mood and is the goal many antidepressants. There is a few evidence of seasonal changes in serotonin levels, which could also be lower IN Winter.

Dopamine is a neurotransmitter involved in reward, motivation and movement, and for some it is usually a goal antidepressants. Dopamine levels may additionally fluctuate with seasons.

However, the neuroscience of seasonality is an emerging field that requires further research is required know what is going on within the brain.

How about shiny light at night?

We know that exposure to shiny light at night (for instance, when someone has been up all night) can disrupt someone’s circadian rhythm.

This variety of circadian rhythm disorder is related to a more frequent occurrence of symptoms including self-harm, depressive and anxiety symptoms and deterioration of well-being. This also comes with higher rates mental disorderssimilar to major depression, bipolar disorder, psychotic disorders and post-traumatic stress disorder (PTSD).

Why is that this? Bright light at night confuses and destabilizes the biological clock. It disrupts the rhythmic regulation of mood, cognition, appetite, and metabolism many Other mental processes.

But persons are very different from one another sensitivity to light. It continues to be a hypothesis that people who find themselves most sensitive to light could also be most prone to disruption of their biological clock brought on by shiny light at night, which consequently results in a greater risk of mental problems.

Man studying at the computer late at night
Bright light at night disrupts your body clock, putting you at greater risk of mental problems.
Ollyy/Shutterstock

Where to from here?

Learning about light will help people cope higher with their mental health problems.

By encouraging people to raised adapt their lives to the light-dark cycle (to stabilize their body clock), we can also help prevent conditions similar to: depression AND bipolar disorder appears first.

Healthy light habits – avoiding light at night and looking for light throughout the day – are good for everybody. But they can be especially helpful to humans endangered mental health problems. These include individuals who have a family history of mental health problems or who’ve them night owls (sleeping late and getting up late), that are more prone to biological clock disturbances.


This article was originally published on : theconversation.com
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Health and Wellness

Megan Thee Stallion reflects on disconnecting her mother from life support in a new documentary

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Megan Thee Stallion’s new documentary is now streaming on Prime Video; was a hot topic of conversation on the Internet. While the main target is on the rapper’s history with Tory Lanez, it also touches on one other vital topic; disconnecting her late mother, Holly Thomas, from life support. Thomas died in March 2019 of a brain tumor, leaving the rapper without living parents. The rapper also lost her father, Joseph Pete Jr., when she was in ninth grade.

“They had to put her down. She was just brain dead,” Megan said in the documentary. “So I used to be there each day. I spent the night in the hospital. I just prayed she would recover from it.

Unfortunately, Thomas, who was also the rapper’s first manager, couldn’t cope.

“When I realized she wasn’t coming back, I thought, ‘Shit, I can’t hold her like this.’ Because I know she wouldn’t want to stay like this,” Megan recalls through tears. “So I had to make the decision to pull the plug, and she just died the next day.”

The artist coped despite great grief and three weeks after Holly’s death she returned to the stage.

“You know that 2019 was a really difficult year for me. “I don’t want to cancel any of my shows and I don’t want to stop going because that’s not what my mom would want,” she said from the stage in a clip from the documentary. “She was my number one fan, despite all the butt-shaking and swearing.”

The HISS rapper opened up in regards to the impact of losing her mother on her mental health. This sadness was compounded by a series of events that occurred after the 29-year-old was shot by Tory Lanez. The shooting occurred in 2020, and Lanez was sentenced to 10 years in 2023.

“When my mom died, I think I really forgot who I was and lost a lot of self-confidence,” she said. “I was used to my mom telling me what to do, and when life started getting crazy, I didn’t have her.”

At the documentary’s premiere in Los Angeles, Megan thanked her mother, expressing her appreciation for the girl she has grown into.

“Without Holly Thomas, I wouldn’t be the woman I am today,” she told the audience. “So Mommy, I love you.”

This article was originally published on : www.essence.com
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Health and Wellness

New Zealand needs to rethink multi-bed hospital rooms

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How New Zealand laments its hospitals – where they’re positioned, how they must be staffed and the way they must be financed – the talk misses a key element: the necessity for single rooms in all public hospitals.

