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I was a beta tester for the Nobel Prize-winning AI AlphaFold – it will revolutionize health research

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Deep learning machine AlphaFoldwhich was created by the Google AI research lab Deep Mindis already changing our understanding of the molecular biology underlying health and disease.

One half Nobel Prize 2024 in Chemistry went to David Baker from the University of Washington, USA, and the other half awarded jointly Demis Hassabis AND John M. Jumpereach from London-based Google DeepMind.

If you have not heard of AlphaFold, it could also be hard to understand how essential it is becoming to researchers. However, as a beta tester of the software, I had the opportunity to see firsthand how this technology could reveal the molecular structures of assorted proteins in a matter of minutes. It would take researchers months and even years to separate these structures in laboratory experiments.



This technology could pave the way for latest, revolutionary therapies and medicines. But first, it’s essential to grasp what AlphaFold does.

Proteins are created as a results of a series molecular “beads”created from the choice of the human body 20 different amino acids. These beads form a long chain that folds into mechanical shape that is crucial for the functioning of the protein.

Their sequence is set by DNA. And although DNA testing signifies that we know the order of the beads that make up most proteins, predicting how the chain will assemble into each “3D machine” has all the time been a challenge.

Nobel Prize winners David Baker, Demis Hassabis and John M. Jumper.
Illustrations: Niklas Elmehed © Nobel Prize Awareness Campaign, CC BY-NC-SA

These protein structures form the basis of all biology. Scientists study them in the same way that you just might take a clock apart to grasp how it works. Understand the parts and put the whole together: it’s the same with the human body.

Proteins are tiny, and there are huge numbers of them in each of them our 30 trillion cells. This meant that for a long time the only strategy to determine their shape was through laborious experimental methods – research that might take years.

Throughout my profession, like many other scientists, I have been engages in such activities. Every time we solve a protein structure, we put it into a global database called Protein Data Bankwhich everyone can use for free.

AlphaFold was trained on these structures, most of which were used X-ray crystallography. In this method, proteins are tested in hundreds of various chemical states, with changes in temperature, density and pH. Scientists use a microscope to find out the conditions under which each protein assembles into a specific formation. They are then exposed to X-rays to find out the spatial arrangement of all the atoms in the protein.

After being trained in these designs, AlphaFold can now just do that predict the structure of a protein at speeds that were previously not possible.

I began at the starting of my profession, in the late Nineties, developing protein structures using the magnetic properties of their nuclei. I did this using a technology called nuclear magnetic resonance (NMR), which uses a huge magnet just like an MRI scanner. This method began to fall out of favor resulting from some technical limitations, but that is the way it is now is experiencing a rebirth thanks AlphaFold.

NMR is one among the few techniques that may study molecules in motion, quite than holding them stationary in a crystal or on an electron microscope grid.

Woman holding a scientific sculpture.
Author Rivka Isaacson holds an atomically accurate 3D printed ribosome.
Rywka Isaacson, Provided by creator (no reuse)

An addictive experience

In March 2024, DeepMind researchers asked me to check the beta version of AlphaFold3, the latest incarnation of the software that was near release at the time.

I’ve never been a gamer, but I got a taste of the addictive experience because once I gained access, all I desired to do was spend hours trying out molecular combos. In addition to lightning-fast speed, this new edition introduced the ability to include larger and more diverse molecules, including DNA and metals, in addition to the ability to switch amino acids to mimic chemical signaling in cells.

Our laboratory at King’s College London used X-ray crystallography predict the structure formed by two bacterial proteins which can be loosely involved hospital superbugs once they interact. Previous incarnations of AlphaFold predicted individual components but could never solve the problem accurately – and yet the new edition solved the problem the first time.

Understanding the moving parts and dynamics of proteins is the next frontier now that we are able to predict the static shapes of proteins using AlphaFold. Proteins are available in a huge number of sizes and shapes. They may be rigid or flexible, or product of rigorously structured units connected by flexible loops.

Dynamics are essential for protein function. As one other Nobel Prize winner – said Richard Feynman: “Everything that living things do can be understood in terms of the oscillations and vibrations of atoms.”

Another great feature of magnetic resonance techniques is the ability to exactly measure the distances between atoms. So, after some rigorously designed experiments, AlphaFold’s results may be verified in the laboratory.

In other cases, the results are still inconclusive. This is a work in progress between experimental structural biologists like my team and computational scientists.

The recognition that comes with a Nobel Prize will only spur the pursuit of understanding the entire molecular machinery and hopefully change the landscape when it involves drugs, vaccines and human health.

This article was originally published on : theconversation.com
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Health and Wellness

Demeatria Boccella interrupts the AFRICANISM 2024 gala in Pittsburgh – Essence

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Courtesy of Demeatria Boccelli

When Demeatria Boccella enters a room, there may be a magnetic aura that draws your attention. She also embodies a quiet confidence with a touch of charm that makes you adjust your posture whenever you see her approaching, which is strictly what happens once we meet at Ice House Studios in Pittsburgh’s Lawrenceville neighborhood. Boccella, founder AFRICAN fashion The organization arrives wearing a full-length Comme Des Garçons trench coat, an oversized white shirt and black trousers by Maison Margiela. Her signature shaved head can be a key accessory. The multi-hyphenate is a walking embodiment of effortless elegance and style.

Boccella describes her fashion aesthetic as layered minimalism. This phrase perfectly describes the FashionAFRICANA studio, which is a handful once we enter. Only a 6-meter gold Afro pickaxe, a 2-meter Yoruba mask and a large number of striking portraits of Mario Epanya’s beauties scattered throughout the room give a touch of the royal wealth related to Demeatria’s idea. Guests can have the opportunity to experience these details as they walk through the doors of the gala, which can happen on November 21, during the second edition of the edition AFRICANISM Gala. There can be a world celebration of culture, heritage and creativity.

As founder and executive director of FashionAFRICANA, Demeatria has made it her mission to raise Black designers by making them accessible to Pittsburgh’s artistic landscape. She founded the organization 23 years ago. What began as a street fashion show in 2001 grew right into a series of exhibitions and in-person events that put the Pittsburgh fashion scene on the map. Some previous exhibitions include a presentation by Mario Epanya and Cedric Mizero. But as the visionary answerable for bringing the Paul Tazewell exhibition to Pittsburgh and presenting the world with the first Ruth E. Carter costume retrospective, Boccelli’s influence now extends far beyond the city limits, reaching across the ocean to the shores of Africa.

Demeatria Boccella interrupts the AFRICANISM 2024 gala in Pittsburgh
AFRICANISM Gala 2023. Photo source: Emmai Alaquiva.

At last yr’s inaugural gala, Cameroonian couture designer Imane Ayissi, costume designer Paul Tazewell and visual artist Charly Palmer took center stage. It is price noting that Tazewell and Palmer were Africana Icon recipients. Tazewell is generally known for his performances directed by George C. Wolfe and Lin-Manuel Miranda.

In the conversation, Boccella explains that FashionAFRICANA’s mission is to create a bridge between Black artists here in the United States and people on the continent. “Through our initiative, we not only create intercultural connections, but we create a platform for the presentation of artists, while providing opportunities that close [artist] equity gap,” she shared.

It’s the type of exposure and involvement that Boccella did not have access to but desperately needed as a young black girl growing up in Pittsburgh’s Glen Hazel neighborhood. She says she is a born creative person, but she also credits her mother for her appetite for fashion.

“I remember I was a little kid, maybe a four- or five-year-old kid. And my mother tied these scarves on her head,” Boccella tells ESSENCE. “It was like that in the Seventies [tie] scarves in every single place, around the chest, in every single place around the head. I remember when she tied those scarves and did those flowers on the side and did all those things, she looked stunning.

Demeatria dreamed of sooner or later becoming a model and dealing in the fashion world. But those dreams were quickly dashed when she didn’t see women with strong African features and dark skin like her on TV or in the magazines she devoured as a toddler. This frustration, combined with the teasing she experienced as a darker-skinned child, destroyed her perception of beauty and self-esteem. “At one point my depression was so bad that I cut up every photo of myself,” she recalled.

The founder says because of this she is so enthusiastic about creating secure, creative spaces for young people, in addition to supporting FashionAFRICANA. She is motivated by the incontrovertible fact that she doesn’t want the younger generation to feel different, as she felt when she was younger. “When you walk into these rooms, you will see a positive reflection of yourself. “I want them to be proud of who they are,” she said. Here she notes that part of her journey towards self-love and acceptance was learning about her African heritage through art and fashion. “I feel like it kind of saved my life, so [this] she was my driving force.”