It is now normal for patients to stay in shared rooms with up to five other people. In some hospitals, this includes housing men and ladies in the identical room, despite serious injuries safety and ethical issues.

But it should not be like this. For many reasons, including infection control, privacy and price, latest hospitals and renovations must depend on single-occupancy rooms.

Our latest research brings together each the clinical and ethical arguments for adopting single rooms for all patients as probably the most basic standard of care.

Infection control

Many people might even see shared rooms as a value savings. However, certainly one of the important thing arguments for separate rooms in hospitals is the prices and damages related to infections and bacterial resistance.

Single rooms reduce the chance by eliminating exposure to common sources of infection akin to touched surfaces, unfiltered air, toilets and water systems.

They too reduce the necessity to move rooms in hospital, which increases the chance of transmitting infection between patients.

There is robust evidence that single rooms are affected reducing the variety of infections in intensive care units. AND further research also found that single accommodation reduced the chance of Covid-19 transmission in hospital.

In New Zealand, the priority is single rooms for patients known to be infectious. But the important thing word here is . This policy doesn’t take note of the proven fact that a big proportion of infectious diseases are unknown on the time of admission.

However, even when the infection is thought, our hospitals are unable to meet basic guidelines due to the dearth of single rooms. For example, only 30% of hospital rooms in Wellington and Hutt are designated for single use.

Without single occupancy as the usual in hospitals, infection control will remain in danger.

Hospital rooms in New Zealand can accommodate up to six beds and accommodate each female and male patients.
Sandra Mu/Getty Images

Delirium and dementia

Separate rooms are also required for older people. New Zealand’s population is aging; because of this, the variety of patients with delirium and dementia requiring hospitalization will increase.

Delirium affects roughly 25% of hospitalized patients and is related to an extended stay, more complications, and an increased risk of death.

Prevention and treatment of delirium requires a low-stimulus environment, undisturbed sleep, and light-weight and noise control that can’t be achieved in shared hospital rooms.

Tests showed a discount in delirium for single rooms.

The behavioral and psychological symptoms of dementia also pose significant challenges in hospital. Symptoms include hallucinations, delusions, sleep disturbances, depression, inappropriate sexual behavior and aggression.

They might be very disturbing for the patient and people around him and, like delirium, basic standard of care can’t be provided within the common room.

By 2050, the incidence of dementia will greater than double. Yet New Zealand’s hospitals are ill-equipped to deal with rising demand.

The right to safety, privacy and dignity

Shared spaces in hospitals clearly undermine clinical care, but additionally violate human and patient rights.

One of probably the most basic human rights is “personal security”. No one should share a room with patients who’re agitated, aggressive or sexually inappropriate due to delirium or dementia.

Unfortunately, patients often share with those that are unable to control their very own behavior. While threats to women as has been emphasized, no patient should feel threatened or frightened by one other patient’s behavior.

Dignity and privacy are also fundamental patient rights, and privacy is roofed by each provisions Health Information Privacy Code and Code of patient rights regarding health and disability.

Hospital patients often need assistance dressing, showering and toileting. Many admissions are related to vomiting, diarrhea or urinary incontinence. And the design counting on curtains for privacy makes it a farce.

Tests AND complaints clearly show patients that they don’t imagine their privacy is sufficiently protected in shared spaces.

Some may advocate for multi-bed rooms, arguing that some patients prefer company. However, patient surveys regarding privacy and confidentiality overwhelmingly favor single-occupancy rentals.

Cost consideration

Although the initial costs for constructing single rooms increase due to the larger hospital space, tests concluded that there was no compelling economic evidence in favor of shared rooms.

The potential savings in future pandemics – when it comes to mortality, patient transfer and disease transmission – mustn’t be underestimated. Better management of delirium and dementia may even reduce length of stay and costs.

Collectively, the case for single-occupancy hospital rooms on clinical, ethical and legal grounds is obvious.

New Zealand must follow international best practice and introduce single rooms as the first standard when constructing and refurbishing latest hospitals.

Failure to accomplish that would ignore the teachings learned from the Covid-19 pandemic, fail to take note of the needs of an aging population and would further render New Zealand’s Patient Rights Code a fairy tale.

This article was originally published on : theconversation.com
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