During the second AFRICANISM gala, guests will feel as in the event that they have been transported to a black utopia, said Darnell L. McLaurin, co-founder and inventive director of FashionAFRICANA. He added that it’ll be an area immersed in the celebration of the African diaspora. There can be performances by rappers Mayce Tomlin and Che “Rhymefest” Smith and a dinner honoring Tony Award-winning artist Kenny Leon. In addition, the fashion festival will present the works of visual artist, designer and former journalist Dion Dewand Marcia Lafalaise from Côte d’Ivoire. Guests can be treated to a night stuffed with splendor.

Demeatria Boccella interrupts the AFRICANISM 2024 gala in Pittsburgh
The model is wearing Dion Dewand Marcia Lafalaise creations. Photo source: Joanna Totolici.

The theme of this yr’s gala is titled or . In Boccelli’s words, the universe selected the subject. He explains that since that is the first time they can be inviting their followers to their studio, it seemed appropriate. When deciding on the designer and artist-in-residence, Boccella noticed that Lafalaise introduced the story of her latest collection with the message “Welcome Home.” “[I] I knew it wasn’t a coincidence,” she added.

Whether by probability or fate, it was Lafalaise’s mastery of cowrie shells and Afrofuturism sewn into each of her works. The ancestral bonds woven throughout each bit drew the team to her aesthetic designs.

The visual artist shared that her latest work, “Abondance,” was inspired by the powerful symbolism that our ancestors nurtured and the deep-rooted connections that lots of us have with our heritage. “It combines a touch of modern aesthetics with the essence of our culture. As creators, we reached beyond the physical to create something extraordinary, guided by the symbolism of the cowrie shell,” explains Lafailase.

Demeatria Boccella interrupts the AFRICANISM 2024 gala in Pittsburgh
Creations by Dion Dewand Marcia Lafalaise. Photo credit: Dion Dewand Marcia Lafailaise

Here, the artist explained that the shell is a representation of creation, source, divine feminine and strength. “My work honors the creativity and collaboration of artisans from across Africa, from fabrics from Zimbabwe and Senegal to the crafts of Madagascar, all centered in its place of origin, Côte d’Ivoire.”

Introduced into the mainstream by Lupita Nyong’o, Beyoncé and Agojie of , Lafalaise high fashion has gained wide recognition. And the pioneering designer guarantees that she is going to present something fresh in her gala debut. He describes it as “a spiritual journey rooted in heritage.”

Lafailaise assures that the upcoming celebrations can be greater than a conventional fashion show. Instead, it’ll be an inventive performance “that celebrates the act of creation, the divinity and artistry of Africa,” he declares. Through the collection, he wants to interrupt boundaries and open latest dialogues. He hopes that every one this can contribute to a deeper understanding and admiration between continents. Lafailaise says this can be a moment to keep in mind that we’re all inextricably connected. “I hope this experience wakes up [a] a way of unity in all,” he adds.

The upcoming festival can be greater than just a night of fun. All proceeds from the gala may also support the goals of FashionAFRICANA, which provides arts and cultural education to middle and highschool students. Mary McKinney Flaherty, co-chair of this yr’s event, said in an email that the evening can be a chance to showcase the band’s commitment to a younger generation of creators. He also notes that they do that yr-round through programs like The Art of Design and Storytelling and the August Wilson New Voices Competition through the Bill Nunn Theater Outreach Project. Each of them helps nurture the next generation of artists and leaders while empowering young Black Pittsburghers to search out and develop their voices.

Demeatria Boccella interrupts the AFRICANISM 2024 gala in Pittsburgh
The team behind this yr’s AFRICANISM gala: Darnell L. McLaurin, Kiya Tomlin, Demeatria Boccella and Mary McKinney Flaherty. Photo credit: Rachel Rowland

One of the principal programs necessary to Boccelli is the Next Narrative Monologue Competition, founded in 2007 by Todd Kreidler and Kenny Leon. Along with Atlanta and New York, Pittsburgh was one among the first cities to participate in the program because of Boccelli’s friend and mentor, Bill Nunny. When Nunn needed to withdraw as a result of a cancer diagnosis, Demeatria became managing director of the Pittsburgh branch in 2009. Since then, he has mentored monologue winners from the region to New York to perform on Broadway.

“The opportunity to witness the transformation of our young people through the words of August Wilson is life-changing,” he enthuses. “That’s why there are people like Denzel Washington, Samuel L. Jackson and Viola Davis who are so committed [Wilson’s] Work. When we host a monologue competition in New York, they and other legends volunteer to give master classes to our youth.” Boccella mentions that celebrity volunteers made a difference – noting that this chapter provides participants with exposure, knowledge and artistry from legendary artists. “Seeing this unfold is confirmation that I’m doing what I’m supposed to be doing.”

When asked what she expects from the guests of the AFRICANISM gala, Boccella recalls a quote from August Wilson. “There is an Africa in each of us that we need to connect with to understand our relationship with this society,” he says proudly.

She explains that she really likes this quote because when she first began FashionAFRICANA along with her team, she wanted everyone to feel included. This is the line from the organization to next week’s scandal. According to Boccelli, it was all about supporting the community.

Boccella hopes that participants can have the opportunity to see the fantastic thing about the city in addition to the African diaspora. “Art is an important tool for bringing people and communities together and for mutual learning. The only way we are able to change the beauty standards in this society is to ask them in.”

This article was originally published on : www.essence.com
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Health and Wellness

Prostate cancer organization launches website for personalized treatment

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The Prostate Health Education Network (PHEN), whose mission is to eliminate racial disparities related to prostate cancer amongst African Americans, announced the launch of this system PHENPM.coma brand new online portal dedicated to precision medicine care for prostate cancer patients. Precision medicine is medical care aimed toward improving the treatment of specific groups of patients, especially through molecular and/or genetic profiling. This progressive website includes information on personalized prostate cancer treatment, patient genomic testing, targeted therapy for the disease, precision medicine clinical trials and molecular diagnostics.

“Our goal in creating this portal is to help prostate cancer patients learn about the many benefits of precision medicine therapies, such as expanded treatment options, improved targeted therapies, better cancer detection tools, immunotherapies with fewer side effects and improved quality of life,” he said Dr. Keith Crawford, director of patient education and clinical research at PHEN.

Patients also can study genomic testing for prostate cancer, which involves determining genetic history and predisposition to cellular mutations. Additionally, the Precision Medicine Portal offers insight into patients’ lives through stories of how precision medicine and personalized prostate cancer treatments saved their lives.

One of PHEN’s goals is to diversify clinical trials by including more African Americans. PHENPM.com also deals with personalized treatment through participation in clinical trials. Clinical trials tailored to individual patient needs can revolutionize prostate cancer treatment, save lives and improve the standard of life for every patient.

“There’s no way around it. Black men have a significantly higher risk of prostate cancer and mortality. That’s why genetic testing is crucial,” Crawford said. One in six black men are diagnosed with prostate cancer, almost 80% more often than white men. To achieve its mission of eliminating this disparity in prostate cancer, PHEN provides free online resources for African American prostate cancer patients, survivors and high-risk individuals. Together with PHENPM.comyou can learn about prostate treatment by visiting PHENPath.com.

For information regarding clinical trials, PHENTrials.com invites patients to take part in personalized prostate cancer research. Information about early detection screening could be found on the website PHENPSA.com.


This article was originally published on : www.blackenterprise.com
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Health and Wellness

6 things to do if your baby’s weight is outside the ideal range – and 1 thing to avoid

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One of the most significant challenges we face as parents is ensuring that our kids develop at a healthy pace.

To combat this, we take them to regular check-ups with our GP or nurse, where vital measurements, including weight and height, are recorded and compared to the ‘ideal’ range.

But how accurate are these measurements? What to do if your baby’s weight is outside the ideal range?

How is kid’s weight measured?

It is vital to help our kids maintain a healthy weight. Around 80% of kids People who’re obese during adolescence will struggle with their weight throughout their lives.

GPs and nurses frequently measure your baby’s height and weight and use growth charts to visualize your baby’s growth over time. They often use two charts covering:

  1. birth to two years of age, which it assumes World Health Organization standards. They were developed based on studies in six countries that measured the growth of healthy breastfed infants

  2. from two to 18 years old, which takes the charts from US Center for Disease Control for kids and adolescents, body weight, height and body mass index (BMI).

These charts use percentile lines to plot a toddler’s measurements in the type of a growth curve, which is then compared to the expected – or ideal – range of weight and height taken from children of the same age and sex.

A baby’s development is considered healthy if his or her measurements consistently follow percentile lines. Poor growth is characterised by a bent for a toddler’s weight or height to decline at each percentile.

For children under two years of age, a body weight above the eighty fifth percentile is considered extent of obeseand weight-for-age above the 97th percentile is included in the obesity range.

In children over two years of age, a BMI above the eighty fifth percentile is taken into consideration overweight and a BMI above the ninety fifth percentile is classified as obesity.

But height and BMI charts are usually not perfect

Growth charts provide a straightforward yet effective indication of our child’s growth and development. They may help healthcare employees detect potential health problems early in order that they might be examined by a specialist.

However, growth charts could cause parents numerous anxiety and stress because they do not understand that every child grows and develops at a unique rate.

That’s why it is so vital to assess trends and changes in body weight over time and not react to measurements that will show outliers.

1 thing to avoid if your child is above the ideal range

NO limit your child’s food intake or restrict your eating regimen if they fall outside the ideal range. Although this may increasingly help them lose weight initially, it’s going to be harmful later.

Putting a eating regimen on a young child affects their ability to metabolize food and their innate ability to regulate their food intake as they grow and develop. This may have an effect their relationship with food and over time they speed up the weight problem.

Holding on to your child’s weight may also lead to anxiety, low self-esteem, and eating disorders body image problems.

6 things you may do

If your child’s weight is outside the ideal range, proceed to monitor his or her growth over time and deal with allowing her or him to “grow” to a healthy weight. You can do this by:

1. Focus on health, not weight

Each of us has a predetermined weight: a set value that our body protects. It is programmed in the early years of life – especially in the first 2,000 days of life – from conception to age five.

Our genes play a task in programming our weight setpoint. Just as DNA determines whether we’re shorter or taller than others, this is what it is be born with a bent to be slimmer or larger. But our genetic makeup is only a predisposition, not an inevitable fate.

Developing healthy habits and a positive approach to eating, exercise and body image in the family home will help your child achieve an optimal body weight throughout their life.

This includes:

  • teaching your child about nutrition by discussing the importance of the foods we eat and why certain foods are only eaten sometimes

  • finding time for each day activity that focuses on having fun with movement moderately than exercising to lose weight or change your appearance

  • being attentive to how we discuss our bodies and avoiding negative comments about weight and appearance.

2. Reach for nature first

Provide your child with loads of “nature delicacies” – for instance, fresh fruit and vegetables, honey, nuts and seeds. In their natural state, these foods trigger the same pleasure response in the brain as highly processed junk and fast food, and additionally they provide the nutrition your body needs.

3. Eating a full rainbow

Offer your child a large range of foods with different colours and textures. Cook your family’s favorite dishes in alternative ways, e.g. spaghetti bolognese with lentils as a substitute to spaghetti bolognese with beef.

Being a more adventurous eater helps kid’s development palate and provides them with the nutrients their bodies need for healthy growth and development.

4. Making meals relaxing and enjoyable

Involve the whole family in meals. Improve your baby’s innate characteristics appetite regulation slowing down and eating together at the table. Slowing down your eating means there is enough time for appetite hormones to be sent to your brain and signal that you’ve got had enough.

Meals which are calm and enjoyable also help create positive associations with healthy eating and help overcome dietary problems.

5. I play day-after-day

Consider (*1*)national business guidelines to understand your child’s movement needs at every stage of its development. For most age groups, this is about 60 minutes of physical activity or vigorous play, which might be divided into several smaller series.

Schedule regular time for activities that involve movement and play, resembling lively games, sports, and family walks and bike rides.

6. Back to screen time rules

Ensure your child has a healthy exposure to screens and a very good night’s sleep by developing healthy technology habits and implementing easy rules, resembling setting screen-free zones at mealtimes and in the bedroom.

Create positive entertainment alternatives that bring the family together.

This article was originally published on : theconversation.com
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